Michael Engel
· Professor of Pediatric Medicine, Pediatric Hematology and Oncology, Pediatric CancerUniversity of Virginia · Biochemistry and Molecular Genetics
Active 1952–2024
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About
Michael Engel is a Professor of Pediatrics at the University of Virginia School of Medicine. His educational background includes a B.S. in Biology and a B.S. in Biochemistry from Purdue University, followed by an M.D. in Cell and Molecular Biology and a Ph.D. in Cell and Molecular Biology from Vanderbilt University. His research interests focus on Pediatric Medicine, specifically Pediatric Hematology and Oncology, and Pediatric Cancer Research. His work involves investigating the biological mechanisms underlying pediatric cancers, contributing to the understanding and potential treatment of these diseases.
Research topics
- Oncology
- Medicine
- Internal medicine
- Pediatrics
Selected publications
JAMA Oncology · 2021 · 16 citations
IMPORTANCE: Alterations in the IKZF1 gene drive B-cell acute lymphoblastic leukemia (B-ALL) but are not routinely used to stratify patients by risk because of inconsistent associations with outcomes. We describe a novel deletion in 22q11.22 that was consistently associated with very poor outcomes in patients with B-ALL with IKZF1 alterations. OBJECTIVE: To determine whether focal deletions within the λ variable chain region in chromosome 22q11.22 were associated with patients with B-ALL with IKZ…
Cancer Research · 2024-03-22
articleSenior authorAbstract Acute Myeloid Leukemia (AML) represents a diverse category of blood cancers marked by the clonal proliferation of atypical myeloid precursor cells within the bone marrow. Lysine Specific Demethylase 1 (LSD1), an epigenetic regulator, exhibits elevated expression in AML. Consequently, inhibiting LSD1 has emerged as a promising therapeutic approach for addressing blood and bone marrow cancers. While initial emphasis centered on LSD1's enzymatic inhibition, compelling evidence highlights i…
2023-04-03
preprintOpen accessSenior authorSupplementary Data from GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
2023-04-03
preprintOpen accessSenior authorSupplementary Figure from GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
2023-04-03
preprintOpen accessSenior authorSupplementary Figure from GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
Recent grants
NIH · $172k · 2010
Targeting the GFI1-LSD1 Axis in T-Cell Acute Lymphoblastic Leukemia
NIH · $1.9M · 2017–2024
Regulation of MTG16 and Notch signaling in hematopoiesis
NIH · $728k · 2010–2016
Frequent coauthors
- 938 shared
Petra Moroni-Zentgraf
Boehringer Ingelheim (Germany)
- 913 shared
Ronald Dahl
- 907 shared
Donald P. Tashkin
University of California, Los Angeles
- 904 shared
Pierluigi Paggiaro
University of Pisa
- 901 shared
Carlos Melero Moreno
- 901 shared
Irina Bobolea
Hospital Clínic de Barcelona
- 900 shared
Mayte Villalba
Universidad Complutense de Madrid
- 900 shared
Natalia Blanca-L Opez
Hallym University
Labs
Biochemistry and Molecular GeneticsPI
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