Jarcy Zee

Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains

Kidney International · 2020 · 193 citations

Serum Biomarkers of Iron Stores Are Associated with Increased Risk of All-Cause Mortality and Cardiovascular Events in Nondialysis CKD Patients, with or without Anemia

Journal of the American Society of Nephrology · 2021-07-08 · 84 citations

Significance Statement Management of iron deficiency in patients with nondialysis CKD focuses on improving erythropoiesis. Studies in patients with heart failure with similar iron deficiency pathogenesis found that treating iron deficiency improves cardiovascular outcomes, regardless of anemia. To evaluate a possible anemia-independent association of iron stores with outcomes in individuals with nondialysis CKD, the authors studied patients in nephrology-based clinics from a multinational cohort…

International Comparisons of Native Arteriovenous Fistula Patency and Time to Becoming Catheter-Free: Findings From the Dialysis Outcomes and Practice Patterns Study (DOPPS)

American Journal of Kidney Diseases · 2020-09-21 · 76 citations

Rationale & ObjectiveOptimizing vascular access use is crucial for long-term hemodialysis patient care. Because vascular access use varies internationally, we examined international differences in arteriovenous fistula (AVF) patency and time to becoming catheter-free for patients receiving a new AVF.Study DesignProspective cohort study.Setting & Participants2,191 AVFs newly created in 2,040 hemodialysis patients in 2009 to 2015 at 466 randomly selected facilities in the Dialysis Outcomes and Pra…

Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis

Journal of the American Society of Nephrology · 2022 · 50 citations

BACKGROUND: Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the Nephrotic Syndrome Study Network (NEPTUNE). METHODS: Forty-eight histologic (37 glomerular, 9 tubulointerstitial, 2 vascular) and 20 ultrastructural descriptors were quantified by applying the NEPTUNE Dig…

Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease

Journal of the American Heart Association · 2025-12-11 · 2 citations

BACKGROUND: Uterine fibroids and atherosclerotic cardiovascular disease (ASCVD) share biological pathways, yet whether risk of ASCVD is different among those with fibroids compared with those without remains unexplored in large US cohorts with longitudinal data. This study assessed the association between uterine fibroids and risk of incident ASCVD. METHODS: A US population-based cohort study was done using Optum's de-identified Clinformatics Data Mart Database (2000-2022). Follow-up continued u…