Katie Anderson
· Professor of Supply Chain & OperationsVerifiedUniversity of Minnesota · Supply Chain and Operations Management
Active 1981–2025
About
Ravi Bapna is the Curtis L. Carlson Chair Professor in Business Analytics and Information Systems and serves as the Academic Director of the Carlson Analytics Lab at the Carlson School of Management. He is closely affiliated with the Carlson School's MS in Business Analytics program and the Carlson Analytics Lab, where graduate students study a broad range of data analysis techniques and apply them to real business problems. These students are skilled in exploratory data visualization, predictive analytics techniques, programming, data engineering, machine learning methods, and more, emerging as data science professionals. Partner organizations have the opportunity to work with these talented students while supporting the educational mission of the programs.
Research topics
- Medicine
- Biology
- Genetics
- Internal medicine
- Psychology
- Psychiatry
- Bioinformatics
- Gynecology
- Computational biology
- Oncology
- Obstetrics
- Medical emergency
Selected publications
Human Reproduction · 2025-06-01
articleOpen accessAbstract Study question In couples with unexplained infertility, are four cycles of IUI-OS comparable to one complete cycle of IVF for the outcome of live birth? Summary answer IUI-OS was inferior to IVF. Approximately one in two couples had a live birth with IVF compared to one in three couples with IUI-OS. What is known already IUI-OS is widely used as a low-cost, less invasive alternative to IVF for couples with unexplained infertility. It is recommended as first-line treatment in the 2023 ESHRE guideline for unexplained infertility. A 2023 Cochrane review found little or no difference in the live birth rate (LBR) between 2-3 cycles of IUI-OS with gonadotrophins and one IVF cycle for treatment naïve women (OR 1.19, 95% CI 0.87 to 1.61; 3 RCTs; low-quality evidence). Only one published RCT has compared IVF with IUI-OS using clomiphene citrate (two cycles) (OR 2.51, 95% CI 0.96 to 6.55; 1 RCT; 103 women; low-quality evidence). Study design, size, duration A multicentre, open-label, non-inferiority randomised controlled trial. Participants were randomised (August 2019 - March 2024) 1:1 to IUI-OS or IVF using a web-based data system with a variable block design. COVID-19 impacted the trial, prompting modifications in August 2021, in line with published guidance, including increasing the sample size from 580 to 730, excluding 151 participants randomised during affected periods from the primary outcome analysis, and extending the primary outcome collection window by one month. Participants/materials, setting, methods Six New Zealand fertility clinics recruited couples with unexplained infertility to IUI-OS (up to four cycles with oral stimulation) or IVF (including all fresh and frozen embryos from one cycle). A non-inferiority analysis was performed using regression standardisation to calculate a risk difference adjusted for the stratification variables (female age and centre), with a confidence interval obtained by bootstrapping. In a non-inferiority context, a 90% CI corresponds to a test at a 5% significance level. Main results and the role of chance 737 couples were randomised: 372 to IUI-OS and 365 to IVF. Two patients withdrew. Mean female age was 34.3 years (SD 3.3), median duration of infertility was 63 months (IQR 55-75), 19% of participants had a previous birth, 7% previous IVF, and 18% previous IUI-OS. IUI-OS was not non-inferior, and was substantially inferior, to IVF. There were 89/288 (31%) live births in the IUI-OS arm compared to 164/298 (55%) in the IVF arm; adjusted risk difference (90% CI) -23 (-30 to -18) percentage points (this includes 13 ongoing pregnancies expected to lead to live births). There was no evidence that the effect varied by age (p = 0.79) or by centre (p = 0.61). When all 737 participants were included in the analysis, the CLBR remained similar – 113/365 (31%) live births in the IUI-OS arm compared to 203/372 (56%) in the IVF arm, adjusted risk difference (90% CI) -23 (-26 to -13) percentage points. There were four twin births in the IUI-OS arm and three in the IVF arm. Eight ectopic pregnancies occurred in the IUI-OS arm and two in the IVF arm. The IVF arm had nine treatment-related serious adverse events (SAEs) requiring hospitalisation, while the IUI-OS arm had one (OHSS from off-protocol IVF). Limitations, reasons for caution The inclusion criteria were broader than the ESHRE definition of unexplained infertility and included participants with mild male factor and rASRM stage I/ II endometriosis, reflecting the inclusion criteria of previous clinical trials. The live birth rate for IVF was higher than anticipated based on previous trials and national data. Wider implications of the findings Although IVF appears superior to IUI-OS, IUI-OS provides respectable LBRs (31%), and patients deciding between IUI-OS and IVF may consider other factors (cost, level of invasiveness, potential for frozen embryos). Cost-effectiveness analysis and the effectiveness of IUI-OS followed by IVF will be reported in subsequent publications. Trial registration number Yes
Pooled analysis of active cigarette smoking and invasive breast cancer risk in 14 cohort studies
UNC Libraries · 2024-08-01
articleOpen accessBackground: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status. Methods: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases). Cox proportional hazard regression models were used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Smoking duration before first birth was positively associated with risk ( P -value for trend = 2 × 10 -7 ) with the highest HR for initiation >10 years before first birth (HR = 1.18, CI 1.12-1.24). Effect modification by current alcohol consumption was evident for the association with smoking duration before first birth ( P -value=2×10 -4 ); compared with never-smoking non-drinkers, initiation >10 years before first birth was associated with risk in every category of alcohol intake, including non-drinkers (HR = 1.15, CI 1.04-1.28) and those who consumed at least three drinks per day (1.85, 1.55-2.21). Associations with smoking before first birth were limited to risk of ER+ breast cancer ( P -value for homogeneity=3×10 -3 ). Other smoking timing and duration characteristics were associated with risk even after controlling for alcohol, but were not associated with risk in non-drinkers. Effect modification by menopause was not evident. Conclusions: Smoking, particularly if initiated before first birth, was modestly associated with ER+ breast cancer risk that was not confounded by amount of adult alcohol intake. Possible links with breast cancer provide additional motivation for young women to not initiate smoking.
2023-03-31
preprintOpen access<div>Abstract<p><b>Background:</b> Host immune response may predict the course of colorectal cancer. We examined the survival of 468 colorectal cancer patients associated with two tumor-infiltrating immune biomarkers, the number of cytotoxic T lymphocytes (CTLs), and the activated CTLs, as reflected by the number of cells expressing granzyme B (GZMB) in the prospective Iowa Women's Health Study.</p><p><b>Methods:</b> Using paraffin-embedded tissue samples, we constructed and immunostained tumor microarrays with CD8 (for CTL) and GZMB antibodies. We scored CTL and GZMB densities in tumor epithelial and stromal tissues and also created a composite score for each biomarker (sum of the scores across tissue compartments). Cox regression estimated the HR and 95% confidence intervals (CI) for all-cause and colorectal cancer–specific death associated with each composite score.</p><p><b>Results:</b> CTL and GZMB composite scores were positively correlated (<i>r</i> = 0.65) and each biomarker was inversely correlated with stage at diagnosis. Both composite scores were higher in proximal colon tumors and tumors characterized by MSI-high, CIMP-high, or <i>BRAF</i> mutation status. HRs (95% CI) were 0.53 (0.38–0.75; <i>P</i><sub>trend</sub> = 0.0004) and 0.66 (0.51–0.86; <i>P</i><sub>trend</sub> = 0.002) for all-cause death, respectively, and 0.30 (0.18–0.51; <i>P</i><sub>trend</sub> < 0.0001) and 0.41 (0.27–0.63; <i>P</i><sub>trend</sub> < 0.0001) for colorectal cancer–related death, respectively. Including CTL and GZMB scores simultaneously in the model significantly improved the predictive performance of the models for all-cause and colorectal cancer–related death.</p><p><b>Conclusions:</b> Higher tumor infiltration with CTL and GZMB cells is associated with improved all-cause and cancer-specific survival of colorectal cancer patients.</p><p><b>Impact:</b> Both the number of CTLs and GZMB appear to be useful prognostic factors in colorectal cancer, irrespective of stage. <i>Cancer Epidemiol Biomarkers Prev; 26(4); 622–31. ©2016 AACR</i>.</p></div>
2023-03-31
preprintOpen access<p>Supplementary Table 1. Classification of myeloid and lymphoid malignancies using International Classification of Diseases for Oncology, Third Edition (ICD-O-3) morphology codes.</p>
2023-03-31
preprintOpen access<p>Supplementary Table 1. Classification of myeloid and lymphoid malignancies using International Classification of Diseases for Oncology, Third Edition (ICD-O-3) morphology codes.</p>
Improved Clinic Flow and Satisfaction After Lean Implementation in a Pediatric Ophthalmology Clinic
Journal of Pediatric Ophthalmology & Strabismus · 2023-04-24 · 1 citations
articleSenior authorPURPOSE: To report outcomes using Lean concepts (FlowOne Lean Consulting, LLC) and implemented changes in a single academic pediatric ophthalmology practice. METHODS: Lean principles such as patient flow, wasted movement, and non-value added visit time were taught to clinic staff. Spaghetti maps to document patient and staff movement during examinations, patient simulation, and clinic flow exercises were performed prior to implementing clinic changes. Clinic changes included maximizing easily reachable equipment and standardizing equipment in each examination room, physician-controlled doorbells to notify staff for help, and implementing a visual real-time electronic board of patients throughout the entirety of their examination. Patient surveys before and after Lean and staff feedback were obtained. RESULTS: Four years of data were collected of patient examination visits after Lean principles were introduced. Prior to Lean implementation, mean pediatric ophthalmology clinic visit times were 120 minutes. Within 3 months of Lean clinic changes, mean visit times reduced to 75 minutes. Four years later, this was sustained at 69 minutes. Clinic templates were modified and increased by 17%. Patient satisfaction surveys before and after demonstrated improved scores from 6.5 to 9.0. Patient survey comments included satisfaction with shorter patient examination visits, less shuffling between examination rooms, less non-value added time, and perception of happier clinic staff. Staff survey comments included receiving fewer parent complaints, feeling less disorganized, being able to troubleshoot in real time, and leaving at an earlier time at the end of the clinic day. CONCLUSIONS: .
Cancer Research · 2023-04-04
articleAbstract Pancreatic cancer is the third leading cause of cancer-related death in the U.S. and has a 5-year relative survival rate of only 11.5%. The etiology of pancreatic cancer is not well understood, with cigarette smoking, type 2 diabetes, and chronic pancreatitis as the only well-established risk factors. Therefore, it is critical to identify modifiable risk factors for primary prevention. Persistent oxidative stress and resultant oxidative damage can lead to accumulated mutations in oncogenes and tumor suppressor genes and subsequent carcinogenesis of the pancreas. Carotenoids are abundant in fruits and vegetables, while tocopherols are rich in oilseeds and nuts. Both carotenoids and tocopherols have antioxidant functions. Thus, it is possible that high intake of these bioactive compounds can reduce risk of pancreatic cancer. The present study sought to investigate this question in a case-control study conducted during 1994-1998 in Minnesota. Cases (n=150), aged 20 years or older, were ascertained from all hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic; from the latter, only cases residing in the Upper Midwest of the US were recruited. Controls (n=459) were randomly selected from the general population and frequency matched to cases by age (within 5 years) and sex. Intake of carotenoids and tocopherols from diet and supplements was estimated from a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression. As lutein and zeaxanthin are isomers that have identical chemical formulas, they are combined into a single variable in the analysis. All dietary variables were adjusted for energy intake with the residual method prior to data analysis. After adjustment for age, sex, race, education, physical activity, cigarette smoking, and alcohol consumption, intake of lutein and zeaxanthin was associated with a significantly reduced risk of pancreatic cancer [OR (95% CI) for quartile 4 (median: 4972 µg/day) vs. quartile 1 (median: 976 µg/day): 0.39 (0.19-0.79); p-trend: 0.06]. This inverse association became slightly weaker but remained statistically significant after additional adjustment for intake of energy, fat, and fiber. No significant associations were observed for intake of α-carotene, β-carotene, lycopene, β-cryptoxanthin, α-tocopherol, β-tocopherol, and δ-tocopherol, although a higher intake of all these nutrients except α-tocopherol and δ-tocopherol tended to confer a lower risk. Our study shows that there is a significant, beneficial effect of lutein and zeaxanthin intake on pancreatic cancer risk, although it may be a chance finding due to multiple comparisons. More epidemiologic studies are warranted to further elucidate the roles of carotenoids and tocopherols in the etiology and prevention of pancreatic cancer. Citation Format: Bronson Dokmanovich, Hao fan, Yunpeng Yu, Kristin Anderson, Jianjun Zhang. Carotenoid and tocopherol intake in relation to pancreatic cancer risk in a population-based case-control study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6447.
Emergency room presentations of people with anorexia nervosa
Journal of Eating Disorders · 2023 · 14 citations
- Psychiatry
- Medicine
- Psychology
People with anorexia nervosa (AN) tend to shy away from engaging in typical primary care provider relationships in order to avoid detection. Therefore, they may seek care for their medical concerns through a local emergency department (ED). Inherently, AN is associated with a litany of medical complications, which become more prevalent as the severity of their eating disorder increases. Notwithstanding the typical young age at the onset of AN, no body system is immune to these medical complications. Thus, ED providers may need to pursue a medical diagnosis in order to explain presenting symptoms in people with AN. In addition to the medical issues, AN is also a serious mental illness with high mortality rates, including deaths by suicide. Therefore, ED providers also need to be familiar with relevant mental health issues for these people.
2023-03-31
preprintOpen access<div>Abstract<p><b>Background:</b> Allergic diseases signify immune dysregulation attributable to underlying genetics and environmental exposures. Associations between various allergies and hematopoietic cancers have been observed, albeit inconsistently; however, few prospective studies have examined the risk, and even fewer among older adults.</p><p><b>Methods:</b> We examined risk of incident hematopoietic cancers in those reporting allergic diseases in a population-based cohort of 22,601 older women (Iowa Women's Health Study). Self-reported allergic status, including asthma, hay fever, eczema, and/or other allergies, was determined via questionnaire in 1997 (mean age, 72 years; range, 63–81 years). Incident cancers were ascertained by linkage with the Iowa Cancer Registry from 1997 to 2011. Cox proportional hazards regression was performed to estimate multivariate-adjusted HR and 95% confidence intervals (CI) for myeloid (<i>N</i> = 177) and lymphoid (<i>N</i> = 437) malignancies, respectively.</p><p><b>Results:</b> Allergic diseases were not associated with risk of myeloid (HR, 1.00; 95% CI, 0.72–1.37) or lymphoid (HR, 0.99; 95% CI, 0.81–1.22) malignancies overall, or for most allergic and malignant subtypes examined. Self-reported asthma was positively associated with development of myelodysplastic syndrome (MDS; HR, 2.00; 95% CI, 0.93–4.32). In addition, there was a 30% to 40% decrease in risk of both lymphoid and myeloid cancers in those reporting rural residences but no association in those reporting urban residences; the interaction between residence and allergy was statistically significant for lymphoid malignancies (<i>P</i><sub>interaction</sub> = 0.05).</p><p><b>Conclusions and Impact:</b> These results suggest that asthma may contribute to the pathogenesis of MDS, a finding consistent with the chronic antigen stimulation hypothesis. Susceptibility differences by location of residence are concordant with the hygiene hypothesis and merit additional exploration. <i>Cancer Epidemiol Biomarkers Prev; 23(9); 1903–12. ©2014 AACR</i>.</p></div>
2023-03-31
preprintOpen access<div>Abstract<p><b>Background:</b> Host immune response may predict the course of colorectal cancer. We examined the survival of 468 colorectal cancer patients associated with two tumor-infiltrating immune biomarkers, the number of cytotoxic T lymphocytes (CTLs), and the activated CTLs, as reflected by the number of cells expressing granzyme B (GZMB) in the prospective Iowa Women's Health Study.</p><p><b>Methods:</b> Using paraffin-embedded tissue samples, we constructed and immunostained tumor microarrays with CD8 (for CTL) and GZMB antibodies. We scored CTL and GZMB densities in tumor epithelial and stromal tissues and also created a composite score for each biomarker (sum of the scores across tissue compartments). Cox regression estimated the HR and 95% confidence intervals (CI) for all-cause and colorectal cancer–specific death associated with each composite score.</p><p><b>Results:</b> CTL and GZMB composite scores were positively correlated (<i>r</i> = 0.65) and each biomarker was inversely correlated with stage at diagnosis. Both composite scores were higher in proximal colon tumors and tumors characterized by MSI-high, CIMP-high, or <i>BRAF</i> mutation status. HRs (95% CI) were 0.53 (0.38–0.75; <i>P</i><sub>trend</sub> = 0.0004) and 0.66 (0.51–0.86; <i>P</i><sub>trend</sub> = 0.002) for all-cause death, respectively, and 0.30 (0.18–0.51; <i>P</i><sub>trend</sub> < 0.0001) and 0.41 (0.27–0.63; <i>P</i><sub>trend</sub> < 0.0001) for colorectal cancer–related death, respectively. Including CTL and GZMB scores simultaneously in the model significantly improved the predictive performance of the models for all-cause and colorectal cancer–related death.</p><p><b>Conclusions:</b> Higher tumor infiltration with CTL and GZMB cells is associated with improved all-cause and cancer-specific survival of colorectal cancer patients.</p><p><b>Impact:</b> Both the number of CTLs and GZMB appear to be useful prognostic factors in colorectal cancer, irrespective of stage. <i>Cancer Epidemiol Biomarkers Prev; 26(4); 622–31. ©2016 AACR</i>.</p></div>
Recent grants
NIH · $1.6M · 2015
NIH · $2.2M · 1999
Frequent coauthors
- 268 shared
James R. Cerhan
Mayo Clinic in Florida
- 195 shared
Robert A. Vierkant
- 190 shared
Paul J. Limburg
Exact Sciences (United States)
- 170 shared
Alice H. Wang
Anhui Medical University
- 144 shared
Charles F. Lynch
University of Iowa
- 140 shared
Aaron R. Folsom
University of Minnesota
- 140 shared
Stephen N. Thibodeau
- 139 shared
Lori S. Tillmans
Education
- 1991
MPH, School of Public Health
University of Minnesota Twin Cities
- 1984
PhD
University of Wisconsin Madison
- 1975
B.S
University of Wisconsin Madison
Awards & honors
- Jay Chiat and Effie awards for strategic excellence
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