Laura M. Wingler

About

Laura M. Wingler, Ph.D., is the Principal Investigator and an Assistant Professor of Pharmacology and Cancer Biology at Duke University. Her research focuses on pharmacology and cancer biology, as indicated by her role within the Duke University research team. She leads the Wingler Lab, which is dedicated to advancing understanding in these fields. Dr. Wingler is actively involved in mentoring graduate students and building her research team, including recruiting new members and postdoctoral researchers. Her work contributes to the broader scientific community through her leadership in pharmacology and cancer biology research at Duke University.

Research topics

• Chemistry
• Biology
• Biochemistry
• Cell biology
• Biophysics
• Computational biology
• Immunology
• Biotechnology
• Pharmacology
• Genetics

Selected publications

• Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

  Nature · 2020 · 364 citations

  PublisherOA PDFDOI

• Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

  Science · 2020-02-21 · 246 citations

  articleOpen access1st authorCorresponding

  Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signaling arises for the angiotensin II type 1 receptor that couples to two signaling partners (G proteins and arrestins). Suomivuori et al. used large-scale atomistic simulations to show that coupling to the two pathways is through two distinct GPCR conformat…

  PublisherOA PDFDOI

• Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

  Science · 2020-02-20 · 240 citations

  articleOpen access

  Biased signaling, in which different ligands that bind to the same G protein-coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of safer and more effective drugs. Its structural mechanism remains unclear, however, hampering efforts to design drugs with desired signaling profiles. Here, we use extensive atomic-level molecular dynamics simulations to determine how arrestin bias and G protein bias arise at the angiotensin II type 1 receptor. The…

  PublisherOA PDFDOI

• Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

  Trends in Cell Biology · 2020-07-02 · 228 citations

  reviewOpen access1st authorCorresponding
  PublisherOA PDFDOI

• Rapid generation of potent antibodies by autonomous hypermutation in yeast

  Nature Chemical Biology · 2021 · 129 citations

  PublisherOA PDFDOI

Frequent coauthors

• Robert J. Lefkowitz

  192 shared

• Dean P. Staus

  Duke Medical Center

  177 shared

• Seungkirl Ahn

  Duke University Hospital

  87 shared

• Ryan T. Strachan

  57 shared

• Brian K. Kobilka

  Stanford University

  55 shared

• Els Pardon

  Vrije Universiteit Brussel

  52 shared

• Jan Steyaert

  Vrije Universiteit Brussel

  52 shared

• Søren G. F. Rasmussen

  University of Copenhagen

  49 shared

Labs

• The Wingler Lab at Duke UniversityPI

Education

• B.S., Biochemistry

  North Carolina State University

• B.S., Chemistry

  North Carolina State University

• Ph.D., Chemistry

  Columbia University

Similar researchers at Duke University

• Christopher Bang Newgardh-175
• Donald Patrick McDonnellh-119
• Cynthia Moreton Kuhnh-110