Jie Zheng

About

Jie Zheng is a Professor-in-Residence in the Department of Ophthalmology at the University of California, Los Angeles (UCLA). His research focuses on characterizing the expression profile of Dexras1 in human trabecular meshwork cells, investigating extracellular vesicles derived from corneal stromal stem cells and their effects on ANGPTL7 expression, and advancing the diagnosis and management of limbal stem cell deficiency. Zheng's work also includes studying the activation and therapeutic potential of Wnt proteins, as well as exploring metabolic profiles of trabecular meshwork cells treated with dexamethasone. His contributions extend to structural and functional insights into protein interactions relevant to cell adhesion and signaling pathways, as well as drug discovery efforts targeting Wnt signaling pathways. Zheng has authored numerous publications in the fields of biochemistry, cell biology, and vision science, emphasizing his expertise in molecular mechanisms underlying ocular health and disease.

Research topics

• Biology
• Chemistry
• Cell biology
• Medicine
• Biochemistry

Selected publications

• HIF‑1α in myocardial ischemia‑reperfusion injury (Review)

  Molecular Medicine Reports · 2021-03-12 · 147 citations

  reviewOpen access1st author

  Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium following the recovery of blood flow. Currently, there is no effective treatment for MIRI in clinical practice. Over the past two decades, biological studies of hypoxia and hypoxia‑inducible factor‑1α (HIF‑1α) have notably improved understanding of oxygen homeostasis. HIF‑1α is an oxygen‑sensitive transcription factor that mediates adaptive metabolic responses to hypoxia and serves a pivotal role in MIRI.…

  PublisherOA PDFDOI

• Human limbal epithelial stem cell regulation, bioengineering and function

  Progress in Retinal and Eye Research · 2021-03-07 · 112 citations

  reviewOpen access
  PublisherOA PDFDOI

• Premise and peril of Wnt signaling activation through GSK-3β inhibition

  iScience · 2022-03-25 · 77 citations

  reviewOpen accessSenior authorCorresponding

  Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders. β-Catenin plays a central role in the most studied Wnt pathways, the Wnt/β-catenin signaling pathway, commonly referred to as the canonical Wnt signaling pathway. β-catenin is a substrate of glycogen synthase kinase 3β (GSK-3β), and the phosphorylated β-catenin by GSK-3β can be degraded by the proteasome through ubiquitination. Thus, GSK-3…

  PublisherOA PDFDOI

• Somatic Mutations within Myocilin due to Aging May Be a Potential Risk Factor for Glaucoma

  Genes · 2024-02-04 · 2 citations

  articleOpen accessSenior authorCorresponding

  Glaucoma is a chronic optic neuropathy that leads to irreversible vision loss. Aging and family history are the two most important risk factors of glaucoma. One of the most studied genes involved in the onset of open-angle glaucoma is myocilin (MYOC). About 105 germline mutations within MYOC are known to be associated with glaucoma and result in endoplasmic reticulum (ER) stress, which leads to trabecular meshwork (TM) cell death and subsequent intraocular pressure (IOP) elevation. However, only…

  PublisherOA PDFDOI

• Advances in the Diagnosis and Management of Limbal Stem Cell Deficiency

  Cornea · 2024-12-19 · 2 citations

  reviewOpen access

  ABSTRACT: This concise review focuses on the latest advancements in the diagnosis and management of limbal stem cell deficiency (LSCD). Ensuring the standard of care for individuals affected by LSCD involves the crucial task for physicians to meticulously and accurately diagnose the condition and determine its specific stage. A standardized diagnostic approach forms the foundation for formulating and delivering customized therapeutic interventions to maximize treatment outcomes for each patient.…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01GM069916

  NIH · $1.3M · 2009

• NIH Grant R01GM100909

  NIH · $1.5M · 2017

• Development of small-molecule Wnt mimetics for corneal epithelial cell regeneration

  NIH · $2.0M · 2018–2023

Frequent coauthors

• Robert Callender

  Albert Einstein College of Medicine

  36 shared

• Clémence Bonnet

  Centre de Recherche des Cordeliers

  35 shared

• Sophie X. Deng

  University of California, Los Angeles

  30 shared

• Ju Bao

  26 shared

• John W. Burgner

  22 shared

• Jufang Shan

  22 shared

• David Cowburn

  Albert Einstein College of Medicine

  21 shared

• Ho‐Jin Lee

  LeMoyne–Owen College

  20 shared

Labs

• Jie Zheng LabPI

Awards & honors

• Suzanne Eaton, Ph.D. Memorial Prize
• Taylor M. Brown Memorial Award
• Asrican Sophie & Jack Award

Similar researchers at University of California, Los Angeles

• V. Reggie Edgertonh-115
• Nicholas Brechah-88
• Mirella Daprettoh-84