Lea Hildebrandt Ruiz

About

Lea Hildebrandt Ruiz is an Associate Professor in the Department of Chemical Engineering at The University of Texas at Austin. She holds dual Ph.D. degrees in Chemical Engineering and Engineering and Public Policy from Carnegie Mellon University, both earned in 2011, and a B.S. in Chemical Engineering from the California Institute of Technology, obtained in 2006. Her academic background combines rigorous training in chemical engineering with a strong foundation in public policy, reflecting an interdisciplinary approach to her research and teaching. The information provided does not include specific details about her research focus or key contributions.

Research topics

• Chemistry
• Cell biology
• Atmospheric sciences
• Environmental science
• Meteorology
• Inorganic chemistry
• Environmental chemistry
• Biology
• Organic chemistry
• Climatology

Selected publications

• Multiphase Chemistry Controls Inorganic Chlorinated and Nitrogenated Compounds in Indoor Air during Bleach Cleaning

  Environmental Science & Technology · 2020 · 154 citations

  ) mixing ratios during bleach cleaning reported herein are likely detrimental to human health.

  DOI

• Effect of aerosol composition on the performance of low-cost optical particle counter correction factors

  Atmospheric measurement techniques · 2020 · 142 citations

  Abstract. There is considerable interest in using low-cost optical particle counters (OPCs) to supplement existing routine air quality networks that monitor particle mass concentrations. In order to do this, low-cost OPC data need to be comparable with particle mass reference instrumentation; however, there is currently no widely agreed upon methodology to accomplish this. Aerosol hygroscopicity is known to be a key parameter to consider when correcting particle mass concentrations derived from…

  DOI

• Sources and atmospheric dynamics of organic aerosol in New Delhi, India: insights from receptor modeling

  Atmospheric chemistry and physics · 2020 · 90 citations

  Senior authorCorresponding

  Abstract. Delhi, India, is the second most populated city in the world and routinely experiences some of the highest particulate matter concentrations of any megacity on the planet, posing acute challenges to public health (World Health Organization, 2018). However, the current understanding of the sources and dynamics of PM pollution in Delhi is limited. Measurements at the Delhi Aerosol Supersite (DAS) provide long-term chemical characterization of ambient submicron aerosol in Delhi, with near…

  DOI

• RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde

  Scientific Reports · 2020 · 47 citations

  Formaldehyde is an environmental and occupational chemical carcinogen implicated in the damage of proteins and nucleic acids. However, whether formaldehyde provokes modifications of RNAs such as 8-oxo-7,8-dihydroguanine (8-oxoG) and the role that these modifications play on conferring long-term adverse health effects remains unexplored. Here, we profile 8-oxoG modifications using RNA-immunoprecipitation and RNA sequencing (8-oxoG RIP-seq) to identify 343 RNA transcripts heavily enriched in oxida…

  DOI

• Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes

  Communications Biology · 2020 · 35 citations

  The impact of environmentally-induced chemical changes in RNA has been fairly unexplored. Air pollution induces oxidative modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG) in RNAs of lung cells, which could be associated with premature lung dysfunction. We develop a method for 8-oxoG profiling using immunocapturing and RNA sequencing. We find 42 oxidized transcripts in bronchial epithelial BEAS-2B cells exposed to two air pollution mixtures that recreate urban atmospheres. We show that the…

  DOI

Recent grants

• Collaborative Research: ICARUS - Index of Chamber Atmospheric Research in the United States

  NSF · $73k · 2017–2021

• Collaborative Research: A Halogen Oxidant Flow Reactor: Development and Use in Laboratory and Field Studies

  NSF · $191k · 2019–2023

• RAPID: COVID Response: Identifying practices that minimize exposure to disinfection byproducts

  NSF · $190k · 2020–2021

Frequent coauthors

• Joshua S. Apte

  University of California, Berkeley

  41 shared

• Sahil Bhandari

  Environmental Defense Fund

  34 shared

• Gazala Habib

  Indian Institute of Technology Delhi

  33 shared

• Shahzad Gani

  The University of Texas at Austin

  30 shared

• Kanan Patel

  26 shared

• Dongyu Wang

  Southwest University of Science and Technology

  24 shared

• Zainab Arub

  23 shared

• J. L. Jiménez

  18 shared

Labs

• Lea Hildebrandt Ruiz LabPI

Education

• B.S., Chemical Engineering

  California Institute of Technology

  2006

• Ph.D., Chemical Engineering and Engineering & Public Policy

  Carnegie Mellon University

  2011

Awards & honors

• James J. Morgan Early Career Award, American Chemical Societ…
• Early Career Award – American Institute of Chemical Engineer…
• CAREER Award, U.S. National Science Foundation (2017–2022)
• Postdoctoral Research Fellowship – National Science Foundati…
• Graduate Research Fellowship – EPA (2010–2011)

Similar researchers at University of Texas at Austin

• George Georgiouh-107
• Keith Johnstonh-106
• James Chelikowskyh-87