Jonathan Dranoff
· Professor of Medicine (Digestive Diseases); Director, Steatotic Liver Disease Program , Digestive Diseases, VA Connecticut Healthcare SystemYale University · Gastroenterology
Active 1998–2024
About
Jonathan Dranoff, MD, is a professor of medicine in the Section of Digestive Diseases at Yale School of Medicine. He is also the director of the Steatotic Liver Disease Program at the VA Connecticut Healthcare System. Dr. Dranoff is a physician and scholar with expertise in liver disease pathophysiology, focusing on areas such as drug-induced liver injury, including acetaminophen safety and toxicity in patients with advanced chronic liver disease. His research interests include exploring the effects of exercise and coffee consumption on steatotic liver disease, as well as investigating liver fibrosis, cirrhosis, non-alcoholic fatty liver disease, and the safety and efficacy of various treatments. His work involves population-based studies and clinical research aimed at understanding and managing liver conditions, particularly in relation to metabolic dysfunction, lean liver disease, and advanced fibrosis.
Research topics
- Internal medicine
- Gastroenterology
- Medicine
- Intensive care medicine
- Biology
- Endocrinology
- General surgery
- Biochemistry
- Pharmacology
- Pathology
Selected publications
Hepatology · 2024 · 141 citations
- Medicine
- Internal medicine
- Gastroenterology
Sterling, Richard K.; Duarte-Rojo, Andres; Patel, Keyur; Asrani, Sumeet K.; Alsawas, Mouaz; Dranoff, Jonathan A.; Fiel, Maria Isabel; Murad, M. Hassan; Leung, Daniel H.; Levine, Deborah; Taddei, Tamar H.; Taouli, Bachir; Rockey, Don C. Author Information
Digestive Diseases and Sciences · 2022 · 63 citations
- Medicine
- Internal medicine
- Gastroenterology
Toxicological Sciences · 2022 · 36 citations
- Medicine
- Internal medicine
- Gastroenterology
Better biomarkers to predict death early in acute liver failure (ALF) are needed. To that end, we obtained early (study day 1) and later (day 3) serum samples from transplant-free survivors (n = 28) and nonsurvivors (n = 30) of acetaminophen-induced ALF from the NIH-sponsored Acute Liver Failure Study Group and from control volunteers (n = 10). To identify proteins that increase early in serum during ALF, we selected individuals from this cohort for whom alanine aminotransferase was lower on day 1 than day 3, indicating a time point before peak injury (n = 10/group). We then performed untargeted proteomics on their day 1 samples. Out of 1682 quantifiable proteins, 361 were ≥ 4-fold elevated or decreased in ALF patients versus controls and 16 of those were further elevated or decreased ≥ 4-fold in nonsurvivors versus survivors, indicating potential to predict death. Interestingly, 1 of the biomarkers was lactate dehydrogenase (LDH), which is already measured in most clinical laboratories. To validate our proteomics results and to confirm the prognostic potential of LDH, we measured LDH activity in all day 1 and 3 samples from all 58 ALF patients. LDH was elevated in the nonsurvivors versus survivors on both days. In addition, it had prognostic value similar to the model for end-stage liver disease and outperformed the King's College Criteria, while a combination of model for end-stage liver disease and LDH together outperformed either alone. Finally, bioinformatics analysis of our proteomics data revealed alteration of numerous signaling pathways that may be important in liver regeneration. Overall, we conclude LDH can predict death in APAP-induced ALF.
Recent grants
Regulation of Hepatic Stellate Cells by Extracellular Nucleotides
NIH · $1.8M · 2008–2014
NIH · $649k · 2005
NIH · $164k · 2006
NIH · $386k · 2011
Regulation of hepatic stellate cells by intracellular calcium
NIH · $298k · 2006–2016
Frequent coauthors
- 74 shared
Michel Fausther
University of Arkansas for Medical Sciences
- 44 shared
Élise G. Lavoie
Université Laval
- 26 shared
Emir Tas
Arkansas Children's Hospital
- 25 shared
Nina Sheung
Milford Elementary School
- 24 shared
Eva C. Diaz
University of Arkansas for Medical Sciences
- 24 shared
Jean Sévigny
Hudson Institute of Medical Research
- 24 shared
Gianfranco Alpini
Richard L. Roudebush VA Medical Center
- 22 shared
Jesús M. Bañales
Similar researchers at Yale University
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Jonathan Dranoff
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup