Kevin P. Murphy

About

Kevin P. Murphy is a Professor in the Department of History at the University of Minnesota. His academic role involves teaching and research within the department, which is committed to providing students with an understanding of the past through diverse and interdisciplinary research interests. As a faculty member, he contributes to the department's mission of fostering appreciation and knowledge of history, supporting graduate students, and engaging in scholarly activities.

Research topics

• Medicine
• Internal medicine
• Biochemistry
• Chemistry
• Biology
• Immunology
• Endocrinology
• Cancer research

Selected publications

• Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

  Cardiovascular Research · 2021 · 37 citations

  1st authorCorresponding

  AIMS: Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous medium-/long-chain fatty acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in the heart is unclear. Given its putative beneficial role, we hypothesized that Ffar4 would protect the heart from pathologic stress. METHODS AND RESULTS: In mice lacking Ffar4 (Ffar4KO), we found that Ffar4 is required for an adaptive response to pressure overload induced by transverse aortic c…

  DOI

• FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome

  Journal of Lipid Research · 2023-04-17 · 16 citations

  articleOpen accessCorresponding

  Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome, but a predominant subset of HFpEF patients has metabolic syndrome (MetS). Mechanistically, systemic, nonresolving inflammation associated with MetS might drive HFpEF remodeling. Free fatty acid receptor 4 (Ffar4) is a GPCR for long-chain fatty acids that attenuates metabolic dysfunction and resolves inflammation. Therefore, we hypothesized that Ffar4 would attenuate remodeling in HFpEF secondary to MetS (HFpEF…

  PublisherOA PDFDOI

• Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

  Physiology · 2022-08-09 · 8 citations

  reviewOpen access

  A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation o…

  PublisherOA PDFDOI

• Comment on “Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice”

  The Journal of Immunology · 2022-10-01 · 2 citations

  letterOpen access

  FIGURE 2. Characterization of SC-390752 Ab in WT and FFAR4-KO mice. (A) Western blot of fractionated forebrain tissue lysates from WT and FFAR4-KO mice, stained with anti-FFAR4 (SC-390752) and anti-actin. Arrowheads indicate the location

  PublisherOA PDFDOI

• The interplay between sex, ApoE, and insomnia in Alzheimer's disease pathogenesis

  Alzheimer s & Dementia · 2025-12-01

  articleOpen access

  BACKGROUND: This work aims to elucidate the mechanisms underlying insomnia-induced Alzheimer's disease (AD) in a sex- and ApoE genotype-dependent manner to predict treatment responsiveness. Sex-based differences contribute to AD, with a higher prevalence among females. Additionally, there are known associations between ApoE genotype and sex in AD prognosis. Furthermore, sleep disorders are a risk factor for AD development and are more common in females than males. This work demonstrates pathway…

  PublisherOA PDFDOI

Frequent coauthors

• Thomas S. Griffith

  Twin Cities Orthopedics

  39 shared

• Alan L. Epstein

  28 shared

• John R. Ohlfest

  28 shared

• Jami R. Erickson

  University of Minnesota System

  26 shared

• Melissa G. Lechner

  University of California, Los Angeles

  26 shared

• Jessica Bedi

  26 shared

• Stacy A. Decker

  25 shared

• Flavia E. Popescu

  25 shared

Education

• Ph.D., Molecular, Cellular, Developmental Biology, and Genetics

  University of Minnesota

  2012

• B.S., Biochemistry, Microbiology

  University of Iowa

  2005

Awards & honors

• MidAmerica American Studies Association: Elizabeth Kolmer Aw…
• Award for Outstanding Contributions to Postbaccalaureate, Gr…
• Lambda Literary Award Finalist (LGBT Studies Category) for P…
• Social Science Research Council Post-Doctoral Fellowship in…
• Andrew P. Mellon Post-doctoral Fellowship, Center for the Hu…

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