M. Gregory Forest

About

M. Gregory Forest is the Grant Dahlstrom Distinguished Professor of Mathematics at the University of North Carolina at Chapel Hill. He holds joint appointments in Applied Physical Sciences and Biomedical Engineering and serves as the Director of the Carolina Center for Interdisciplinary Applied Mathematics. Additionally, he is the Associate Director of the Statistical & Applied Mathematical Sciences Institute. His dissertation was titled 'Multiple Phase Averaging of Periodic Soliton Equations,' and he was advised by David McLaughlin with Hermann Flaschka as co-advisor. His research focuses on applied mathematics, particularly in the areas related to interdisciplinary applied mathematics, soliton equations, and phase averaging.

Research topics

• Biology
• Computational biology
• Genetics
• Biophysics
• Cell biology

Selected publications

• LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus

  Mucosal Immunology · 2020-03-02 · 29 citations

  articleOpen access
  PublisherOA PDFDOI

• Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking

  Molecular Biology of the Cell · 2020-06-29 · 26 citations

  articleOpen access

  The spatial structure and physical properties of the cytosol are not well understood. Measurements of the material state of the cytosol are challenging due to its spatial and temporal heterogeneity. Recent development of genetically encoded multimeric nanoparticles (GEMs) has opened up study of the cytosol at the length scales of multiprotein complexes (20-60 nm). We developed an image analysis pipeline for 3D imaging of GEMs in the context of large, multinucleate fungi where there is evidence o…

  PublisherOA PDFDOI

• Statistical mechanics of chromosomes:<i>in vivo</i>and<i>in silico</i>approaches reveal high-level organization and structure arise exclusively through mechanical feedback between loop extruders and chromatin substrate properties

  Nucleic Acids Research · 2020 · 20 citations

  The revolution in understanding higher order chromosome dynamics and organization derives from treating the chromosome as a chain polymer and adapting appropriate polymer-based physical principles. Using basic principles, such as entropic fluctuations and timescales of relaxation of Rouse polymer chains, one can recapitulate the dominant features of chromatin motion observed in vivo. An emerging challenge is to relate the mechanical properties of chromatin to more nuanced organizational principl…

  PublisherOA PDFDOI

• The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

  UNC Libraries · 2024-08-22 · 6 citations

  articleOpen access

  The binding site barrier (BSB) was originally proposed to describe the binding behavior of antibodies to cells peripheral to blood vessels, preventing their further penetration into the tumors. Yet, it is revisited herein to describe the intratumoral cellular disposition of nanoparticles (NPs). Specifically, the BSB limits NP diffusion and results in unintended internalization of NPs by stroma cells localized near blood vessels. This not only limits the therapeutic outcome but also promotes adve…

  PublisherDOI

• Flagellum pumping efficiency in shear-thinning viscoelastic fluids

  Journal of Fluid Mechanics · 2024-11-11 · 3 citations

  articleOpen access

  Microorganism motility often takes place within complex, viscoelastic fluid environments, e.g., sperm in cervicovaginal mucus and bacteria in biofilms. In such complex fluids, strains and stresses generated by the microorganism are stored and relax across a spectrum of length and time scales and the complex fluid can be driven out of its linear response regime. Phenomena not possible in viscous media thereby arise from feedback between the swimmer and the complex fluid, making swimming efficienc…

  PublisherOA PDFDOI

Recent grants

• Collaborative Research: Collaborative Proposal for Mathematics & Computation of Nano-Composite Flows & Properties

  NSF · $213k · 2006–2009

• Collaborative Research: A Molecular-to-Continuum, Data-Driven Strategy for Mucus Transport Modeling

  NSF · $100k · 2014–2017

• A Mathematical-Experimental Strategy to Discern the Molecular Basis of "Successful Mucus"

  NSF · $960k · 2015–2019

Frequent coauthors

• Samuel K. Lai

  University of North Carolina at Chapel Hill

  89 shared

• David B. Hill

  North Carolina State University

  83 shared

• Ruhai Zhou

  Xiangya Hospital Central South University

  50 shared

• Ronit Freeman

  Applied Physical Sciences (United States)

  45 shared

• Timothy Wessler

  43 shared

• Paula A. Vasquez

  University of South Carolina

  38 shared

• Jay Newby

  University of Alberta

  36 shared

• Matthew R. Markovetz

  University of North Carolina at Chapel Hill

  36 shared

Similar researchers at University of North Carolina at Chapel Hill

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• Jason Roseh-94
• Benjamin P. Bermanh-71