Michael J. Friedlander

About

Michael J. Friedlander, PhD, is the Vice President for Health Sciences and Technology at Virginia Tech. He is a neuroscientist who also serves as the executive director of the Fralin Biomedical Research Institute, senior dean for research at the Virginia Tech Carilion School of Medicine, and a professor of biological sciences and biomedical engineering and sciences at Virginia Tech. Friedlander joined Virginia Tech in 2010 after serving five years at Baylor College of Medicine in Houston, Texas, where he was the Robertson Professor of Neuroscience, chairman of the Department of Neuroscience, and director of neuroscience initiatives. Prior to that, he spent 25 years at the University of Alabama at Birmingham School of Medicine, where he held multiple roles including professor and founding chair of the Department of Neurobiology, founding director of the Neurobiology Research Center, and director of several research centers focused on intellectual disabilities and aging. His research programs on brain development and response to experience have been continuously supported by the National Institutes of Health for 30 years.

Research topics

• Computer Science
• Medicine
• Nursing
• Pathology
• Internal medicine
• Business
• Family medicine
• Environmental health
• Virology
• Demography

Selected publications

• First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial

  Journal of Clinical Oncology · 2024-11-26 · 53 citations

  articleOpen access

  PURPOSE Lenvatinib plus pembrolizumab (len + pembro) significantly improved progression-free survival (PFS) and overall survival (OS) versus chemotherapy in previously treated advanced or recurrent endometrial cancer (aEC) in the phase III Study 309/KEYNOTE-775. We report results from the phase III, randomized, open-label European Network of Gynaecological Oncological Trial-en9/LEAP-001 study (ClinicalTrials.gov identifier: NCT03884101 ) that evaluated len + pembro versus chemotherapy in first-l…

  PublisherDOI

• Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States

  Emerging infectious diseases · 2022 · 8 citations

  In April 2021, a COVID-19 outbreak occurred at a correctional facility in rural Virginia, USA. Eighty-four infections were identified among 854 incarcerated persons by facilitywide testing with reverse transcription quantitative PCR (qRT-PCR). We used whole-genome sequencing to link all infections to 2 employees infected with the B.1.1.7α (UK) variant. The relative risk comparing unvaccinated to fully vaccinated persons (mRNA-1273 [Moderna, https://www.modernatx.com]) was 7.8 (95% CI 4.8-12.7),…

  PublisherOA PDFDOI

• A comparative analysis exposes an amplification delay distinctive to SARS-CoV-2 Omicron variants of clinical and public health relevance

  Emerging Microbes & Infections · 2022-12-02 · 5 citations

  articleOpen access

  Mutations in the SARS-CoV-2 genome may negatively impact a diagnostic test, have no effect, or turn into an opportunity for rapid molecular screening of variants. Using an in-house Emergency Use Authorized RT-qPCR-based COVID-19 diagnostic assay, we combined sequence surveillance of viral variants and computed PCR efficiencies for mismatched templates. We found no significant mismatches for the N, E, and S set of assay primers until the Omicron variant emerged in late November 2021. We found a s…

  PublisherOA PDFDOI

• Synaptic Plasticity in the Injured Brain Depends on the Temporal Pattern of Stimulation

  Journal of Neurotrauma · 2024-05-31 · 3 citations

  articleOpen accessSenior authorCorresponding

  Neurostimulation protocols are increasingly used as therapeutic interventions, including for brain injury. In addition to the direct activation of neurons, these stimulation protocols are also likely to have downstream effects on those neurons' synaptic outputs. It is well known that alterations in the strength of synaptic connections (long-term potentiation, LTP; long-term depression, LTD) are sensitive to the frequency of stimulation used for induction; however, little is known about the contr…

  PublisherDOI

• Antarctic Teleosts With and Without Haemoglobin Behaviourally Mitigate Deleterious Effects of Acute Environmental Warming

  bioRxiv (Cold Spring Harbor Laboratory) · 2021-04-28 · 1 citations

  preprintOpen accessSenior authorCorresponding

  Recent studies forecast that many ectothermic animals, especially aquatic stenotherms, may not be able to thrive or even survive predicted climate change. These projections, however, generally do not call much attention to the role of behaviour, an essential thermoregulatory mechanism of many ectotherms. Here we characterize species-specific locomotor and respiratory responses to acute ambient warming in two highly stenothermic Antarctic Notothenioid fishes, one of which ( Chaenocephalus aceratu…

  PublisherOA PDFDOI

Recent grants

• NIH Grant P01HD038760

  NIH · $6.7M · 2005

• NIH Grant P50HD032901

  NIH · $5.3M · 2000

• NIH Grant R01EY012782

  NIH · $2.8M · 2012

Frequent coauthors

• Audra Van Wart

  20 shared

• Richard M. Schwartzstein

  Beth Israel Deaconess Medical Center

  20 shared

• Carla V. Finkielstein

  Biomedical Research Institute

  17 shared

• Carol A. Aschenbrener

  16 shared

• Avi Rosenstrauch

  Achva Academic College

  15 shared

• Alessandro Ceci

  Biomedical Research Institute

  15 shared

• Iskander I. Ismailov

  Biomedical Research Institute

  13 shared

• D Kalikulov

  Biomedical Research Institute

  13 shared

Labs

• LeadershipPI

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