About

Jung In Lee is a dual-title PhD student in the Departments of Applied Linguistics and Asian Studies at Pennsylvania State University. She holds a B.A. in English Language and Literature from Seoul National University of Science and Technology and an M.A. in TESOL with a concentration in Applied Linguistics from Portland State University. Her research interests include L2 Korean, phonology, and the intersection of language and sexuality. Her current work focuses on L2 phonology, with particular attention to Korean wh-indeterminate questions. She is actively involved in decolonial discourse within applied linguistics and advocates for more inclusive, accessible, and diverse forms of scholarship in academia.

Research topics

• Medicine
• Materials science
• Surgery
• Optoelectronics
• Internal medicine

Selected publications

• ID# 1885184 Real-World Clinical Outcomes from a Prospective, Multicenter Deep Brain Stimulation Registry of Essential Tremor Patients

  Neuromodulation Technology at the Neural Interface · 2025-09-23

  article
  PublisherDOI

• Intra-articular sigmoid notch fractures of the distal radius and their association with arthritis progression and outcomes after volar locking plate fixation: A retrospective study

  Medicine · 2025-10-10 · 1 citations

  articleOpen accessSenior authorCorresponding

  The relationship between distal radioulnar joint (DRUJ) involvement and subsequent arthritis or functional outcomes remains unclear. This study evaluated associations between DRUJ articular disruption, arthritis severity, and wrist function following volar locking plate fixation. We retrospectively reviewed patients with unstable distal radius fractures who underwent volar locking plate fixation and had a minimum follow-up of 1 year. Preoperative computerized tomography scans were analyzed for DRUJ articular involvement, articular step-off, and volar or dorsal subluxation. Patients were categorized by presence or absence of DRUJ involvement; presence or absence of sigmoid notch articular step-off; and degree of DRUJ subluxation (<10% vs ≥10%). The severity of DRUJ arthritis was assessed using the modified Kellgren-Lawrence criteria on plain radiographs taken at least 1 year after surgery. Functional outcomes were evaluated through grip strength, wrist range of motion, and the Quick Disabilities of the Arm, Shoulder, and Hand score. Fifty-seven patients were included; 47 had DRUJ involvement and 10 did not. Arthritis grades and functional outcomes did not differ significantly between patients with or without DRUJ involvement. Patients with sigmoid notch articular step-off (n = 34) had higher arthritis grades than those without (n = 13) (0.7 ± 0.6 vs 0.2 ± 0.3, P < .05), though functional outcomes were similar. Arthritis grades and function were comparable between patients with subluxation ≥ 10% (n = 18) and < 10% (n = 39). Sigmoid notch involvement was not associated with higher DRUJ arthritis severity or impaired function, whereas articular step-off correlated with increased arthritis grades without functional deficits. These findings suggest that while sigmoid notch involvement alone may not be a major determinant of functional outcome, careful attention to reducing articular step-off may help minimize the risk of radiographic arthritis progression.

  PublisherDOI

• Effects of 4-aminopyridine as an Adjuvant Therapy Following Peripheral Nerve Repair in an Animal Model of Nerve Transection Injury

  Journal of Reconstructive Microsurgery · 2025-03-07 · 1 citations

  article1st authorCorresponding

  Abstract Peripheral nerve repair is considered the gold standard treatment for complete nerve transection injuries, yet achieving satisfactory functional recovery remains challenging due to muscle atrophy during the time required for axonal regeneration. This study investigated the beneficial effects of 4-aminopyridine (4-AP), a potassium channel blocker, on neural and muscular recovery. Following complete transection of the right sciatic nerve, 40 mice underwent end-to-end nerve repair using microscopic epineural sutures and were randomly assigned to either the control or 4-AP groups immediately after surgery (n = 20 per group). The experimental animals were administered intraperitoneal injections of 200 μL normal saline or soluble 4-AP at a dose of 10 μg daily. The sciatic functional index (SFI) and nerve conduction studies were measured until 12 weeks postoperatively. Morphological analyses of nerve and muscle, and Western blotting for proteins associated with muscle atrophy were performed at 3 and 12 weeks after surgery. There were no significant differences in the SFI between the two groups. Nerve conduction study showed that 4-AP treatment increased the compound muscle action potential and decreased latency. A histomorphometric study showed that 4-AP treatment increased myelin thickness, G-ratio (axonal diameter/axoglial diameter on cross-sectioned nerve), cross-sectional area of myofibrils, and minimal Feret diameter of myofibrils. Additionally, expression levels of FoxO3 and mTORC1 were lower in the 4-AP treated mice, while myogenin expression levels showed no significant difference between the groups. 4-AP treatment promotes myelination and prevents denervation-induced muscle atrophy after neurorrhaphy. These findings suggest that 4-AP may be a promising candidate for clinical consideration as an adjuvant therapy following nerve repair for transection injuries.

  PublisherDOI

• Avulsion Fractures of around the Hand

  Journal of the Korean Fracture Society · 2024-01-01

  articleOpen accessSenior author

  An avulsion fracture occurs when soft tissues, including the tendons and ligaments, are forcibly detached from the main bone by an external force.The hand contains numerous anatomical structures, such as ligaments, tendons, and volar plates, which are essential for maintaining multidirectional motion and joint stability.Excessive force applied in a specific direction can damage these structures, leading to avulsion fractures around the joint.These fractures can result in severe complications if left untreated or improperly managed, including joint deformity, contracture, nonunion or malunion of the fracture, secondary osteoarthritis, and limited range of motion.Therefore, an accurate examination, diagnosis, and appropriate treatment are crucial for preventing these adverse outcomes.An avulsion fracture can be managed conservatively when the avulsed fragment does not compromise joint stability or motion.Nevertheless, surgical intervention is required to stabilize the fragment if it affects joint stability or motion.The use of internal fixation has become more prevalent because of recent advances in small implants for fixation.

  PublisherOA PDFDOI

• A comparative study of volar locking-plate fixation with corticocancellous and pure cancellous bone grafts for scaphoid nonunion with dorsal intercalated segmental instability secondary to scaphoid humpback deformity

  Injury · 2024-04-20 · 4 citations

  articleSenior authorCorresponding
  PublisherDOI

• Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study

  Orthopaedic Journal of Sports Medicine · 2023-07-01 · 10 citations

  articleOpen accessSenior authorCorresponding

  Background: Previous longitudinal cohort studies have reported the conflicting results of the relationship between statin use and the development of tendinopathy disorder. It is unclear if there is a relationship between statin use, particularly the type or cumulative doses, and the development of tendinopathy disorder. Purpose: To investigate an association between statin treatment and the development of tendinopathy. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 594,130 participants were enrolled in this study in 2002 and evaluated until 2015. There were 84,102 statin users and 168,204 nonusers (controls) selected at a ratio of 1:2 using propensity score matching analysis. The types of included tendinopathy were as follows: (1) trigger finger, (2) radial styloid tenosynovitis, (3) elbow epicondylitis, (4) rotator cuff tendinopathy, and (5) Achilles tendinitis. Cox proportional hazards models with time-varying covariates were constructed to identify the association between statin use and tendinopathy development. Results: Statin treatments regardless of statin types were associated with a significantly greater risk of all types of tendinopathy development (hazard ratio, 1.435; 95% CI, 1.411-1.460) compared with no statin treatment. A trend toward risk reduction was observed according to cumulative statin doses, which was indicated by hazard ratios of 2.337 (95% CI, 2.269-2.406), 2.210 (95% CI, 2.132-2.290), and 1.1 (95% CI, 1.098-1.146) in patients with cumulative defined daily doses of 90, 91-180, and >180, respectively. Conclusion: This nationwide population-based cohort study suggests that statin use regardless of the statin type was associated with a greater risk of tendinopathy compared with that of nonusers. The risk of tendinopathy development was diluted with the increasing cumulative defined daily dose.

  PublisherOA PDFDOI

• Surgical Outcomes of Percutaneous Pinning and Open Locking Plating in Patients With Intra-Articular Fractures of the Base of the Fifth Metacarpal

  The Journal Of Hand Surgery · 2023-05-06 · 6 citations

  article1st authorCorresponding
  PublisherDOI

• Association between alcohol consumption and severity of self-harm behaviors based on suicidal intent in patients admitted to the emergency department for self-harm

  Signa Vitae · 2023-01-01

  articleOpen access

  This study aimed to investigate the association between alcohol consumption and the severity of self-harm behaviors based on the suicidal intents of patients admitted to the emergency department (ED) for self-harm. This was a retrospective study on patients admitted to the ED between March 2017 and December 2020 owing to self-harm behaviors and were grouped into a suicide attempt (SA) and non-suicidal self-harm (NSSH) group. A total of 642 (73.5%) and 232 (26.5%) patients were classified into SA and NSSH groups, respectively. In the SA group, 270 (42.1%) patients reported consuming alcohol, which was independently associated with ≥12 years of formal education and no history of psychiatric hospitalization. In the NSSH group, 87 (37.5%) patients reported consuming alcohol, which was associated with male sex, being married or unmarried but living together, ≥12 years of formal education, and no history of depression. Alcohol consumption could predict ED disposition in the SA group but not in the NSSH group. The impact of alcohol consumption varied according to suicidal intents among patients admitted to the ED for self-harm behavior. Regardless of suicidal intent, patients with a higher education level tended to drink alcohol when engaging in self-harm behaviors.

  PublisherOA PDFDOI

• 510 Prospective, Multicenter, International Outcomes Study of Deep Brain Stimulation for Essential Tremor

  Neurosurgery · 2023-03-16

  article

  INTRODUCTION: Essential Tremor (ET) treatment is focused on medical management of motor symptoms and includes pharmacotherapy and ventral intermediate nucleus (VIM) thalamotomy, which is being largely replaced by thalamic Deep Brain Stimulation (DBS) as the surgical treatment of choice. DBS of the VIM thalamus is recommended as a therapeutic option for appropriate subjects with ET (Elble RJ., et al. Expert Rev Neurother. 2018). METHODS: This is a prospective, on-label, multi-center, international DBS outcomes study conducted at up to 50 implanting centers. All participants are implanted with a multiple-source, constant-current directional DBS system (Vercise, Boston Scientific). Subjects are followed for up to 3-years post implantation where their overall improvement in quality of life and ET symptoms are evaluated. Clinical endpoints evaluated at baseline and follow-up timepoints include: The Essential Tremor Rating Assessment Scale (TETRAS), Quality of Life in Essential Tremor Questionnaire (QUEST), Fahn-Tolosa-Marin Rating Scale (TRS), and Global Impression of Change. Adverse events also collected. RESULTS: To date, 18-implanted subjects with a mean disease duration of 15.1 ± 14.6-years and a baseline QUEST Summary Index score of 35.0 ± 12.4. At 6-months post-DBS, a clinically significant improvement in quality of life (∆ = 19.5-point change in QUEST SI score) was reported. In addition, a mean 9-hours of tremor reduction was noted (14-hours at Baseline, 6.9-hours at 6-months) in a typical day at 6-months. All subjects (100%) reported mild disability, and no subject reported moderate or marked disability (89% at baseline) as reported by TRS at 6 months. CONCLUSIONS: This work represents the first comprehensive, large scale collection of real-world outcomes and evaluation of safety and effectiveness of a multiple-source, constant-current DBS system capable of providing directionality for use in treatment of Essential Tremor.

  PublisherDOI

• Perilunate Dislocation and Perilunate Fracture-Dislocation

  Journal of the Korean Fracture Society · 2022-01-01 · 43 citations

  articleOpen access1st authorCorresponding
  PublisherDOI

Frequent coauthors

• Domenic A. Santavicca

  Pennsylvania State University

  28 shared

• Bryan D. Quay

  Pennsylvania State University

  22 shared

• Jinkwan Song

  General Electric (Israel)

  16 shared

• Kyu Tae Kim

  Pennsylvania State University

  11 shared

• Kwanwoo Kim

  7 shared

• Hyung Ju Lee

  Pukyong National University

  6 shared

• Chandrasekar Ramasubramanian

  University of Cincinnati

  4 shared

• Nicholas Tsolas

  Auburn University

  4 shared

Education

• Ph.D, College of Medicine

  Korea University