Marc Chevrette

About

Marc Chevrette is an Assistant Professor in the Department of Plant Pathology at the University of Wisconsin-Madison. He holds a PhD in Genetics and MSc degrees in Genetics and Biotechnology (Bioengineering), all from the University of Wisconsin-Madison, as well as a BSc in Molecular Biology & Bioinformatics from Rensselaer Polytechnic Institute. His research focuses broadly on secondary metabolism and its relation to interspecies interactions. He studies secondary metabolism in evolution, including genome mining and the development of computational tools to identify and characterize biosynthetic gene clusters (BGCs) in microbial genomes. His work explores the diversity and distribution of BGCs and biosynthetic enzymes across evolutionary space, as well as ancestral reconstruction of biosynthetic domains, genes, and pathways. Chevrette's research also investigates the evolutionary dynamics of enzyme specificity and promiscuity in natural systems, secondary metabolites from host-associated microbiomes such as amphibian skin, insect exoskeleton, and the rhizosphere, and soil bacteria, including those from Tiny Earth. Additionally, his lab employs metatranscriptomics and metametabolomics of synthetic microbial communities to understand genetic and regulatory mechanisms of secondary metabolite expression and interspecies interactions.

Research topics

• Biology
• Computer Science
• Bioinformatics
• Computational biology
• Biochemistry
• Genetics
• Microbiology
• Data science
• Sociology
• Ecology

Selected publications

• A marine microbiome antifungal targets urgent-threat drug-resistant fungi

  Science · 2020 · 172 citations

  Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug-resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from…

  DOI

• A community resource for paired genomic and metabolomic data mining

  Nature Chemical Biology · 2021 · 129 citations

  biosynthetic origins and metabolite structures.

  DOI

• Microbiome composition modulates secondary metabolism in a multispecies bacterial community

  Proceedings of the National Academy of Sciences · 2022 · 107 citations

  1st authorCorresponding

  , suggesting that koreenceine represses siderophore production. Results from this model community show that bacterial BGC expression and chemical output depend on the identity and biosynthetic capacity of coculture partners, suggesting community composition and microbiome interactions may shape the regulation of secondary metabolism in nature.

  DOI

• Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery

  mBio · 2021 · 61 citations

  The world faces two seemingly unrelated challenges-a shortfall in the STEM workforce and increasing antibiotic resistance among bacterial pathogens. We address these two challenges with Tiny Earth, an undergraduate research course that excites students about science and creates a pipeline for antibiotic discovery.

  DOI

• Bacillibactins E and F from a Marine Sponge-Associated <i>Bacillus</i> sp.

  Journal of Natural Products · 2020 · 24 citations

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  PublisherOA PDFDOI

Frequent coauthors

• Cameron R. Currie

  University of Wisconsin–Madison

  44 shared

• Jo Handelsman

  University of Wisconsin–Madison

  35 shared

• Tim S. Bugni

  University of Wisconsin–Madison

  23 shared

• Timothy J. Triche

  Van Andel Institute

  20 shared

• Amanda Hurley

  Wisconsin Institutes for Discovery

  20 shared

• Casey S. Greene

  18 shared

• Francisco Barona‐Gómez

  Center for Research and Advanced Studies of the National Polytechnic Institute

  18 shared

• Gabriel L. Lozano

  Wisconsin Institutes for Discovery

  16 shared

Labs

• Chevrette LabPI

Education

• Ph.D., Plant Pathology

  University of Wisconsin-Madison

  1990

• M.S., Plant Pathology

  University of Wisconsin-Madison

  1986

• B.S., Botany

  University of Wisconsin-Madison

  1982

Similar researchers at University of Wisconsin-Madison

• Paul Ahlquisth-110
• Andrew Benth-60