Ling Cai
· Associate Professor of PathologyDuke University · Pathology
Active 1995–2026
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
Ling Cai is an Associate Professor of Pathology at Duke University and a member of the Duke Cancer Institute. She is based at 905 S LaSalle St, GSRB1, Rm 2077, Durham, NC 27710. Her role involves research and teaching within the Department of Pathology, contributing to the academic and clinical missions of Duke University. As a faculty member, she is engaged in advancing understanding in her field, although specific research focus areas are not detailed on the page.
Research topics
- Biology
- Genetics
- Cell biology
- Chemistry
- Cancer research
- Biochemistry
- Surgery
- Organic chemistry
- Nanotechnology
- Materials science
Selected publications
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
Nature Communications · 2025-07-01 · 2 citations
articleOpen accessMono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear. Here, we report that an evolutionarily conserved tandem Tudor domain (TTD) in BAHCC1 (BAHCC1TTD) selectively reads H4K20me1 for facilitating replication origin activation and DNA replication. Our biochemical, structural, genomic and cellular analyses demonstrate that BAHCC1TTD preferentially recogni…
MedScience · 2026-02-01 · 1 citations
articleOpen accessMono-ubiquitination of histone H2A at lysine 119 (H2AK119Ub) is deposited by the Polycomb repressive complex 1 (PRC1) and represents an abundant post-translational modification (PTM) of histones. H2AK119Ub is crucially involved in the regulation of a wide range of biological processes, including organization of the genome into distinct functional domains, gene silencing, and the maintenance of cell identities during development, among others. Biochemically, the deposition and removal of H2AK119U…
Biochemical Journal · 2025-06-19 · 1 citations
articleOpen accessThe H3K27me-specific methyltransferase enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of the repressive complex Polycomb repressive complex 2. EZH2 is typically implicated in transcriptional silencing, but it can also activate gene expression. Here, we show that EZH2 contains three adjacent transactivation domains (EZH2TAD) that are recognized by the TAZ2 domain of the transcriptional coactivator and acetyltransferase p300 (p300TAZ2). Binding interfaces identified by chemical shif…
bioRxiv (Cold Spring Harbor Laboratory) · 2025-08-06
preprintOpen accessSenior authorCorrespondingAbstract Genetic and epigenetic aberrations often act in concert to establish oncogenic transcriptomic programs in aggressive cancers. For example, the development of castration-resistant prostate cancer (CRPC), an advanced prostate cancer form, is closely associated with over-expression and/or hyper-activation of transcription factors (TFs) such as Androgen Receptor (AR) and Yin Yang 1 (YY1), as well as p300, a prominent histone acetyltransferase. How exactly these cancer-related lesions are co…
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
UNC Libraries · 2025-07-25
articleOpen access
Recent grants
The Role of YY1 in Castration-Resistant Prostate Cancer
NIH · $2.1M · 2021–2026
Frequent coauthors
- 238 shared
Ralph J. DeBerardinis
The University of Texas Southwestern Medical Center
- 195 shared
John D. Minna
- 144 shared
Guanghua Xiao
- 143 shared
Yang Xie
- 80 shared
Luc Girard
- 62 shared
Jin Chen
- 52 shared
Gang Greg Wang
Duke University
- 50 shared
Brandon Faubert
University of Chicago
Similar researchers at Duke University
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Ling Cai
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup