Jennifer Johnson

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Biological Psychiatry · 2021 · 240 citations

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Biological Psychiatry · 2021 · 135 citations

BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,94…

Translational genomics of osteoarthritis in 1,962,069 individuals

Nature · 2025-04-09 · 53 citations

. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including tr…

Validating Online Parent‐ and Self‐Report Screening Methods for Avoidant/Restrictive Food Intake Disorder

International Journal of Eating Disorders · 2025-02-07 · 11 citations

OBJECTIVE: Although several assessments have been developed to diagnose or measure avoidant/restrictive food intake disorder (ARFID) symptoms, few studies have validated these tools in nonclinical and adult samples. This study explored the validity of two self- and parent/guardian-report ARFID screening measures in identifying adults and children who may have ARFID within a large community sample. METHOD: Fifty participants (divided into two groups: 25 adults and 25 parents/guardians of children…

Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes

medRxiv · 2025-02-04 · 9 citations

Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of binge eating behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six loci associated with BE, including loci associate…