Mary Playdon

Role of Diet in Colorectal Cancer Incidence

JAMA Network Open · 2021 · 256 citations

Importance: Several meta-analyses have summarized evidence for the association between dietary factors and the incidence of colorectal cancer (CRC). However, to date, there has been little synthesis of the strength, precision, and quality of this evidence in aggregate. Objective: To grade the evidence from published meta-analyses of prospective observational studies that assessed the association of dietary patterns, specific foods, food groups, beverages (including alcohol), macronutrients, and…

Metabolic dysfunction and obesity‐related cancer: Beyond obesity and metabolic syndrome

Obesity · 2022 · 157 citations

OBJECTIVES: The metabolic dysfunction driven by obesity, including hyperglycemia and dyslipidemia, increases risk for developing at least 13 cancer types. The concept of "metabolic dysfunction" is often defined by meeting various combinations of criteria for metabolic syndrome. However, the lack of a unified definition of metabolic dysfunction makes it difficult to compare findings across studies. This review summarizes 129 studies that evaluated variable definitions of metabolic dysfunction in…

Evaluating the Evolving Real‐World Adverse Events of <scp>GLP</scp> ‐ <scp>1RAs</scp> Using <scp>FDA</scp> Adverse Event Reporting System ( <scp>FAERS</scp> )

Obesity · 2026-03-09 · 2 citations

OBJECTIVE: This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon-like peptide-1 receptor agonists (GLP-1RAs) using the US FDA Adverse Event Reporting System (FAERS). Emphasis was placed on emerging safety concerns in context-specific use. METHODS: A retrospective analysis of FAERS reports between 2012 and 2025 was conducted. Five commonly prescribed FDA-approved GLP-1RAs were included. Disproportionality analyses were applied to detect AE signals. Subgr…

Abstract 3628: Obesity, metabolic dysfunction, and cancer risk: Uncovering the metabolic landscape

Cancer Research · 2026-04-03

Abstract As smoking rates decline, obesity has emerged as the leading modifiable risk factor for cancer in the United States. With obesity rates rising, especially in younger populations, its association with increased cancer risk is becoming more evident. There is an urgent need to understand the mechanisms underlying the relationship between obesity related metabolic dysregulation and cancer risk. This session highlights transdisciplinary research from the NCI-sponsored Metabolic Dysregulation…

Multi-metabolite scores of alignment with the 2018 World Cancer Research Fund (WCRF)/ American Institute for Cancer Research (AICR) Cancer Prevention Recommendations in the Interactive Diet and Activity Tracking in AARP (IDATA) Study

Journal of Nutrition · 2026-05-01