Joseph M. DeSimone

About

Joseph M. DeSimone is the Sanjiv Sam Gambhir Professor of Translational Medicine and Chemical Engineering at Stanford University. He holds appointments in the Departments of Radiology and Chemical Engineering, with courtesy appointments in the Department of Chemistry and in Stanford’s Graduate School of Business. His laboratory's research efforts are focused on developing innovative, interdisciplinary solutions to complex problems centered around advanced polymer 3D fabrication methods. In Chemical Engineering and Materials Science, the lab is pursuing new capabilities in digital 3D printing, as well as the synthesis of new polymers for use in advanced additive technologies. In Translational Medicine, research is focused on exploiting 3D digital fabrication tools to engineer new vaccine platforms, enhanced drug delivery approaches, and improved medical devices for numerous conditions, with a current major focus in pediatrics. Complementing these research areas, the DeSimone group has a third focus in Entrepreneurship, Digital Transformation, and Manufacturing.

Research topics

• Internal medicine
• Medicine
• Computer Science
• Materials science
• Nanotechnology
• Database
• Geography
• Cancer research
• Biology
• Intensive care medicine

Selected publications

• 3D-Printed Microarray Patches for Transdermal Applications

  JACS Au · 2022 · 55 citations

  Senior authorCorresponding

  The intradermal (ID) space has been actively explored as a means for drug delivery and diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray patches (MAPs) are comprised of a series of micrometer-sized projections that can painlessly puncture the skin and access the epidermal/dermal layer. MAPs have failed to reach their full potential because many of these platforms rely on dated lithographic manufacturing processes or molding processes that are not easily sc…

  DOI

• Opportunities at the Intersection of 3D Printed Polymers and Pyrolysis for the Microfabrication of Carbon-Based Energy Materials

  JACS Au · 2024-09-26 · 13 citations

  reviewOpen accessSenior author

  In an era marked by a growing demand for sustainable and high-performance materials, the convergence of additive manufacturing (AM), also known as 3D printing, and the thermal treatment, or pyrolysis, of polymers to form high surface area hierarchically structured carbon materials stands poised to catalyze transformative advancements across a spectrum of electrification and energy storage applications. Designing 3D printed polymers using low-cost resins specifically for conversion to high perfor…

  PublisherDOI

• High-resolution stereolithography: Negative spaces enabled by control of fluid mechanics

  Proceedings of the National Academy of Sciences · 2024-09-04 · 12 citations

  articleOpen accessSenior authorCorresponding

  Stereolithography enables the fabrication of three-dimensional (3D) freeform structures via light-induced polymerization. However, the accumulation of ultraviolet dose within resin trapped in negative spaces, such as microfluidic channels or voids, can result in the unintended closing, referred to as overcuring, of these negative spaces. We report the use of injection continuous liquid interface production to continuously displace resin at risk of overcuring in negative spaces created in previou…

  PublisherDOI

• Fabrication of 3D-Printed Carbon Microarchitected Structures with High Yield from Polyacrylonitrile Composites via Gel Infusion and Pyrolysis

  Chemistry of Materials · 2025-09-15 · 4 citations

  articleSenior authorCorresponding

  Fabrication of geometrically complex conductive carbon electrodes with micrometer-scale features via polymer 3D printing and pyrolysis enables precise control over precursor composition and structure geometry, enabling the development of a tunable electrode design space for electrochemical systems. Continuous liquid interface production 3D printing of lattices with high surface-to-volume ratios offers promise for producing polymer pyrolysis precursors with tailored microarchitected structures. H…

  PublisherDOI

• Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA Incorporation

  Bioconjugate Chemistry · 2025-02-25 · 4 citations

  articleSenior authorCorresponding

  Historically, RNA delivery via nanoparticles has primarily relied on encapsulation, as demonstrated by lipid nanoparticles in SARS-CoV-2 vaccines. Concerns about RNA degradation on nanoparticle surfaces initially limited the exploration of adsorption-based approaches. However, recent advancements have renewed interest in adsorption as a viable alternative. This Viewpoint explores the approaches of RNA incorporation in nanoparticles, comparing encapsulation, adsorption, and the combination of enc…

  PublisherDOI

Recent grants

• NIH Grant U54CA151652

  NIH · $9.2M · 2016

• NIH Grant DP1OD006432

  NIH · $2.2M · 2014

• EAGER:Meso-Polymers

  NSF · $279k · 2009–2012

Frequent coauthors

• Bharat Bhushan

  715 shared

• Bradley J. Nelson

  ETH Zurich

  288 shared

• S. Siva Sankara Sai

  Sri Sathya Sai Institute of Higher Learning

  270 shared

• Lixin Dong

  Zhongnan Hospital of Wuhan University

  263 shared

• Li Zhang

  Hong Kong Science and Technology Parks Corporation

  194 shared

• J. Christopher Luft

  171 shared

• Timothy J. Merkel

  169 shared

• Jason Li

  149 shared

Education

• Ph.D., Chemical Engineering

  University of North Carolina at Chapel Hill

  1989

• M.S., Chemical Engineering

  University of North Carolina at Chapel Hill

  1985

• B.S., Chemical Engineering

  University of North Carolina at Chapel Hill

  1983

Awards & honors

• National Medal of Technology and Innovation (2016)
• U.S. Presidential Green Chemistry Challenge Award (1997)
• American Chemical Society Award for Creative Invention (2005…
• Lemelson-MIT Prize (2008)
• NIH Director’s Pioneer Award (2009)

Similar researchers at Stanford University

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• Thomas Jaramilloh-147
• Matteo Cargnelloh-83