Kee-Hyun Kim

About

Kee-Hyun Kim is a professor of the practice in the Department of Music at Harvard University. A native of Seoul, Korea, he is a cellist praised for his assertive style and vital musical spirit. Kim has participated in numerous prestigious festivals, including the Mostly Mozart Festival, the Kronberg Cello Masterclasses and Festival, the World Cello Congress III, the Aspen Music Festival, and Music Academy of the West. He has won top prizes in major competitions in Korea, such as the Ehwa, Sae-gae, and Korean Newspaper Competitions, and placed second in the Pusan National Competition. His awards include the Landgraf-von-Hessen Prize at the 1999 Kronberg Cello Masterclasses and second prize in the Hudson Valley String competition in 2002. As a founding member of the Parker Quartet, Kim has received notable distinctions including 1st prize at the Bordeaux String Quartet competition, the Cleveland Quartet Award, and a Grammy Award for Best Chamber Music Performance in 2010. Kim began his musical education early, attending the Juilliard pre-college in 1992, and studying at the Korean National University of the Arts, the New England Conservatory, and the Walnut Hill School. He holds a B.M. and two M.M. degrees from the New England Conservatory. Since fall 2014, he has been teaching at Harvard University’s music department alongside the members of the Parker Quartet. When not performing, Kim is interested in maintaining physical and mental health, exploring international cuisine…

Research topics

• Biology
• Cell biology
• Neuroscience
• Internal medicine
• Psychology
• Pathology
• Chemistry
• Computational biology
• Medicine

Selected publications

• Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

  New England Journal of Medicine · 2020 · 506 citations

  Senior authorCorresponding

  We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with idiopathic Parkinson's disease. The patient-specific progenitor cells were produced under Good Manufacturing Practice conditions and characterized as having the phenotypic properties of substantia nigra pars compacta neurons; testing in a humanized mouse model (involving peripheral-blood mononuclear cells) indicate…

  DOI

• Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease

  Nature · 2023-07-12 · 115 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

  Nature Chemical Biology · 2020 · 88 citations

  Senior authorCorresponding
  DOI

• SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

  Cell Reports · 2021-12-01 · 62 citations

  articleOpen accessSenior authorCorresponding

  During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the induction of pluripotency, but its molecular mechanisms remain poorly defined. Notably, SIRT2 is consistently downregulated during the reprogramming process and regulates glycolytic switch. Here, we report that downregulation of SIRT2 increases acetylation of…

  PublisherDOI

• An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models

  Nature Communications · 2023-07-18 · 44 citations

  articleOpen accessSenior author

  The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for Parkinson's disease (PD). We previously identified three Nurr1 agonists (amodiaquine, chloroquine and glafenine) that share an identical chemical scaffold, 4-amino-7-chloroquinoline (4A7C), suggesting a structure-activity relationship. Herein we report a systematic medicinal chemistry search in which over 570 4A7C-derivatives were generated…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01DC006501

  NIH · $1.3M · 2009

• NIH Grant R21AG046599

  NIH · $435k · 2017

• NIH Grant R21MH087903

  NIH · $627k · 2011

Frequent coauthors

• Pierre Leblanc

  Massachusetts General Hospital

  80 shared

• Chun‐Hyung Kim

  78 shared

• Sangmi Chung

  Rutgers, The State University of New Jersey

  66 shared

• Young Cha

  Harvard University

  60 shared

• Bin Song

  Harvard University

  57 shared

• Jeffrey S. Schweitzer

  Massachusetts General Hospital

  43 shared

• Ole Isacson

  Harvard University

  35 shared

• Woori Kim

  Ulsan College

  35 shared

Awards & honors

• Landgraf-von-Hessen Prize at the 1999 Kronberg Cello Masterc…
• second prize in the Hudson Valley String competition (2002)
• 1st prize at the Bordeaux String Quartet competition
• Cleveland Quartet Award
• 2010 Grammy Award for "Best Chamber Music Performance"

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