Karsten Suhre

About

Karsten Suhre, Ph.D., is a Professor of Physiology and Biophysics and the Director of the Bioinformatics Core at Weill Cornell Medicine-Qatar. He joined the Department of Physiology and Biophysics at Weill Cornell Medicine in March 2011. His research interests are at the intersection of metabolomics and genomics and their role in human health. Since 2006, he has focused on how genetic variation in human metabolism interacts with environmental challenges and lifestyle factors in the development of complex diseases, especially diabetes, cancer, heart, and kidney diseases. His work has demonstrated that understanding the genetic basis of metabolic individuality in humans can generate new hypotheses for biomedical and pharmaceutical research and inform individualized therapy. Suhre has contributed to setting up and supporting industry-level metabolomics and proteomics facilities in Qatar, conducting clinical studies with metabolomics read-outs, developing cell-culture based metabolomics assays for drug testing, mentoring large genome-wide association studies, and running a bioinformatics core that analyzes whole genome sequences for metabolically relevant gene losses in Mendelian disorders.

Research topics

• Immunology
• Genetics
• Biology
• Cell biology

Selected publications

• Plasma proteomic associations with genetics and health in the UK Biobank

  Nature · 2023-10-04 · 1464 citations

  articleOpen access

  Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological validations, insights into proteomic disease signatures, and prediction modelling for various demographic and health indicators. We present comprehensive protein quantitative trait locus (pQTL) mapping of 2,923 proteins that identifies 14,287…

  PublisherOA PDFDOI

• Genetics meets proteomics: perspectives for large population-based studies

  Nature Reviews Genetics · 2020-08-28 · 490 citations

  review1st authorCorresponding
  PublisherDOI

• Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

  Nature Genetics · 2020-01-20 · 147 citations

  articleOpen access
  PublisherOA PDFDOI

• Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

  Antioxidants · 2021 · 34 citations

  Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), and type 2 diabetes (T2D). There is limited knowledge about molecular mechanisms that sustain inflammation in obese states. Here, we describe a robust and physiologically relevant in vitro system to trigger senescence in mouse 3T3-L1 preadipocytes. By employing transcriptomics an…

  PublisherOA PDFDOI

• Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

  Nature Communications · 2025-02-24 · 16 citations

  articleOpen access

  Impaired glucose uptake in the brain is an early presymptomatic manifestation of Alzheimer's disease (AD), with symptom-free periods of varying duration that likely reflect individual differences in metabolic resilience. We propose a systemic "bioenergetic capacity", the individual ability to maintain energy homeostasis under pathological conditions. Using fasting serum acylcarnitine profiles from the AD Neuroimaging Initiative as a blood-based readout for this capacity, we identified subgroups…

  PublisherOA PDFDOI

Frequent coauthors

• Jerzy Adamski

  University of Ljubljana

  583 shared

• Gabi Kastenmüller

  Helmholtz Zentrum München

  554 shared

• Annette Peters

  Deutsches Diabetes-Zentrum e.V.

  424 shared

• Christian Gieger

  Deutsches Diabetes-Zentrum e.V.

  406 shared

• Rui Wang‐Sattler

  Center for Environmental Health

  254 shared

• Jan Krumsiek

  Cornell University

  245 shared

• Werner Römisch‐Margl

  Helmholtz Zentrum München

  178 shared

• Thomas Illig

  German Center for Lung Research

  176 shared

Education

• Habilitation, Bioinformatics

  Aix-Marseille Université

  2004

• PhD, Atmospheric Chemistry and Meteorology

  Université Paul Sabatier

  1994

• Vordiplom, Mathematics

  Universität Osnabrück

  1991

• Diplom, Physics

  Universität Osnabrück

  1991

• Exchange Student (3rd year BSc), Applied Mathematics

  University of Hull

  1989

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