Jeffrey D. Hartgerink

About

Jeffrey D. Hartgerink is a Professor of Chemistry and Bioengineering at Rice University, serving as the Vice Chair of the Department of Chemistry. His research focuses on supramolecular chemistry, an emerging sub-discipline concerned with non-covalent intermolecular interactions that are used to create nanometer-sized objects through parallel assembly. His work draws inspiration from biological systems and aims to mimic their structures and creation processes. Hartgerink's research addresses the challenge of manipulating and organizing supramolecular structures into higher-order assemblies by employing methods such as covalent capture and mineralization to develop complex and functional materials. He leads projects that include the self-assembly of coiled-coils for creating nanowires capable of interfacing with neural networks, the synthesis of artificial extracellular matrices for drug and cell delivery in tissue regeneration, and the development of novel catalysts and magnetic materials inspired by biomineralization processes. His research areas include chemical biology and nanomaterial synthesis.

Research topics

• Medicine
• Surgery
• Chemistry
• Internal medicine
• Materials science
• Biomedical engineering
• Nanotechnology
• Anatomy
• Cancer research
• Biology

Selected publications

• A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

  Nature Biomedical Engineering · 2022 · 224 citations

  Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerv…

  DOI

• Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy

  Journal for ImmunoTherapy of Cancer · 2021 · 127 citations

  BACKGROUND: Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers to tumor immunity. However, we have previously shown that off-target delivery is a substantial problem during intratumoral injections; this can lead to diminished drug efficacy and systemic toxicities. We have identified three variables that influence intratumoral drug delivery: injection technique, drug formulation and tumor microenvironment. The purpose of this study was…

  DOI

• Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury

  Biomaterials · 2020 · 83 citations

  Senior authorCorresponding
  DOI

• Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics

  Nature Nanotechnology · 2025-09-10 · 20 citations

  articleOpen access
  PublisherOA PDFDOI

• Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding

  Nature Chemistry · 2024-07-15 · 17 citations

  articleSenior author
  PublisherDOI

Recent grants

• CAREER: Design, Synthesis and Application of Self-Assembled ABC Nanofibers

  NSF · $550k · 2007–2012

• NIH Grant R01DE02179801A1

  NIH · $383k · 2016

• Self-Assembly of Collagen-like Octadecamers Based on the Stem Region of C1q and Related Proteins

  NSF · $455k · 2022–2025

Frequent coauthors

• Rena N. D’Souza

  National Institutes of Health

  19 shared

• Kerstin M. Galler

  Universitätsklinikum Erlangen

  16 shared

• Joseph W. R. Swain

  Rice University

  15 shared

• Lorenzo Aulisa

  GreenLight Biosciences (United States)

  14 shared

• Vivek Kumar

  New Jersey Institute of Technology

  14 shared

• Simon Young

  13 shared

• Navindee C. Wickremasinghe

  Rice University

  13 shared

• Abhishek A. Jalan

  University of Bayreuth

  12 shared

Labs

• HARTGERINK RESEARCH GROUPPI

  Not provided

Education

• Ph.D., Molecular and Cellular Structure and Chemistry

  The Scripps Research Institute

  1999

• A.B.

  Washington University in Saint Louis

  1993

Similar researchers at Rice University

• Peter Rosskyh-85
• R. Bruce Weismanh-66
• David Sarlahh-55