Jodi A. Flaws

About

Jodi A. Flaws is a professor in the Department of Bioengineering at the University of Illinois Urbana-Champaign. Her research primarily focuses on understanding the genetic and environmental factors that influence the female reproductive system. Her laboratory investigates key questions such as which genes and hormones regulate the normal development and function of the ovary, the effects of environmental toxicants on ovarian development and function, the mechanisms underlying reproductive toxicants' effects, and the association of environmental exposures with reproductive abnormalities in women. Her work involves exploring how various environmental toxicants, such as phthalates and bisphenol A, impact ovarian health and fertility, with a particular emphasis on the molecular pathways involved. Dr. Flaws has contributed to the scientific understanding of reproductive toxicology through her research, which has been published in numerous scientific journals.

Research topics

• Biology
• Endocrinology
• Chemistry
• Medicine
• Internal medicine
• Physiology
• Genetics
• Ecology
• Psychiatry
• Environmental health

Selected publications

• Endocrine Disruptors in Water and Their Effects on the Reproductive System

  International Journal of Molecular Sciences · 2020 · 315 citations

  Senior authorCorresponding

  Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. T…

  DOI

• The Impact of Environmental Chemicals on the Gut Microbiome

  Toxicological Sciences · 2020 · 184 citations

  Since the surge of microbiome research in the last decade, many studies have provided insight into the causes and consequences of changes in the gut microbiota. Among the multiple factors involved in regulating the microbiome, exogenous factors such as diet and environmental chemicals have been shown to alter the gut microbiome significantly. Although diet substantially contributes to changes in the gut microbiome, environmental chemicals are major contaminants in our food and are often overlook…

  PublisherOA PDFDOI

• Placental outcomes of phthalate exposure

  Reproductive Toxicology · 2021 · 77 citations

  DOI

• Iodoacetic acid disrupts mouse oocyte maturation by inducing oxidative stress and spindle abnormalities

  Environmental Pollution · 2020 · 36 citations

  DOI

• Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study

  Menopause The Journal of The North American Menopause Society · 2020 · 33 citations

  OBJECTIVE: Follicle-stimulating hormone and estradiol (E2) have been associated with sleep in midlife women, however, few studies have examined the association of other hormones or environmental chemical exposure such as phthalates, with self-reported sleep quality. We assessed the relationship of self-reported sleep with hormones and phthalates. METHODS: In total, 762 women (aged 45-54 y, 459 premenopausal, and 303 perimenopausal) from the Midlife Women's Health Study answered self-reported que…

  PublisherDOI

Recent grants

• NIH Grant U01ES020835

  NIH · $464k · 2017

• NIH Grant R01HD038955

  NIH · $950k · 2005

• NIH Grant R01ES012893

  NIH · $1.1M · 2010

Frequent coauthors

• Howard A. Zacur

  Johns Hopkins University

  103 shared

• Susan R. Miller

  Keck Hospital of USC

  92 shared

• Lisa Gallicchio

  National Cancer Institute

  83 shared

• Jonathan L. Tilly

  Northeastern University

  70 shared

• Gloria I. Perez

  Michigan State University

  68 shared

• Harry B. Greenberg

  Stanford University

  64 shared

• Andrea Jurisicova

  Sinai Health System

  64 shared

• Keith E. Latham

  Michigan State University

  64 shared

Awards & honors

• Fellow of the Academy of Toxicological Sciences, 2013-curren…
• Pfizer Animal Health Award for Research Excellence, 2009
• University Scholar, 2009-2012

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