Marc Hellerstein

About

Marc Hellerstein is a Professor of Nutritional Sciences & Toxicology and holds the Robert C. and Veronica Atkins Chair in Metabolic Nutrition. He is associated with the Department of Nutritional Sciences & Toxicology at the University of California, Berkeley, and is part of the Center for Computational Biology. His role involves research and academic contributions in the fields of nutritional sciences, toxicology, and metabolic nutrition, with a focus on computational biology and related areas.

Research topics

• Gastroenterology
• Pathology
• Medicine
• Internal medicine
• Endocrinology

Selected publications

• Adhesion-mediated mechanosignaling forces mitohormesis

  Cell Metabolism · 2021-05-20 · 136 citations

  articleOpen access
  PublisherOA PDFDOI

• What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?

  Vaccine X · 2020-08-27 · 87 citations

  reviewOpen access1st authorCorresponding

  The first SARS-CoV-2 vaccine(s) will likely be licensed based on neutralizing antibodies in Phase 2 trials, but there are significant concerns about using antibody response in coronavirus infections as a sole metric of protective immunity. Antibody response is often a poor marker of prior coronavirus infection, particularly in mild infections, and is shorter-lived than virus-reactive T-cells; strong antibody response correlates with more severe clinical disease while T-cell response is correlate…

  PublisherDOI

• Inhibition of fatty acid synthase with <scp>FT‐4101</scp> safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two early‐phase randomized trials

  Diabetes Obesity and Metabolism · 2020 · 53 citations

  AIMS: To assess the therapeutic potential of fatty acid synthase (FASN) inhibition with FT-4101, a potent, selective, orally bioavailable, small-molecule by (a) evaluating the dose-response of single FT-4101 doses (3, 6 and 9 mg) on hepatic de novo lipogenesis (DNL) in healthy participants (Study 1) and (b) demonstrating the safety, tolerability and efficacy on hepatic steatosis after 12 weeks of FT-4101 dosing in patients with non-alcoholic fatty liver disease (NAFLD; Study 2). MATERIALS AND ME…

  PublisherOA PDFDOI

• Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice

  Journal of Clinical Investigation · 2024-10-15 · 7 citations

  articleOpen access

  Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol, the penultimate step of triglyceride synthesis, which is essential for lipid storage. Herein we found that adipose tissue LPIN1 expression is decreased in people with obesity compared with lean subjects, and low LPIN1 expression correlated with multi…

  PublisherOA PDFDOI

• Change in D3Cr muscle mass in oldest old men and its association with changes in grip strength and walking speed

  PLoS ONE · 2025-04-01 · 5 citations

  articleOpen accessCorresponding

  BACKGROUND: The use of lean soft tissue (LST) mass as a surrogate measurement of skeletal muscle mass (SMM) has led to the conclusion that muscle loss is poorly related to functional decline. We hypothesized that when using a more accurate measure of SMM determined by D3-creatine dilution (D3Cr), longitudinal changes in SMM will be similar in magnitude to changes in strength and physical performance and that skeletal muscle mass will partially mediate the relationship of age with these outcomes.…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R37AI043866

  NIH · $3.9M · 2013

• NIH Grant P01HD040543

  NIH · $12.0M · 2008

• NIH Grant R01AI043866

  NIH · $1.1M · 2002

Frequent coauthors

• Richard A. Neese

  University of California System

  144 shared

• Scott Turner

  Pliant (United States)

  140 shared

• Mahalakshmi Shankaran

  84 shared

• William J. Evans

  University of California, Berkeley

  82 shared

• Teresa W.‐M. Fan

  University of Kentucky

  64 shared

• Andrea E. Spencer

  64 shared

• Charles R. Owens

  The Medical Center of Aurora

  64 shared

• Courtney Pollard

  Piedmont Cancer Institute

  64 shared

Labs

• Center for Computational BiologyPI

Similar researchers at University of California, Berkeley

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• Daniel Rokhsarh-155
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