Louise Abbott

Adult neurogenesis in the mammalian dentate gyrus

Anatomia Histologia Embryologia · 2019-09-30 · 166 citations

Earlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. This review focuses only on new neuron formation in the dentate gyrus of the hippocampus. During…

Mercury Toxicity and Neurogenesis in the Mammalian Brain

International Journal of Molecular Sciences · 2021-07-14 · 46 citations

The mammalian brain is formed from billions of cells that include a wide array of neuronal and glial subtypes. Neural progenitor cells give rise to the vast majority of these cells during embryonic, fetal, and early postnatal developmental periods. The process of embryonic neurogenesis includes proliferation, differentiation, migration, the programmed death of some newly formed cells, and the final integration of differentiated neurons into neural networks. Adult neurogenesis also occurs in the…

Effect of Cadmium and Nickel Exposure on Early Development in Zebrafish (Danio rerio) Embryos

Water · 2020-10-26 · 37 citations

Exposure to even low concentrations of heavy metals can be toxic to aquatic organisms, especially during embryonic development. Thus, this study aimed to investigate the toxicity of nickel and cadmium in zebrafish (Danio rerio) embryos exposed to environmentally relevant concentrations of each metal alone or in combination from 4 h through to 72 h postfertilization. Neither metal altered survival, but individual and combined exposures decreased hatching rate. Whereas cadmium did not affect total…

Effects of methyl mercury exposure on pancreatic beta cell development and function

Journal of Applied Toxicology · 2016-09-04 · 36 citations

Methyl mercury is an environmental contaminant of worldwide concern. Since the discovery of methyl mercury exposure due to eating contaminated fish as the underlying cause of the Minamata disaster, the scientific community has known about the sensitivity of the developing central nervous system to mercury toxicity. Warnings are given to pregnant women and young children to limit consumption of foods containing methyl mercury to protect the embryonic, fetal and postnatally developing central nerv…

Compositional analysis of genetically modified corn events (NK603, MON88017×MON810 and MON89034×MON88017) compared to conventional corn

Food Chemistry · 2014-12-20 · 21 citations