Man-Yau (Joseph) Chan

About

Man-Yau (Joseph) Chan is an Assistant Professor in the Department of Geography at The Ohio State University. He holds a PhD in Meteorology and Atmospheric Sciences from The Pennsylvania State University, obtained in 2022, and a BS in Physics with Honors from the National University of Singapore, earned in 2017. His research is dedicated to improving Earth system forecasts and data, which are crucial for socioeconomic activities and disaster mitigation. He specializes in developing and applying Ensemble Data Assimilation (EnsDA), a geospatial Big Data Fusion technique that combines measurements and computer models to enhance weather, ocean, and land forecasting systems. His interests include exploring new applications of existing observations, creating novel and practical EnsDA algorithms, developing better Earth System datasets, understanding error growth in Earth System models, and finding accessible ways to train future generations on EnsDA.

Research topics

• Biochemistry
• Chemistry
• Cell biology
• Biology
• Computational biology
• Materials science
• Organic chemistry
• Physics
• Cancer research
• Nanotechnology

Selected publications

• xSCYTE: Express Single-frame Cytometer through Tomographic Phase

  arXiv (Cornell University) · 2022-02-08 · 18 citations

  preprintOpen access

  Rapid, comprehensive, and accurate cell phenotyping without compromising viability, is crucial to many important biomedical applications, including stem-cell therapy, drug screening, and liquid biopsy. Typical image cytometry methods acquire two-dimensional (2D) fluorescence images, where the fluorescence labelling process may damage living cells, and the information from 2D images is not comprehensive enough for precise cell analysis. Although three-dimensional (3D) label-free image cytometry h…

  PublisherOA PDFDOI

• Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex

  Communications Biology · 2023-01-16 · 11 citations

  articleOpen accessSenior author

  The 22nd genetically encoded amino acid, pyrrolysine, plays a unique role in the key step in the growth of methanogens on mono-, di-, and tri-methylamines by activating the methyl group of these substrates for transfer to a corrinoid cofactor. Previous crystal structures of the Methanosarcina barkeri monomethylamine methyltransferase elucidated the structure of pyrrolysine and provide insight into its role in monomethylamine activation. Herein, we report the second structure of a pyrrolysine-con…

  PublisherOA PDFDOI

• High Throughput Phage Display Screening Identified Peptide Inhibitors Targeting the α-Synuclein for Parkinson’s Disease Treatment

  2024-09-20

  articleOpen access
  PublisherDOI

Recent grants

• NIH Grant R21AI081291

  NIH · $380k · 2011

• NIH Grant R01GM061796

  NIH · $2.4M · 2010

• NIH Grant F32GM015006

  NIH · $73k

Frequent coauthors

• Marianne M. Lee

  Chinese University of Hong Kong

  29 shared

• Judith C. Gallucci

  The Ohio State University

  25 shared

• Clara E. Isaza

  University of Puerto Rico-Mayaguez

  22 shared

• Tomasz Fekner

  20 shared

• Bing Hao

  UConn Health

  20 shared

• Shao‐Ching Hung

  19 shared

• Pramatha Payra

  19 shared

• Wai-Him Kwok

  Hong Kong Jockey Club

  19 shared

Education

• Postdoctoral Fellow, Chemistry

  California Institute of Technology

  1995

• PhD, Chemistry

  University of California, Berkeley

  1991

• B.S., Chemistry

  Harvey Mudd College

  1986

Similar researchers at Ohio State University

• Zhengyu Liuh-86
• Bryan Markh-68
• Harvey Millerh-49