Laura Niedernhofer
· ProfessorUniversity of Minnesota · Biochemistry, Molecular Biology, and Biophysics
Active 1987–2024
About
Laura Niedernhofer, MD, PhD, joined the University of Minnesota in July 2018 to direct the Masonic Institute on the Biology of Aging and Metabolism (MiBAM) and the Medical Discovery Team on the Biology of Aging. She is a professor in the Department of Biochemistry, Molecular Biology and Biophysics. Her expertise is in DNA damage and repair, genome instability disorders, cellular senescence, and aging. Her research program is centered on studying fundamental mechanisms of aging and developing therapeutics to target them. Dr. Niedernhofer’s research involves implementing a murine model of a human progeroid syndrome caused by a defect in DNA repair, which provides insights into the impact of DNA damage on DNA structure, cell function, and organism health. She contributed to the discovery of a new class of drugs called senolytics. Her career includes serving on study sections for NCI, NIEHS, and NIA, and she has been recognized with awards for research in aging, cancer, and environmental health science.
Research topics
- Biology
- Cell biology
- Medicine
- Cancer research
- Genetics
Recent grants
NIH · $146k · 2008
NIH · $461k · 2008
Administrative Supplement to: Cell Autonomous and Non-Autonomous Mechanisms of Aging
NIH · $17.7M · 2019–2020
Immune cells as a driver of cell non-autonomous aging
NIH · $3.4M · 2019–2024
Immune cells as a driver of cell non-autonomous aging
NIH · $385k · 2018–2019
Frequent coauthors
- 243 shared
Paul D. Robbins
University of Minnesota
- 102 shared
Matthew J. Yousefzadeh
Institute on Aging
- 71 shared
Andria R. Robinson
Università Cattolica del Sacro Cuore
- 50 shared
Luise Angelini
University of Minnesota System
- 49 shared
Sara J. McGowan
University of Minnesota System
- 49 shared
James L. Kirkland
Mayo Clinic
- 45 shared
Erin A. Wade
The Ohio State University Wexner Medical Center
- 38 shared
Kenneth H. Kraemer
Labs
Niedernhofer LabPI
Education
- 2003
Post-doc, Genetics
Erasmus University Medical Center
- 1998
M.D.
Vanderbilt University School of Medicine
- 1996
Ph.D., Biochemistry
Vanderbilt University School of Medicine
- 1990
M.S., Physiology Medicine
Georgetown University School of Medicine
- 1985
B.S., Chemistry
Duke University
Awards & honors
- Dr. James E. Rubin Medical Memorial Award
- Graduating Medical Student Research Award
- Veneziale-Steer Award
- Dr. Marvin and Hadassah Bacaner Research Awards
- Schmidt Steer Award
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