About

Kathryn Murphy is associated with the College of Veterinary Medicine at NC State University, where she is involved in fostering student engagement and supporting the academic community. Her role includes overseeing student experience initiatives, promoting extracurricular opportunities, and enhancing the overall educational environment for veterinary students. She is dedicated to creating a caring, collaborative culture that emphasizes student achievement, well-being, and professional development. Murphy's work supports the college's mission to shape the future of veterinary medicine by nurturing a community of inquisitive, empathetic, and ethically driven students who are prepared to make a positive impact in their communities and the broader field of veterinary medicine.

Research topics

• Internal medicine
• Medicine
• Cardiology
• Intensive care medicine
• Surgery
• Radiology
• Immunology

Selected publications

• ChatGPT Applications in Heart Failure: Patient Education, Readability Enhancement, and Clinical Utility

  Journal of Cardiovascular Development and Disease · 2025-10-24

  articleOpen access

  Background: Heart failure (HF) affects over 64 million people globally, imposing substantial morbidity, mortality, and economic burdens. Despite advances in guideline-directed therapies, adherence remains suboptimal due to low health literacy and complex regimens. ChatGPT, an advanced large language model by OpenAI, offers conversational capabilities that could enhance HF education, management, and research. This systematic review synthesizes evidence on ChatGPT’s applications in HF, evaluating its accuracy in patient education and question-answering, enhancing readability, and clinical documentation/symptom extraction. Methods: Following PRISMA guidelines, we searched PubMed, Embase, and Cochrane up to July 2025 using the terms “ChatGPT” and “heart failure”. Inclusion: Studies on ChatGPT (3.5 or 4) in HF contexts, such as in education, readability and symptom extraction. Exclusion: Non-HF or non-ChatGPT AI. Data extraction covered design, objectives, methods, and outcomes. Thematic synthesis was applied. Results: From 59 records, 7 observational studies were included. Themes included patient education/question-answering (n = 5), readability enhancement (n = 2), and clinical documentation/symptom extraction (n = 1). Accuracy ranged 78–98%, with high reproducibility; readability improved to 6th–7th grade levels; and symptom extraction achieved up to 95% F1 score, outperforming traditional machine learning baselines. Conclusions: ChatGPT shows promise in HF care but requires further randomized validation for outcomes and bias mitigation.

  PublisherOA PDFDOI

• ChatGPT Applications in Heart Failure: Patient Education, Readability Enhancement, and Clinical Utility

  Preprints.org · 2025-10-16

  preprintOpen access

  Background: Heart failure (HF) affects over 64 million people globally, imposing substantial morbidity, mortality, and economic burdens. Despite advances in guideline-directed therapies, adherence remains suboptimal due to low health literacy and complex regimens. ChatGPT, an advanced large language model by OpenAI, offers conversational capabilities that could enhance HF education, management, and research. This systematic review synthesizes evidence on ChatGPT's applications in HF, evaluating its accuracy in patient education and question-answering, enhancing readability, and clinical documentation/symptom extraction. Methods: Following PRISMA guidelines, we searched PubMed, Embase, and Cochrane up to July 2025 using the terms "ChatGPT" and "heart failure." Inclusion: Studies on ChatGPT (3.5 or 4) in HF contexts, such as in education, readability and symptom extraction. Exclusion: Non-HF or non-ChatGPT AI. Data extraction covered design, objectives, methods, outcomes. Thematic synthesis applied. Results: From 59 records, 7 observational studies were included. Themes included: patient education/question-answering (n=5), readability enhancement (n=2), clinical documentation/symptom extraction (n=1). Accuracy ranged 78-98%, with high reproducibility; readability improved to 6th-7th grade levels; and symptom extraction achieved up to 95% F1 score, outperforming traditional machine learning baselines.Conclusions: ChatGPT shows promise in HF care but requires further randomized validation for outcomes and bias mitigation.

  PublisherOA PDFDOI

• MYOCARDITIS IN THE SHADOWS: A CASE OF STREPTOCOCCAL PHARYNGITIS ASSOCIATED MYOCARDITIS

  Journal of the American College of Cardiology · 2025-03-29 · 1 citations

  articleOpen accessSenior author
  PublisherDOI

• Cytology of the ear

  2024-09-13

  book-chapterSenior author

  The external ear functions as a conduit for sound to the middle ear and is also important for expression of behavior. The external ear is composed of the pinna (or auricle), the external auditory meatus (the entrance to the ear canal), and the cartilaginous ear canal. There is a small osseous component to the ear canal of the dog and cat, which is more developed in large animals such as horses and cattle. The external ear canal ends at the tympanic membrane (ear drum).

  PublisherDOI

• Cardiac Magnetic Resonance Imaging in Heart Transplant Recipients with Biopsy-Negative Graft Dysfunction

  ESC Heart Failure · 2024 · 4 citations

  • Medicine
  • Cardiology
  • Internal medicine

  AIMS: Graft dysfunction (GD) after heart transplantation (HTx) can develop without evidence of cell- or antibody-mediated rejection. Cardiac magnetic resonance imaging (CMR) has an evolving role in detecting rejection; however, its role in biopsy-negative GD has not been described. This study examines CMR findings, evaluates outcomes based on CMR results, and seeks to identify the possibility of rejection missed through endomyocardial biopsy by using CMR in HTx recipients with biopsy-negative GD. METHODS AND RESULTS: HTx recipients with GD [defined as a decrease in left ventricular ejection fraction (LVEF) by >5% and LVEF < 50%] in the absence of rejection by biopsy or allograft vasculopathy and who underwent CMR were included in the study. The primary outcome was a composite of all-cause mortality, re-transplantation, or persistent LVEF < 50%. Overall, 34 HTx recipients developed biopsy-negative GD and underwent CMR. Left ventricular late gadolinium enhancement (LGE) on CMR was observed in 16 patients with two distinct patterns: diffuse epicardial (n = 13) and patchy (n = 3) patterns. Patients with LGE developed GD later after HTx [4 (1.4-6.8) vs. 0.8 (0.3-1.2) years, P < 0.001], were more often symptomatic (88% vs. 56%, P = 0.06), and had greater haemodynamic derangement (pulmonary capillary wedge pressure: 19 ± 7 vs. 13 ± 3 mmHg, P = 0.002) as compared with those without LGE. No significant difference was observed in the primary composite outcome between patients with LGE and those without LGE (50% vs. 38% of patients with events, P = 0.515). During a median follow-up of 3.8 years, mean LVEF improved similarly in the LGE-negative (37-55%) and LGE-positive groups (32-55%) (P = 0.16). CONCLUSIONS: Biopsy-negative GD occurs with and without LGE when assessed by CMR, indicative of possible rejection/inflammation occurring only in a subset of patients. Irrespective of LGE, LVEF improvement occurs in most GD patients, suggesting that other neurohormonal or immunomodulatory mechanisms may also contribute to GD development.

  PublisherOA PDFDOI

• The Impact Of Years Since Transplant On The Clinical Course After SARS-CoV-2 Infection In Heart Transplant Recipients

  Journal of Cardiac Failure · 2023-04-01

  articleOpen access
  PublisherOA PDFDOI

• Implementing a community specialist team to support the delivery of integrated diabetes care: experiences in Ireland during the COVID-19 pandemic

  HRB Open Research · 2023-01-05 · 2 citations

  preprintOpen access

  <ns4:p> <ns4:bold>Background: </ns4:bold> While models of integrated care for people with chronic conditions have demonstrated promising results, there are still knowledge gaps about <ns4:italic>how</ns4:italic> these models are implemented in different contexts and which strategies may best support implementation. We aimed to evaluate the implementation of a multidisciplinary diabetes Community Specialist Team (CST) to support delivery of integrated type 2 diabetes care during COVID-19 in two health networks. </ns4:p> <ns4:p> <ns4:bold>Methods: </ns4:bold> A mixed methods approach was used. Quantitative data included administrative data on CST activity and caseload, and questionnaires with GPs, practice nurses (PN) and people with type 2 diabetes. Qualitative data were collected using semi-structured interviews and focus groups about the service from CST members, GPs, PNs and people with type 2 diabetes. We used the Consolidated Framework for Implementation Research framework to explain what influences implementation and to integrate different stakeholder perspectives. </ns4:p> <ns4:p> <ns4:bold>Results: </ns4:bold> Over a 6-month period (Dec 2020-May 2021), 516 patients were seen by podiatrists, 435 by dieticians, and 545 by CNS. Of patients who had their first CST appointment within the previous 6 months (n=29), 69% (n=20) waited less than 4 weeks to see the HCP. During initial implementation, CST members used virtual meetings to build ‘ <ns4:italic>rapport’</ns4:italic> with general practice staff, supporting ‘ <ns4:italic>upskilling’</ns4:italic> and referrals to the CST. Leadership from the local project team and change manager provided guidance on how to work as a team and ‘ <ns4:italic>iron out’</ns4:italic> issues. Where available, shared space enhanced networking between CST members and facilitated joint appointments. Lack of administrative support for the CST impacted on clinical time. </ns4:p> <ns4:p> <ns4:bold>Conclusions: </ns4:bold> This study illustrates how the CST benefited from shared space, enhanced networking, and leadership. When developing strategies to support implementation of integrated care, the need for administrative support, the practicalities of co-location to facilitate joint appointments, and relative advantages of different delivery models should be considered. </ns4:p>

  PublisherDOI

• Pathology in Practice

  Journal of the American Veterinary Medical Association · 2022-05-26

  articleOpen access

  In collaboration with the American College of Veterinary Pathologists.

  PublisherOA PDFDOI

• Long‐term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T‐cells, <scp>IL</scp>‐10 and <scp>TGF</scp>‐β, in dogs with atopic dermatitis

  Veterinary Dermatology · 2022 · 8 citations

  • Medicine
  • Immunology
  • Internal medicine

  BACKGROUND: Atopic dogs often are managed with allergen-specific immunotherapy (AIT) and concurrent dosages of ciclosporin (CSA) or oclacitinib to alleviate their clinical signs. Both drugs might affect proper tolerance induction by inhibiting regulatory T-cell (Treg) induction. HYPOTHESIS/OBJECTIVES: We evaluated Treg cell numbers and serum interleukin (IL)-10 and transforming growth factor-beta (TGF-β)1 levels in dogs diagnosed with atopic dermatitis (AD) and successfully treated with either CSA or oclacitinib for nine or more months. ANIMALS: We included 15 dogs receiving oclacitinib, 14 dogs treated with CSA, 15 healthy dogs, 13 dogs with untreated moderate-to-severe AD and 15 atopic dogs controlled with AIT. MATERIALS AND METHODS: Peripheral blood CD4+CD25+FOXP3+ T-cell percentages were determined using flow cytometry. Serum concentrations of IL-10 and TGF-β1 were measured by enzyme-linked immunosorbent assay. RESULTS: The percentage of Treg cells in the CSA group was significantly lower in comparison with the healthy group (p = 0.0003), the nontreated AD group (p = 0.0056) or the AIT group (p = 0.0186). There was no significant difference in Treg cell percentages between the CSA and oclacitinib groups, nor between the oclacitinib and the healthy, nontreated AD or AIT-treated dogs. No significant differences were detected in IL-10 and TGF-β1 serum concentrations between the five groups. CONCLUSIONS AND CLINICAL RELEVANCE: Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. Functionality and cytokine production may be more important than the number of Treg cells. Further studies evaluating the treatment outcome of dogs receiving AIT and concurrent drugs are needed to show clinical relevance.

  PublisherDOI

• Eculizumab for Treatment of Biopsy Negative Rejection in Heart Transplantation

  The Journal of Heart and Lung Transplantation · 2021-03-20

  articleOpen access1st authorCorresponding
  PublisherDOI

Frequent coauthors

• Joe Moran

  University College Cork

  12 shared

• Colin Bradley

  12 shared

• Sheena Mc Hugh

  University College Cork

  12 shared

• Ivan J. Perry

  University College Cork

  12 shared

• Diarmuid Quinlan

  University College Cork

  11 shared

• Gabrielle O’Keeffe

  Health Service Executive

  9 shared

• Joseph Alade

  9 shared

• Ciaran Coughlan

  Optrace (Ireland)

  9 shared

Labs

• CVM: Focus AreaPI