Matthew S Kayser

About

Matthew S. Kayser, MD, PhD, is the Karl E. Rickels Associate Professor of Psychiatry at the University of Pennsylvania School of Medicine. He is an attending psychiatrist in the Department of Psychiatry and a member of the Chronobiology and Sleep Institute. Dr. Kayser specializes in issues related to sleep and mental health, with a focus on understanding how neural circuits give rise to complex behaviors and how dysfunctions in neural processes can lead to mental illness. His research primarily investigates the role of sleep in brain development and function, exploring how sleep contributes to the formation of neural circuits and its impact on psychiatric disorders. Utilizing the genetic model organism Drosophila melanogaster, his lab employs techniques such as genetics, behavioral assays, molecular biology, and imaging to study sleep, synapse formation, and behavior. His work aims to connect sleep abnormalities to the pathogenesis and treatment of neuropsychiatric diseases, with particular interest in how sleep influences brain development and behavior across the lifespan.

Research topics

• Neuroscience
• Biology
• Medicine
• Psychology
• Psychiatry

Selected publications

• The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects

  Science Advances · 2021-06-04 · 43 citations

  articleOpen access

  ortholog. We show that Kismet is required in glia for early developmental and adult sleep architecture. This role localizes to subperineurial glia constituting the blood-brain barrier. We demonstrate that Kismet-related sleep disturbances are caused by high serotonin during development, paralleling a well-established but genetically unsolved autism endophenotype. Despite their developmental origin, Kismet's sleep architecture defects can be reversed in adulthood by a behavioral regime resembling…

  PublisherOA PDFDOI

• Randomized Noninferiority Trial of Telehealth Delivery of Cognitive Behavioral Treatment of Insomnia Compared to In-Person Care

  The Journal of Clinical Psychiatry · 2021-08-23 · 39 citations

  articleSenior author

  Objective: Insomnia is prevalent and is associated with a range of negative sequelae. Cognitive behavioral treatment for insomnia (CBT-I) is the recommended intervention, but availability is limited. Telehealth provides increased access, but its efficacy is not certain. The objective of this study was to compare the efficacy of CBT-I delivered by telehealth to in-person treatment and to a waitlist control. Methods: Individuals with DSM-5 insomnia disorder (n = 60) were randomized to telehealth C…

  PublisherDOI

• Pathogenic variants in <i>SMARCA5</i> , a chromatin remodeler, cause a range of syndromic neurodevelopmental features

  Science Advances · 2021-05-12 · 32 citations

  articleOpen access

  Exome sequencing and Drosophila modeling revealed variants in SMARCA5 as a novel cause of a neurodevelopmental disorder.

  PublisherOA PDFDOI

• Developmental emergence of sleep rhythms enables long-term memory in <i>Drosophila</i>

  Science Advances · 2023-09-08 · 21 citations

  articleOpen accessSenior authorCorresponding

  In adulthood, sleep-wake rhythms are one of the most prominent behaviors under circadian control. However, during early life, sleep is spread across the 24-hour day. The mechanism through which sleep rhythms emerge, and consequent advantage conferred to a juvenile animal, is unknown. In the second-instar Drosophila larvae (L2), like in human infants, sleep is not under circadian control. We identify the precise developmental time point when the clock begins to regulate sleep in Drosophila , lead…

  PublisherDOI

• Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila

  Current Biology · 2022-08-18 · 17 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

Recent grants

• Molecular and genetic analysis of the juvenile sleep state

  NIH · $1.2M · 2021–2025

• Molecular and genetic analysis of sleep ontogeny

  NIH · $405k · 2020–2021

• Building brains in our sleep: A Drosophila larval platform for examining sleep and neurogenesis

  NIH · $2.4M · 2018–2023

Frequent coauthors

• Milán Szuperák

  University of Pennsylvania

  17 shared

• Josep Dalmau

  Hospital Clínic de Barcelona

  12 shared

• Tiong Yang Tan

  Royal Children's Hospital

  12 shared

• Naihua N. Gong

  University of Pennsylvania

  11 shared

• Matthew A. Deardorff

  California University of Pennsylvania

  10 shared

• David M. Raizen

  University of Pennsylvania

  10 shared

• Amy R. Poe

  University of Pennsylvania

  10 shared

• Emilia H. Moscato

  University of Pennsylvania

  9 shared

Labs

• Kayser LabPI

Education

• MD, PhD, Neuroscience

  University of Pennsylvania Perelman School of Medicine

  2009

• ScB, Neuroscience

  Brown University

  2000

Similar researchers at University of Pennsylvania

• John Q. Trojanowskih-296
• Craig B. Thompsonh-277
• Daniel J Raderh-236