Mark A. Borden

About

Mark A. Borden is a professor in the Paul M. Rady Mechanical Engineering Department at the University of Colorado Boulder. His research interests include colloid science, ultrasound, theranostics, and oxygen delivery. His laboratory investigates the science and engineering of microbubbles, nanodrops, and other colloidal suspensions for biomedical imaging and therapy. Current applications of his research include ultrasound molecular imaging, ultrasound image-guided drug delivery, and oxygen delivery. Borden's work also focuses on molecular-level details of interfacial transport phenomena related to engineered colloids. His laboratory develops medical technology aimed at aiding the diagnosis and treatment of diseases such as acute respiratory distress syndrome (ARDS), heart disease, and cancer. He has contributed to the commercialization of this technology by spinning out two companies, Respirogen Inc. and Advanced Microbubbles LLC, to translate his innovations into clinical settings. Borden has received numerous awards and recognitions for his contributions, including the NSF Career Award and the Department Outstanding Research Award. He is actively involved in the scientific community through various committees and symposium memberships.

Research topics

• Computer Science
• Medicine
• Biomedical engineering
• Chemistry
• Nanotechnology
• Nuclear medicine
• Thermodynamics
• Radiology
• Materials science
• Mechanics

Selected publications

• Microbubble Agents: New Directions

  Ultrasound in Medicine & Biology · 2020 · 179 citations

  Senior authorCorresponding
  DOI

• Microbubble Size and Dose Effects on Pharmacokinetics

  ACS Biomaterials Science & Engineering · 2022 · 50 citations

  Senior authorCorresponding

  Optimization of contrast-enhanced imaging and focused ultrasound therapy requires a comprehensive understanding of in vivo microbubble (MB) pharmacokinetics. Prior studies have focused pharmacokinetic analysis on indirect techniques, such as ultrasound imaging of the blood pool and gas chromatography of exhaled gases. The goal of this work was to measure the MB concentration directly in blood and correlate the pharmacokinetic parameters with the MB size and dose. MB volume dose (MVD) was chosen…

  DOI

• Bubble Inflation Using Phase-Change Perfluorocarbon Nanodroplets as a Strategy for Enhanced Ultrasound Imaging and Therapy

  Langmuir · 2020 · 33 citations

  Phase-change perfluorocarbon microdroplets were introduced over 2 decades ago to occlude downstream vessels in vivo. Interest in perfluorocarbon nanodroplets has recently increased to enable extravascular targeting, to rescue the weak ultrasound signal of perfluorocarbon droplets by converting them to microbubbles and to improve ultrasound-based therapy. Despite great scientific interest and advances, applications of phase-change perfluorocarbon agents have not reached clinical testing because o…

  DOI

• Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening

  Journal of Controlled Release · 2023-11-30 · 31 citations

  reviewOpen accessSenior author
  PublisherOA PDFDOI

• Comprehensive assessment of blood–brain barrier opening and sterile inflammatory response: unraveling the therapeutic window

  Scientific Reports · 2024-07-23 · 13 citations

  articleOpen accessSenior author

  Microbubbles (MBs) combined with focused ultrasound (FUS) has emerged as a promising noninvasive technique to permeabilize the blood-brain barrier (BBB) for drug delivery into the brain. However, the safety and biological consequences of BBB opening (BBBO) remain incompletely understood. This study aims to investigate the effects of two parameters mediating BBBO: microbubble volume dose (MVD) and mechanical index (MI). High-resolution MRI-guided FUS was employed in mouse brains to assess BBBO by…

  PublisherOA PDFDOI

Recent grants

• Ultrasound Molecular Imaging to Assess Therapeutic Response

  NIH · $2.0M · 2015–2021

• Lanthanide-lipids as MR Biosensors and Probes for Focused Ultrasound Surgery

  NSF · $300k · 2011–2014

• NIH Grant R01EB009066

  NIH · $1.2M · 2013

Frequent coauthors

• Paul A. Dayton

  54 shared

• Shashank R. Sirsi

  The University of Texas at Dallas

  40 shared

• Kang-Ho Song

  University of Colorado Boulder

  23 shared

• Todd W. Murray

  23 shared

• Katherine W. Ferrara

  Stanford University

  23 shared

• Jameel A. Feshitan

  20 shared

• Awaneesh Upadhyay

  University of Colorado Boulder

  17 shared

• Virginie Papadopoulou

  University of North Carolina at Chapel Hill

  17 shared

Awards & honors

• Department Outstanding Service Award, 2019
• Department Outstanding Research Award, 2014
• McLagan Family Faculty Fellow, 2013-2016
• Dean’s Faculty Fellowship, 2014
• Nicholas Rome Faculty Fellow, 2010-2013

Similar researchers at University of Colorado Boulder

• Daven Henzeh-75
• Francois Barthelath-49
• Michael Hanniganh-47