Kenneth Kim

About

Kenneth Kim is an instructor of clinical physical therapy in the USC Division of Biokinesiology and Physical Therapy. He practices at USC Physical Therapy—University Park Campus, a faculty practice of the division, and specializes in treating all types of orthopedic and sports injuries. Dr. Kim is a Board-Certified Orthopedic Clinical Specialist and a member of the Orthopedic Section and Sports Section of the American Physical Therapy Association. He has been serving as a full-time instructor of clinical physical therapy at USC since 2013. In addition to his teaching role, he is a member of the USC Doctor of Physical Therapy Program’s admissions committee and serves as a course instructor and director for foundational courses focusing on therapeutic exercise during the first year of the DPT curriculum. Dr. Kim also volunteers as a faculty instructor for extracurricular groups that review didactic materials and apply them through live patient case examinations. He is actively involved in mentoring and teaching in post-professional education and continuing education courses, including serving as a primary mentor for USC orthopedic and sports residencies. Furthermore, he instructs in the Division’s Orthopedic Spine Seminar Series, which aims to enhance proficiency in physical therapy examination, evaluation, and intervention of musculoskeletal conditions, integrating concepts of manual therapy, movement science, and pain science.

Research topics

• Immunology
• Biology
• Intensive care medicine
• Pharmacology
• Biotechnology
• Medicine
• Internal medicine
• Chemistry
• Anesthesia

Selected publications

• In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives

  Advanced Drug Delivery Reviews · 2021 · 71 citations

  Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side effects, making it the preferred means of drug delivery for the treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease or cystic fibrosis. In addition, the high alveolar surface area, relatively low enzymatic activity and rich blood supply of the distal airspaces offer a promising pathway to the systemic circulation. This is particularly advantageous when a rapid onset of pharm…

  PublisherDOI

• Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells

  International Journal of Molecular Sciences · 2019-10-23 · 31 citations

  articleOpen access

  Background: Polystyrene nanoparticles (PNP) are taken up by primary rat alveolar epithelial cell monolayers (RAECM) in a time-, dose-, and size-dependent manner without involving endocytosis. Internalized PNP in RAECM activate autophagy, are delivered to lysosomes, and undergo [Ca2+]-dependent exocytosis. In this study, we explored nanoparticle (NP) interactions with A549 cells. Methods: After exposure to PNP or ambient pollution particles (PM0.2), live single A549 cells were studied using confo…

  PublisherOA PDFDOI

• Biokinetic modeling of nanoparticle interactions with lung alveolar epithelial cells: uptake, intracellular processing, and egress

  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2020-10-21 · 7 citations

  articleOpen access

  Studies on health effects of engineered nanomaterials (ENMs) in the lung have provided information on ENM toxicity and translocation across airway and alveolar epithelial barriers. Various inhaled ENMs (e.g., gold and iridium nanoparticles) have been reported to partially cross the air-blood barrier in the lung, enter the vasculature, and distribute in several end organs, including the heart, liver, spleen, and kidney. Using an in vitro primary rat alveolar epithelial cell (AEC) monolayer model,…

  PublisherOA PDFDOI

• Characteristics of Passive Solute Transport across Primary Rat Alveolar Epithelial Cell Monolayers

  Membranes · 2021-04-30 · 5 citations

  articleOpen access

  Primary rat alveolar epithelial cell monolayers (RAECM) were grown without (type I cell-like phenotype, RAECM-I) or with (type II cell-like phenotype, RAECM-II) keratinocyte growth factor to assess passive transport of 11 hydrophilic solutes. We estimated apparent permeability (Papp) in the absence/presence of calcium chelator EGTA to determine the effects of perturbing tight junctions on “equivalent” pores. Papp across RAECM-I and -II in the absence of EGTA are similar and decrease as solute si…

  PublisherOA PDFDOI

• Kinetics of autophagic activity in nanoparticle-exposed lung adenocarcinoma (A549) cells

  Autophagy Reports · 2023-03-15 · 3 citations

  articleOpen access

  Autophagy, a homeostatic mechanism, is crucial in maintaining normal cellular function. Although dysregulation of autophagic processes is recognized in certain diseases, it is unknown how maintenance of cellular homeostasis might be affected by the kinetics of autophagic activity in response to various stimuli. In this study, we assessed those kinetics in lung adenocarcinoma (A549) cells in response to exposure to nanoparticles (NP) and/or Rapamycin. Since NP are known to induce autophagy, we wi…

  PublisherDOI

Recent grants

• NIH Grant R01HL038658

  NIH · $3.0M · 2006

Frequent coauthors

• Edward D. Crandall

  Rogers (United States)

  233 shared

• Zea Borok

  University of California, San Diego

  138 shared

• Arnold Sipos

  University of Southern California

  86 shared

• Vincent H.L. Lee

  67 shared

• Yong Ho Kim

  42 shared

• Young–Jin Son

  Sunchon National University

  33 shared

• Carsten Ehrhardt

  Trinity College Dublin

  32 shared

• Per Flodby

  Hastings Center

  30 shared

Labs

• Health Equity LabPI

Education

• Other, Physical Therapy

  University of Southern California

• Other, Physical Therapy

  University of Southern California

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• Lucinda Bakerh-54
• Eileen Johnsonh-45