Jack Elias

About

Jack Elias is a Professor of Molecular Microbiology and Immunology at Brown University, holding the Warren Alpert Professorship in the Brown Institute for Translational Science. He is affiliated with the Division of Biology and Medicine at Brown University and is involved in research within the field of molecular microbiology and immunology. His work focuses on understanding the molecular mechanisms underlying microbial and immune system functions, contributing to advancements in translational science and medical research. As a faculty member, he is engaged in teaching, mentoring, and leading research initiatives aimed at elucidating complex biological processes related to microbiology and immunology.

Research topics

• Virology
• Medicine
• Internal medicine

Selected publications

• <i>Chi3l1</i> /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

  Science Translational Medicine · 2020-12-16 · 221 citations

  articleOpen access

  Chi3l1 /YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.

  PublisherOA PDFDOI

• Potential role of chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) in neurodegeneration and Alzheimer's disease

  Alzheimer s & Dementia · 2022-03-02 · 148 citations

  articleOpen access

  Chitinase-3-like protein 1 (CHI3L1/YKL-40) has long been known as a biomarker for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD). In the brain, CHI3L1 is primarily provided by astrocytes and heralds the reactive, neurotoxic state triggered by inflammation and other stress signals. However, how CHI3L1 acts in neuroinflammation or how it contributes to AD and relevant neurodegenerative conditions remains unknown. In peripheral tissues, our group and others h…

  PublisherOA PDFDOI

• Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

  The Lancet Child & Adolescent Health · 2024 · 34 citations

  BACKGROUND: Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 re…

  DOI

• CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease

  Science Advances · 2025-07-18 · 12 citations

  articleOpen access

  CHI3L1/YKL-40 is an astrocyte-secreted glycoprotein recognized as a biomarker of CNS inflammation and implicated in Alzheimer's disease (AD) cognitive decline. However, its precise pathological role remains unclear. Here, we investigate CHI3L1's function and its therapeutic potential in AD using both human induced pluripotent stem cell-derived neurogenesis models and in vivo conditional AD mouse models, with astrocyte-specific CHI3L1 knockout, alongside 5XFAD mice. Our data reveal that CHI3L1 se…

  PublisherDOI

• Chitinase 3–like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα– and CD24-Siglec10–Mediated Phagocytosis

  The Journal of Immunology · 2024-09-18 · 8 citations

  articleOpen accessSenior author

  Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary disease (COPD). Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it inhibits adaptive immune responses by stimulating immune checkpoint molecules (ICPs) and portends a poor prog…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01HL078744

  NIH · $2.0M · 2010

• NIH Grant R01HL054989

  NIH · $1.2M · 1999

• NIH Grant R01HL061904

  NIH · $1.5M · 2002

Frequent coauthors

• Chun Geun Lee

  525 shared

• Robert J. Homer

  170 shared

• Suchitra Kamle

  University of Rhode Island

  141 shared

• Chang-Min Lee

  Brown University

  103 shared

• Bing Ma

  98 shared

• Zhou Zhu

  Chinese Academy of Medical Sciences & Peking Union Medical College

  98 shared

• Bedia Akosman

  80 shared

• Yang Zhou

  Central South University

  73 shared

Education

• MD, Medical School

  University of Pennsylvania

  1976

• B.A., Biology

  University of Pennsylvania

  1973

Awards & honors

• Warren Alpert Professorship in the Brown Institute for Trans…

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