Mark Van Dyke

About

Mark Van Dyke is an Associate Dean of Research in the College of Engineering and a tenured Professor of Biomedical Engineering at the University of Arizona. His research primarily focuses on biomaterials, medical devices, prosthetics, regenerative medicine, tissue engineering, and entrepreneurial ecosystems. Throughout his career, Van Dyke has developed naturally-derived biomaterials, with particular emphasis on keratin-based materials for regenerative medicine applications, wound healing, and trauma. His work includes investigation into the solution behavior and self-assembly of keratin nanomaterials and their development into products for medical devices, tissue engineering, and drug and cell delivery. Van Dyke's background includes a BS in chemistry and biology from Central Michigan University, a PhD in Materials Science from the University of Cincinnati, and extensive experience in biomaterials research at institutions such as Southwest Research Institute, Wake Forest University School of Medicine, and Virginia Tech. He has published over 80 papers and book chapters, holds 34 issued US patents, and has more than 80 patents pending, many related to keratin biomaterials. He is also a co-founder of three startup companies and has interests in healthcare entrepreneurship, intellectual property strategy, and biomedical research.

Research topics

• Biochemistry
• Cell biology
• Chemistry
• Biology
• Pathology
• Biomedical engineering
• Internal medicine
• Medicine
• Bioinformatics
• Cancer research

Selected publications

• Collagen/kerateine multi-protein hydrogels as a thermally stable extracellular matrix for 3D <i>in vitro</i> models

  International Journal of Hyperthermia · 2021 · 20 citations

  This multi-protein C/KTN hydrogel shows promise for future studies involving thermal stress studies without compromising the 3D ECM environment or cell growth.

  PublisherDOI

• Keratose hydrogel for tissue regeneration and drug delivery

  Seminars in Cell and Developmental Biology · 2021-07-02 · 16 citations

  review
  PublisherDOI

• Keratin Promotes Differentiation of Keratinocytes Seeded on Collagen/Keratin Hydrogels

  Bioengineering · 2022-10-15 · 7 citations

  articleOpen access

  Keratinocytes undergo a complex process of differentiation to form the stratified stratum corneum layer of the skin. In most biomimetic skin models, a 3D hydrogel fabricated out of collagen type I is used to mimic human skin. However, native skin also contains keratin, which makes up 90% of the epidermis and is produced by the keratinocytes present. We hypothesized that the addition of keratin (KTN) in our collagen hydrogel may aid in the process of keratinocyte differentiation compared to a pur…

  PublisherOA PDFDOI

• Development of a Static Avascular and Dynamic Vascular Human Skin Equivalent Employing Collagen/Keratin Hydrogels

  International Journal of Molecular Sciences · 2024-05-03 · 5 citations

  articleOpen access

  One of the primary complications in generating physiologically representative skin tissue is the inability to integrate vasculature into the system, which has been shown to promote the proliferation of basal keratinocytes and consequent keratinocyte differentiation, and is necessary for mimicking representative barrier function in the skin and physiological transport properties. We created a 3D vascularized human skin equivalent (VHSE) with a dermal and epidermal layer, and compared keratinocyte…

  PublisherOA PDFDOI

• Recombinant keratin: Comprehensive review of synthesis, hierarchical assembly, properties, and applications

  Acta Biomaterialia · 2025-04-03 · 3 citations

  review
  PublisherDOI

Recent grants

• NIH Grant R41EB005900

  NIH · $100k · 2007

Frequent coauthors

• Anthony Atala

  56 shared

• Thomas L. Smith

  32 shared

• Shay Söker

  Wake Forest University

  30 shared

• James J. Yoo

  Forest Institute

  26 shared

• George J. Christ

  University of Virginia

  20 shared

• Sang Jin Lee

  Mokpo National University

  20 shared

• Paulina Sierpinski

  California Institute for Regenerative Medicine

  19 shared

• Justin M. Saul

  Caris Life Sciences (United States)

  17 shared

Similar researchers at University of Arizona

• Philipp Gutrufh-49
• Jil Tardiffh-37
• Urs Utzingerh-37