John Ward
· LGBTQIA+ Rights LeaderBoston University · Law
Active 2000–2022
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
John Ward is a faculty member at Boston University School of Law. The provided page text does not include specific details about his research focus, background, or key contributions. Therefore, a detailed biography cannot be generated from the available information.
Research topics
- Medicine
- Pharmacology
- Chemistry
- Cardiology
- Organic chemistry
- Materials science
- Internal medicine
- Nanotechnology
Selected publications
Proceedings of the National Academy of Sciences · 2010-02-11 · 325 citations
articleOpen accessPatients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms underlying this deadly form of heart disease remain unclear. Although interstitial amyloid fibril deposition of Ig light chain proteins is a major cause of cardiac dysfunction in AL car…
Large and Small Animal Models of Heart Failure With Reduced Ejection Fraction
Circulation Research · 2022 · 84 citations
Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions that results in structural and functional remodeling leading to subsequent impairment of cardiac function, including either systolic dysfunction, diastolic dysfunction, or both. Several factors chronically lead to HF, including cardiac volume and pressure overload that may result from hypertension, valvular lesions, acute, or chronic ischemic injuries. Major forms of HF include hypertrophic, dilated, and rest…
Preclinical development of siRNA therapeutics for AL amyloidosis
Gene Therapy · 2011-05-12 · 38 citations
articleOpen accessAmyloid · 2012-11-05 · 22 citations
articleAL cardiomyopathy leading to heart failure (HF) represents a significant cause of morbidity and mortality in systemic amyloidosis. However, the paucity of robust in vivo models of AL-induced cardiac dysfunction has limited our ability to probe the mechanisms of AL heart disease. To address this problem, we have developed a model of AL HF in zebrafish embryos by injection of in vitro transcribed mRNA encoding amyloidogenic light chain (aLC) into fertilized oocytes. We demonstrate that expression…
Journal of Interferon & Cytokine Research · 2014-02-24 · 17 citations
articleOpen accessInterferon-alpha (IFN-α) has been identified as a neurotoxin that plays a prominent role in human immunodeficiency virus (HIV)-associated neurocognitive disorders and HIV encephalitis (HIVE) pathology. IFN-α is associated with cognitive dysfunction in other inflammatory diseases where IFN-α is upregulated. Trials of monoclonal anti-IFN-α antibodies have been generally disappointing possibly due to high specificity to limited IFN-α subtypes and low affinity. We investigated a novel IFN-α inhibito…
Frequent coauthors
- 33 shared
David C. Seldin
- 30 shared
Carl O’Hara
Boston Medical Center
- 27 shared
Lawreen H. Connors
Boston University
- 20 shared
Ronglih Liao
Amyloidosis Foundation
- 19 shared
Martha Skinner
University of Nottingham
- 18 shared
Vaishali Sanchorawala
Boston University
- 18 shared
Cynthia A. Kos
Johnson University
- 18 shared
Daniel G. Wright
University of Oxford
Education
- 2005
PhD, Microbiology
Boston University School of Medicine
- 1997
BS, Biology
Georgetown University
Similar researchers at Boston University
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with John Ward
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup