Jivianne K. Lee
· MDUniversity of California, Los Angeles · Otolaryngology-Head and Neck Surgery
Active 1996–2024
About
Jivianne K. Lee, MD, is a Professor of Rhinology and Endoscopic Skull Base Surgery in the Department of Head and Neck Surgery at the UCLA David Geffen School of Medicine. She is fellowship trained in complex sinus and endoscopic cranial base surgery and specializes in minimally invasive surgical techniques for the treatment of sinonasal and skull base disease. Dr. Lee obtained her MD from UCLA School of Medicine in 1998, graduating with distinction and being inducted into the Alpha Omega Alpha Honor Medical Society. She completed her Otolaryngology-Head & Neck Surgery residency at UCLA Medical Center from 1998 to 2004, followed by a Rhinology & Endoscopic Skull Base Surgery subspecialty fellowship at the University of Pennsylvania from 2004 to 2005, under the mentorship of pioneers in endoscopic sinus surgery. Her research primarily focuses on investigating novel treatments and underlying mechanisms of chronic rhinosinusitis, including the roles of innate immunity, the sinonasal microbiome, and airborne pollutants and toxicants. Dr. Lee has contributed extensively to her field through over 145 peer-reviewed articles, textbook chapters, and numerous lectures both nationally and internationally. She holds multiple leadership positions in her specialty, including serving on the Board of Directors of the American Rhinologic Society, editorial boards for prominent journals, and as Vice-President of the American Rhinologic Society. Her work has been recognized with several awards for leadership, service, and contributions to rhinology and skull base surgery.
Research topics
- Medicine
- Anatomy
- Orthodontics
- Psychiatry
- Chemistry
- Clinical psychology
- Biology
- Cell biology
- Psychology
- Surgery
Selected publications
Effect of Gender-affirming Facial Feminization Surgery on Psychosocial Outcomes
Annals of Surgery · 2022 · 83 citations
Senior authorCorresponding- Medicine
- Clinical psychology
- Psychiatry
OBJECTIVE: This study investigates the effect of gender-affirming facial feminization surgery (FFS) on psychosocial outcomes in patients with gender dysphoria. BACKGROUND: Comprehensive analyses of psychosocial outcomes after gender-affirming FFS are absent in the literature resulting in a paucity of information on the impact of FFS on quality of life as well as ramifications in health insurance coverage of FFS. METHODS: Scores from 11 validated, quantitative instruments from the Patient-Reported Outcomes Measurement Information System (PROMIS) assessing anxiety, anger, depression, global mental health, global physical health, satisfaction with sex life, positive affect, emotional support, social isolation, companionship, and meaning and purpose. Patients within the preoperative group (pre-FFS) were evaluated >30 days before surgery and patients within the postoperative group (post-FFS) were evaluated ≥10 weeks after surgery. RESULTS: A total of 169 patients [mean (SD) age, 33.5 (10.8) years] were included. Compared with the pre-FFS group (n=107), the post-FFS group (n=62) reported improved scores anxiety (56.8±8.8 vs 60.1±7.9, P =0.01), anger (47.4±7.6 vs 51.2±9.6, P =0.01), depression (52.2±9.2 vs 57.0±8.9, P =0.001), positive affect (46.6±8.9 vs 42.9±8.7, P =0.01), meaning and purpose (49.9±10.7 vs 46.2±10.5, P =0.03), global mental health (46.7±7.6 vs 43.1±9.2, P =0.01), and social isolation (52.2±7.5 vs 55.4±7.4, P =0.01). Multivariable analysis to account for the effects of other gender-affirming surgeries, hormone therapy duration, preexisting mental health diagnoses, socioeconomic disparities, and patient-reported quality of social relationships on psychosocial functioning demonstrated that completion of FFS was independently predictive of improved scores. CONCLUSIONS: Gender-affirming FFS improves the quality of life by multiple psychosocial domains in transfeminine patients.
Archives of Plastic Surgery · 2021 · 40 citations
Senior authorCorresponding- Medicine
- Surgery
- Orthodontics
Facial feminization surgery (FFS) incorporates aesthetic and craniofacial surgical principles and techniques to feminize masculine facial features and facilitate gender transitioning. A detailed understanding of the defining male and female facial characteristics is essential for success. In this first part of a two-part series, we discuss key aspects of the general preoperative consultation that should be considered when evaluating the prospective facial feminization patient. Assessment of the forehead, orbits, hairline, eyebrows, eyes, and nose and the associated procedures, including scalp advancement, supraorbital rim reduction, setback of the anterior table of the frontal sinus, rhinoplasty, and soft tissue modifications of the upper and midface are discussed. In the second part of this series, bony manipulation of the midface, mandible, and chin, as well as soft tissue modification of the nasolabial complex and chondrolaryngoplasty are discussed. Finally, a review of the literature on patient-reported outcomes in this population following FFS is provided.
Macromolecular Bioscience · 2020 · 45 citations
Senior authorCorresponding- Cell biology
- Chemistry
- Biology
The ability of the extracellular matrix (ECM) to instruct progenitor cell differentiation has generated excitement for the development of materials-based regenerative solutions. Described a nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material capable of inducing in vivo skull regeneration without exogenous growth factors or ex vivo progenitor cell-priming is described previously. Here, the contribution of titrating stiffness to osteogenicity is evaluated by comparing noncrosslinked (NX-MC) and crosslinked (MC) forms of MC-GAG. While both materials are osteogenic, MC demonstrates an increased expression of osteogenic markers and mineralization compared to NX-MC. Both materials are capable of autogenously activating the canonical BMPR signaling pathway with phosphorylation of Smad1/5. However, unlike NX-MC, human mesenchymal stem cells cultured on MC demonstrate significant elevations in the major mechanotransduction mediators YAP and TAZ expression, coincident with β-catenin activation in the canonical Wnt signaling pathway. Inhibition of YAP/TAZ activation reduces osteogenic expression, mineralization, and β-catenin activation in MC, with less of an effect on NX-MC. YAP/TAZ inhibition also results in a reciprocal increase in Smad1/5 phosphorylation and BMP2 expression. The results indicate that increasing MC-GAG stiffness induces osteogenic differentiation via the mechanotransduction mediators YAP/TAZ and the canonical Wnt signaling pathway, whereas the canonical BMPR signaling pathway is activated independent of stiffness.
Recent grants
Osteoclast modulatory biomaterials for skull regeneration
NIH · $1.9M · 2020–2026
Human Bone Engineering and Resorption in a Novel Mineralized Collagen Scaffold
NIH · 2015–2020
NIH · $1.9M · 2019–2025
Frequent coauthors
- 112 shared
Anthony A. Bertrand
Université Paris Cité
- 102 shared
Miles J. Pfaff
Children's Hospital of Orange County
- 95 shared
Libby F. Wilson
Orthopaedic Institute for Children
- 93 shared
James P. Bradley
- 80 shared
Xiaoyan Ren
Chengdu Medical College
- 72 shared
Candace H. Chan
Oregon Health & Science University
- 70 shared
Kelly X. Huang
University of California, Los Angeles
- 68 shared
James P. Bradley
University of Pittsburgh Medical Center
Awards & honors
- American Rhinologic Society – Distinguished Leadership Award…
- American Academy of Otolaryngology-Head & Neck Surgery Found…
- American Rhinologic Society – Distinguished Leadership Award…
- American Rhinologic Society Presidential Citation Award (202…
- American Rhinologic Society – Distinguished Leadership Award…
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