Kristi S. Anseth

About

Kristi S. Anseth is a professor at the University of Colorado Boulder, where she is part of the Department of Chemical & Biological Engineering and the BioFrontiers Institute. Her research group specializes in the development of innovative biomaterials for engineered cell culture and tissue regeneration. Her primary focus is on decoding cell-material interactions and developing systems and techniques to investigate these processes. She influences cellular activity across timescales using engineering concepts and modeling, with targets ranging from molecular to macroscopic. Her work aims to modulate responses such as proliferation, differentiation, and extracellular matrix deposition by designing well-defined biomaterial niches with programmed mechanics and bioactivity. Her investigations include tailored cell carriers for therapeutic applications, hydrogel-based super-resolution microscopy, and models of homeostasis and pathology. She is actively involved in advancing the understanding of how biomaterials can be used to influence cellular behavior and tissue regeneration.

Research topics

• Cell biology
• Biology
• Computer Science
• Medicine
• Chemistry
• Pathology
• Genetics
• Biochemistry
• Nanotechnology
• Artificial Intelligence

Selected publications

• Tissue geometry drives deterministic organoid patterning

  Science · 2022 · 478 citations

  Epithelial organoids are stem cell–derived tissues that approximate aspects of real organs, and thus they have potential as powerful tools in basic and translational research. By definition, they self-organize, but the structures formed are often heterogeneous and irreproducible, which limits their use in the lab and clinic. We describe methodologies for spatially and temporally controlling organoid formation, thereby rendering a stochastic process more deterministic. Bioengineered stem cell mic…

  DOI

• Photoclick Chemistry: A Bright Idea

  Chemical Reviews · 2021 · 275 citations

  At its basic conceptualization, photoclick chemistry embodies a collection of click reactions that are performed via the application of light. The emergence of this concept has had diverse impact over a broad range of chemical and biological research due to the spatiotemporal control, high selectivity, and excellent product yields afforded by the combination of light and click chemistry. While the reactions designated as "photoclick" have many important features in common, each has its own parti…

  DOI

• Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

  Progress in Materials Science · 2020 · 253 citations

  Senior authorCorresponding
  DOI

• Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts

  Nature Biomedical Engineering · 2021 · 161 citations

  Senior authorCorresponding
  DOI

• Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells

  Arteriosclerosis Thrombosis and Vascular Biology · 2020 · 87 citations

  Senior authorCorresponding

  OBJECTIVE: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead to calcification of valve tissue. Inflammation is a hallmark of aortic valve stenosis, so we aimed to determine proinflammatory cytokines secreted from M1 macrophages that give rise to a transient VIC phenotype that leads to calcification of valve tissue. Approach and Results: We…

  DOI

Recent grants

• NIH Grant R55AR044375

  NIH · $100k · 1998

• Spatiotemporal Regulated Click Hydrogels for 3D Cell Culture

  NSF · $420k · 2010–2013

• RECODE: Materials-directed differentiation of intestinal organoids of uniform size and shape

  NSF · $1.5M · 2021–2024

Frequent coauthors

• Christopher N. Bowman

  University of Colorado Boulder

  235 shared

• Thomas P. Russell

  Lawrence Berkeley National Laboratory

  72 shared

• K. Kitazawa

  72 shared

• Tim Miller

  72 shared

• Bruce E. Kirkpatrick

  University of Colorado Boulder

  65 shared

• Leslie A. Leinwand

  University of Colorado Boulder

  54 shared

• Mark W. Tibbitt

  ETH Zurich

  54 shared

• Peter D. Mariner

  University of Colorado Boulder

  52 shared

Education

• Ph.D., Biomaterials and Tissue Engineering

  University of California, San Diego

  1996

• M.S., Biomaterials and Tissue Engineering

  University of California, San Diego

  1993

• B.S., Chemical Engineering

  University of California, San Diego

  1991

Similar researchers at University of Colorado Boulder

• Thomas R. Cechh-156
• Karolin Lugerh-89