About

Dr. James J. Farrell is a leading expert in the field of gastrointestinal and pancreatic cancer prevention. His research focuses on early detection, risk assessment, and genetic predispositions to pancreatic cancer. Dr. Farrell's work involves the development of personalized care plans for patients at increased risk of pancreas cancer, utilizing a multidisciplinary approach involving genetic counselors, nurse practitioners, and physicians.

Research topics

• Medicine
• Internal medicine
• Gastroenterology
• Pathology
• General surgery
• Radiology

Selected publications

• The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival

  Journal of Clinical Oncology · 2022 · 213 citations

  • Medicine
  • Internal medicine
  • Gastroenterology

  PURPOSE: To report pancreas surveillance outcomes of high-risk individuals within the multicenter Cancer of Pancreas Screening-5 (CAPS5) study and to update outcomes of patients enrolled in prior CAPS studies. METHODS: higher-stage). Overall survival was determined using the Kaplan-Meier method. RESULTS: = .003). CONCLUSION: Most pancreatic cancers diagnosed within the CAPS high-risk cohort in the recent years have had stage I disease with long-term survival.

  DOI

• Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study

  BMJ Open Gastroenterology · 2021 · 67 citations

  • Medicine
  • Gastroenterology
  • Internal medicine

  BACKGROUND: Although evidence suggests frequent gastrointestinal (GI) involvement during coronavirus disease 2019 (COVID-19), endoscopic findings are scarcely reported. AIMS: We aimed at registering endoscopic abnormalities and potentially associated risk factors among patients with COVID-19. METHODS: or Fisher's exact test were used to compare patients with major abnormalities to those with negative procedures, and multivariate logistic regression to identify independent predictors. RESULTS: Between February and May 2020, during the first pandemic outbreak with severely restricted endoscopy activity, 114 endoscopies on 106 patients with COVID-19 were performed in 16 institutions (men=70.8%, median age=68 (58-74); 33% admitted in intensive care unit; 44.4% reporting GI symptoms). 66.7% endoscopies were urgent, mainly for overt GI bleeding. 52 (45.6%) patients had major abnormalities, whereas 13 bled from previous conditions. The most prevalent upper GI abnormalities were ulcers (25.3%), erosive/ulcerative gastro-duodenopathy (16.1%) and petechial/haemorrhagic gastropathy (9.2%). Among lower GI endoscopies, 33.3% showed an ischaemic-like colitis.Receiver operating curve analysis identified D-dimers >1850 ng/mL as predicting major abnormalities. Only D-dimers >1850 ng/mL (OR=12.12 (1.69-86.87)) and presence of GI symptoms (OR=6.17 (1.13-33.67)) were independently associated with major abnormalities at multivariate analysis. CONCLUSION: In this highly selected cohort of hospitalised patients with COVID-19 requiring endoscopy, almost half showed acute mucosal injuries and more than one-third of lower GI endoscopies had features of ischaemic colitis. Among the hospitalisation-related and patient-related variables evaluated in this study, D-dimers above 1850 ng/mL was the most useful at predicting major mucosal abnormalities at endoscopy. TRIAL REGISTRATION NUMBER: ClinicalTrial.gov (ID: NCT04318366).

  DOI

• Endoscopic ultrasound (EUS) and the management of pancreatic cancer

  BMJ Open Gastroenterology · 2020 · 76 citations

  Senior authorCorresponding
  • Medicine
  • Radiology
  • General surgery

  Pancreatic cancer is one of the leading causes of cancer-related mortality in western countries. Early diagnosis of pancreatic cancers plays a key role in the management by identification of patients who are surgical candidates. The advancement in the radiological imaging and interventional endoscopy (including endoscopic ultrasound (EUS), endoscopic retrograde cholangiopancreatography and endoscopic enteral stenting techniques) has a significant impact in the diagnostic evaluation, staging and treatment of pancreatic cancer. The multidisciplinary involvement of radiology, gastroenterology, medical oncology and surgical oncology is central to the management of patients with pancreatic cancers. This review aims to highlight the diagnostic and therapeutic role of EUS in the management of patients with pancreatic malignancy, especially pancreatic ductal adenocarcinoma.

  DOI

Frequent coauthors

• Oscar J. Hines

  89 shared

• Howard A. Reber

  85 shared

• Siavash K. Kurdistani

  81 shared

• Sheila Tze

  University of California, Los Angeles

  81 shared

• Gardenia Cheung-Lau

  81 shared

• Rebecca Paulus

  NRG Oncology

  81 shared

• Nicole A. Dawson

  81 shared

• Steve Horvath

  University of California, San Diego

  81 shared

Labs

• Pancreatic Cancer Early Detection ClinicPI

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