Kannanganattu V. Prasanth

About

Kannanganattu V. Prasanth is a Professor in the Department of Cell and Developmental Biology at the University of Illinois. His research focuses on the regulation of gene expression and RNA biology, with a particular emphasis on long noncoding RNAs (lncRNAs) and their roles in nuclear domain structure and breast cancer progression. Prasanth's laboratory investigates how lncRNAs localized within nuclear domains control gene expression, especially during cancer progression, using cellular and molecular biological approaches. His work has elucidated the functions of several lncRNAs in mammalian cells and their involvement in cancer, with ongoing studies dissecting the mechanisms by which lncRNAs regulate gene expression through modulation of nuclear domains and chromatin structure, cell cycle regulation, and cancer metastasis. A significant focus of Prasanth's research is on nuclear domain-enriched lncRNAs such as MALAT1, a highly conserved nuclear speckle-enriched lncRNA implicated in cancer progression and metastasis. His laboratory demonstrated MALAT1's role in alternative splicing of pre-mRNAs and the organization of splicing factors within nuclear speckles, contributing to understanding the molecular basis of MALAT1's physiological and pathological functions. Additionally, his group studies cell cycle-regulated lncRNAs that influence cell proliferation and cancer progression by regulating protein-coding genes and signaling pathways such as HIPPO. Prasanth's research also…

Research topics

• Biology
• Cell biology
• Genetics
• Cancer research
• Molecular biology
• Biochemistry

Selected publications

• A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

  eLife · 2020 · 107 citations

  demonstrate that FORCP is a novel, conserved small protein encoded by a mis-annotated lncRNA that regulates apoptosis and tumorigenicity in well-differentiated CRC cells.

  DOI

• The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma

  Genes & Development · 2020 · 69 citations

  splicing is vital for p53 function. Collectively, our findings uncover a p53-ZMAT3-CD44 axis in growth suppression in CRC cells.

  DOI

• Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death

  Nature Communications · 2023 · 44 citations

  Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its many roles in mRNA metabolism, it is also crucial for maintaining genome stability. We show that acute liver damage in the setting of targeted SRSF1 deletion in mice is associated with the excessive formation of deleterious RNA-DNA hybrids (R-loops), w…

  DOI

• The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway

  eLife · 2020 · 37 citations

  Senior authorCorresponding

  modulating the expression of genes controlling cell proliferation.

  PublisherDOI

• Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-<i>MIRHG</i> for efficient cell cycle reentry

  RNA · 2020 · 18 citations

  Senior authorCorresponding

  , which dictates cell cycle reentry.

  PublisherOA PDFDOI

Frequent coauthors

• Shinichi Nakagawa

  Osaka University

  129 shared

• Ruge Chen

  Hospital for Special Surgery

  115 shared

• Baohong Zhao

  Hospital for Special Surgery

  113 shared

• Yongli Qin

  Hospital for Special Surgery

  113 shared

• William M. Ricci

  Hospital for Special Surgery

  111 shared

• Cheng Xu

  Jianghan University

  107 shared

• Zhonghao Deng

  Nanfang Hospital

  107 shared

• Mahmoud Elguindy

  Neurological Surgery

  107 shared

Education

• post doctoral fellowship

  Cold Spring Harbor Laboratory

  2007

• Ph.D., Cytogenetics laboratory

  Banaras Hindu University

  2000

Awards & honors

• EAGER NSF award
• Research Scholar, American Cancer Society
• Cancer Center at Illinois seed grants

Similar researchers at University of Illinois Urbana-Champaign

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