About

Professor Lin Zhu is associated with the Texas A&M Irma Lerma Rangel College of Pharmacy. The provided page text does not include specific details about her research focus, background, or key contributions. Therefore, a detailed professional biography cannot be extracted from the given information.

Research topics

• Materials science
• Nanotechnology
• Composite material
• Polymer chemistry
• Chemical engineering
• Polymer science
• Chromatography
• Chemistry

Selected publications

• Effects of Nighttime Warming on Nitrogen Uptake and Utilization of Winter Wheat ( <i>Triticum aestivum</i> L.)

  Journal of Agronomy and Crop Science · 2026-05-01

  article1st author

  ABSTRACT The effect of long‐term climate warming on nitrogen (N) uptake and utilisation in wheat ( Triticum aestivum L.) systems is not well understood. We conducted research on it using an in situ nighttime warming (NW) experiment at heading and maturity stages of 2022–2024 and early 2015–2016 wheat growth seasons. NW significantly reduced wheat yield by 31.4% in the 2015–2016 season and remained unchanged in the 2022–2023 and 2023–2024 seasons. It significantly increased the 3‐year total biomass of wheat at heading and maturity stages (excluding the maturity stage of the 2022–2023 season) by 11.4%–29.1%. NW significantly increased N accumulation in grains and plants at heading and maturity stages in the 2015–2016 and 2023–2024 seasons. NW significantly increased N translocation before wheat flowering (except for the 2022–2023 season). However, it significantly increased N translocation from stems by 42.2%–547.4% and its contribution to N accumulation in grains (CNAG), but decreased those from leaves by 10.0%–22.6% and its CNAG for 3 seasons. NW also significantly increased N accumulation after wheat flowering and its CNAG for 3 seasons. NW increased N uptake efficiency of winter wheat by 7.8%–36.9% and decreased N use efficiency by 6.1%–49.9%, with no significant difference observed in the 2022–2023 season. This study indicates that although the effect of NW on N uptake and utilisation in wheat varied among different seasons, the impact of NW on N dynamics should be considered to recommend reasonable application of N fertiliser under climate warming scenarios to ensure sustainable wheat production and minimise potential environmental pollution.

  PublisherDOI

• Therapeutic effects of mannose modified ciprofloxacin and matrine liposome on intracellular bacterial infections from “superficial to deep”

  Journal of Drug Delivery Science and Technology · 2026-05-11

  article
  PublisherDOI

• Dynamic functional connectivity differences between insomnia and comorbid insomnia with depression: A neuroimaging study of brain stability

  Biological Psychology · 2025-06-16 · 1 citations

  article
  PublisherDOI

• Photoredox Hydroacylative Dearomatization of Indoles with Aromatic Carboxylic Acids

  Advanced Synthesis & Catalysis · 2025-01-07 · 7 citations

  article

  Abstract Herein we reported for the first time a photocatalytic dearomative hydroacylation reaction of electron‐deficient indoles with readily available aromatic acids through a phosphoranyl radical‐assisted deoxygenative process. A range of racemic and optically active 2‐acylindoline derivatives were obtained in good yields (up to 94%) with good diastereoselectivity. The synthetic robustness is highlighted by the enantioselective dearomatization of indoles and the late‐stage modification of natural products and pharmaceutical molecules. This protocol features broad substrate scope and mild reaction conditions, providing a reliable entry to developing deoxygenative strategies in dearomatization reactions. Preliminary mechanistic studies and DFT calculations suggest that a Giese‐type radical addition pathway should be involved.

  PublisherDOI

• LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis

  PLoS ONE · 2025-01-17 · 3 citations

  articleOpen access1st authorCorresponding

  Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 75%-85% of PHC. LARP3 is aberrantly expressed in multiple cancers. We found that it is significantly highly expressed in the liver cancer tissues of HCC patients, but the exact role and specific mechanism of this abnormal expression are not yet clear. In this study, through bioinformatics analysis, we concluded that LARP3 expression is associated with a poor prognosis for patients with HCC. Through cellular experiments such as gene editing and phenotypic functions, we found that LARP3 promotes the occurrence and development of HCC and inhibits apoptosis. Finally, through biological means such as RNA sequencing, flow cytometry, western blotting, and the construction of a subcutaneous tumorigenesis model in nude mice, we concluded that inhibition of HCC apoptosis by LARP3 is related to LARP3 negatively regulating ROS level and inhibiting the PI3K/c-Fos/apoptosis axis. This study will provide potential targets for the treatment of HCC.

  PublisherOA PDFDOI

• Tropomodulin‐1—From the actin slow‐growing end to multifunctional roles

  FEBS Letters · 2025-10-22

  reviewOpen access

  Tropomodulin-1 (TMOD1) is a key regulator of actin filament dynamics that functions as an actin-binding protein. It specifically caps the slow-growing (pointed) ends of actin filaments, and the interaction is further stabilized by tropomyosin (TPM). By modulating actin monomer polymerization and depolymerization, TMOD1 critically controls filament length, thereby maintaining both the stability and plasticity of actin-based structures. Emerging evidence has highlighted the participation of TMOD1 in diverse cellular processes, such as cytoskeletal organization, neurite outgrowth, cell motility, and cancer progression. This review summarizes recent advances in TMOD1 research and offers a comprehensive overview of its multifaceted biological roles and implications for future studies.

  PublisherOA PDFDOI

• Immune-related deubiquitylation spectrum of microsatellite stability colorectal cancer reveals USP7 as a potential immunotherapeutic target

  Molecular Cancer · 2025-12-18 · 3 citations

  articleOpen access

  The efficacy of immune checkpoint inhibitors (ICIs) in microsatellite stable colorectal cancer (MSS CRC) remains limited, highlighting an urgent need for predictive biomarkers. Through multi-omics analysis, we identified two novel MSS CRC subtypes, termed DUB-H and DUB-L. The DUB-L subtype exhibited an inflamed tumor immune microenvironment, a superior response to immune therapy, and better recurrence-free survival (RFS) compared to DUB-H. The classifier gene USP7 was selected as a gene of interest due to its specific expression profile, which is highly expressed in MSS CRC but not in microsatellite instability-high (MSI-H) tumors, and strongly correlated with suppressed immune infiltration. Large-scale clinical analyses confirmed associations between high USP7 expression, microsatellite stability, specific consensus molecular subtypes (CMS), and unfavorable prognosis. Single-cell analysis and multiplex immunofluorescence validated an immune-desert phenotype in USP7-high MSS tumors. Mechanistically, USP7 knockdown in MSS CRC cells enhances the secretion of T-cell-recruiting chemokines (CXCL9/10/11), promoting CD8⁺ T cell recruitment and cytotoxicity in vitro. In vivo experiments demonstrated that USP7 blockade enhanced the efficacy of anti-PD-1 treatment in MSS CRC models by remodeling the tumor immune microenvironment, increasing infiltration and function of CD8⁺ T and NK cells. Consistently, low USP7 expression is associated with a better response to anti-PD-1 therapy. Overall, we propose a novel DUB-based classification system for MSS CRC and demonstrate that targeting USP7 may overcome immunotherapy resistance by converting immunologically “cold” tumors into “hot” ones.

  PublisherDOI

• Innovative Electrochemical Sensors for Pesticide Residue Detection: Nanomaterials, Miniaturization, and Intelligent Data Analysis

  The Chemical Record · 2025-05-29 · 8 citations

  review

  The increasing use of pesticides in agriculture has raised concerns over their residues in food products, necessitating the development of effective detection methods to ensure consumer safety and environmental sustainability. This review covers cutting- edge advances in electrochemical sensors for pesticide residue detection, emphasizing their significance in addressing the limitations of traditional methods. The authors summarize recent progress in sensor materials for enhancing detection sensitivity and selectivity, including metal-organic frameworks, single-atom materials, MXene-based materials, and conductive polymers and so on. The review highlights the progress in sensor miniaturization and portability, enabling on-site and real-time monitoring through the integration with microfluidic devices and wearable technology. It discusses the challenges and strategies for simultaneous detection of multiple pesticide residues to enhance efficiency. The influence of environmental factors on sensor performance is analyzed, and adaptive technologies are proposed to stabilize sensor performance under varying conditions. Moreover, the integration of big data and artificial intelligence in electrochemical sensing is examined, showing its potential in intelligent data analysis and automation. The review concludes by identifying the current challenges and future directions in electrochemical sensing for pesticide residues, suggesting that innovative sensor technologies hold the promise of transforming food safety monitoring and environmental protection.

  PublisherDOI

• T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

  Advanced Science · 2025-11-05 · 2 citations

  articleOpen access

  Locally advanced rectal cancer (LARC) presents significant treatment challenges, particularly in microsatellite stable (MSS) patients, who often show limited response to immunotherapy. In these cases, neoadjuvant chemoradiotherapy (neoCRT) followed by surgery remains the recommended approach. However, the response to neoCRT varies significantly among LARC patients. In this study, the role of the tumor microenvironment (TME) is explored, focusing on early-stage exhausted T cells (early-Tex) and tertiary lymphoid structures (TLS), in predicting neoCRT response in MSS LARC. Through multi-omics analyses, it is found that immune features of the TME, rather than mutational status, are more closely associated with treatment response. Within the TME, it is observed that early-Tex cells, a subset with both similarities and distinct differences compared to previously described precursor exhausted T (Tpex) cells, are enriched in responders and correlated with favorable treatment outcomes. Additionally, it is identified that TLSs are more abundant, activated, and mature in responders compared to non-responders. LAMP3⁺ dendritic cells (DCs) play a pivotal role in suppressing TLS formation, with IRF8 as a key transcriptional regulator, which may ultimately affect therapeutic response. These findings suggest early-Tex cells and modulation of TLS by LAMP3⁺ DCs can serve as indicators for optimizing neoCRT in MSS LARC.

  PublisherDOI

• Characterization and risk-quantification of antibiotic resistome in grain-based and non-grain cropping soils

  Environmental Pollution · 2025-03-29 · 1 citations

  article
  PublisherDOI

Recent grants

• Improving tumor specificity and overcoming drug resistance of proteasome inhibitors by a dual-targeted drug delivery system

  NIH · $444k · 2018–2023

Frequent coauthors

• Handong Wang

  Second Military Medical University

  91 shared

• Qiang Chen

  Northwestern Polytechnical University

  69 shared

• Jia Yang

  46 shared

• Hao Pan

  Nanjing University

  41 shared

• Gang Qin

  Institute of Physics

  38 shared

• Jiao Wang

  Yantai Institute of Coastal Zone Research

  36 shared

• Xiangjun Ji

  Nanjing University

  32 shared

• Meng‐Liang Zhou

  30 shared

Labs

• Pharmaceutical SciencesPI

Education

• Ph.D., Pharmaceutical Sciences

  University of Tennessee Health Science Center

  2010

• M.S.

  China Pharmaceutical University

  2003

• B.E.

  China Pharmaceutical University

  1997

Awards & honors

• Presidential Impact Fellow