Mark Ainsworth
· Francis Wayland Professor of Applied Mathematics, Applied Mathematics AdvisorBrown University · Engineering
Active 1954–2026
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About
Mark Ainsworth is the Francis Wayland Professor of Applied Mathematics at Brown University. His research focuses on computational engineering, applying mathematical and computational techniques to solve complex engineering problems. As a faculty member at Brown University, he contributes to the Master’s in Data-Enabled Computational Engineering and Science program, emphasizing the integration of data-driven methods with computational modeling. He is actively involved in advancing the field of applied mathematics through his research and teaching, supporting students and colleagues in developing innovative solutions to engineering challenges. His work is characterized by a strong emphasis on computational methods and their application to real-world problems in engineering and science.
Research topics
- Medicine
- Internal medicine
- Emergency medicine
- Virology
- Pathology
- Physical therapy
- Immunology
- Biology
- Computational biology
- Pediatrics
Selected publications
The Lancet · 2021 · 1078 citations
The Lancet · 2021 · 520 citations
BACKGROUND: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. METHODS: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across t…
The Lancet Respiratory Medicine · 2022 · 417 citations
BACKGROUND: No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge. METHODS: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a pro…
The Lancet · 2022 · 382 citations
BACKGROUND: Casirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein, blocking viral entry into host cells. We aimed to evaluate the efficacy and safety of casirivimab and imdevimab administered in combination in patients admitted to hospital with COVID-19. METHODS: RECOVERY is a randomised, controlled, open-label platform trial comparing several possible treatments with usual care in pa…
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Cell · 2022 · 325 citations
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cell…
Recent grants
NIH · $71k
Neural Network Approximation of PDEs - Efficiency, Reliability and Quantifiable Accuracy
NSF · $495k · 2023–2027
Frequent coauthors
- 198 shared
Rachael A. Evans
- 173 shared
Christopher E. Brightling
NIHR Leicester Biomedical Research Centre
- 148 shared
Michael Marks
University of London
- 140 shared
Dhruv Parekh
University of Birmingham
- 129 shared
Louise V. Wain
University of Leicester
- 125 shared
Joanna C. Porter
University College London
- 120 shared
Casper Steenholdt
Herlev Hospital
- 116 shared
J. Kenneth Baillie
Roslin Institute
Education
- 2009
Teacher Training Program ( "Adjunktpædagogikum"), Faculty of Health and Medical Sciences
University of Copenhagen
- 1986
MD, Medical faculty
University of Copenhagen
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