Michael Chang

About

Michael Chang is an Associate Clinical Professor of Medicine at UC San Diego. His research focuses on esophageal anatomy and physiology, particularly across different phenotypes of disorders of esophagogastric junction outflow. His work includes studying diagnostic methods to measure spastic segments and guide tailored myotomy length in type 3 achalasia, as well as comparing various endoscopic techniques for gastrointestinal procedures. Chang has contributed to the understanding and management of gastrointestinal conditions through his publications and clinical expertise. His research also encompasses endoscopic management of gastrointestinal bleeding, treatment of biliary and esophageal conditions, and the development of innovative endoscopic techniques.

Research topics

• Biology
• Virology
• Bioinformatics
• Artificial Intelligence
• Computer Science
• Evolutionary biology
• Internal medicine
• Cartography
• Medicine
• Computational biology

Selected publications

• Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

  Nature · 2020 · 855 citations

  and the cysteine protease inhibitors MDL-28170, Z LVG CHN2, VBY-825 and ONO 5334. Notably, MDL-28170, ONO 5334 and apilimod were found to antagonize viral replication in human pneumocyte-like cells derived from induced pluripotent stem cells, and apilimod also demonstrated antiviral efficacy in a primary human lung explant model. Since most of the molecules identified in this study have already advanced into the clinic, their known pharmacological and human safety profiles will enable accelerate…

  DOI

• Gemini: A Family of Highly Capable Multimodal Models

  arXiv (Cornell University) · 2023 · 803 citations

  This report introduces a new family of multimodal models, Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from complex reasoning tasks to on-device memory-constrained use-cases. Evaluation on a broad range of benchmarks shows that our most-capable Gemini Ultra model advances the state of the art in 30 of 32 of these benchmarks - notably being the first mode…

  DOI

• Functional landscape of SARS-CoV-2 cellular restriction

  Molecular Cell · 2021 · 227 citations

  DOI

• Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome

  Cell Reports · 2022 · 104 citations

  Compositional oscillations of the gut microbiome are essential for normal peripheral circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time-restricted feeding (TRF) maintains circadian synchrony and protects against DIO, its impact on the dynamics of the cecal gut microbiome is modest. Thus, other regions of the gut, particularly the ileum, the nexus for incretin and bile acid signaling, may play an important role in entraining peripheral circadian rhythms. W…

  PublisherOA PDFDOI

• Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs

  Nature Microbiology · 2020 · 87 citations

  DOI

Frequent coauthors

• Christopher Benner

  University of California, San Diego

  38 shared

• Lars Pache

  Discovery Institute

  29 shared

• Adolfo Garcı́a-Sastre

  Icahn School of Medicine at Mount Sinai

  25 shared

• Sumit K. Chanda

  Scripps Research Institute

  21 shared

• Laura Martin‐Sancho

  Imperial College London

  16 shared

• Courtney Nguyen

  The University of Texas Health Science Center at Houston

  15 shared

• Paul D. De Jesus

  Scripps Research Institute

  13 shared

• Sascha H. Duttke

  Washington State University

  12 shared

Labs

• Michael Chang | UCSD ProfilesPI

Education

• Ph.D., Molecular and Computational Biology

  University of California, San Diego

  2000

• M.S., Molecular and Computational Biology

  University of California, San Diego

  1997

• B.S., Biology

  University of California, San Diego

  1995

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