Indrani C. Bagchi
University of Illinois Urbana-Champaign · Department of Biomedical and Translational Sciences
Active 1987–2026
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About
Indrani C Bagchi is a professor in the Biomedical and Translational Sciences department at the Carle Illinois College of Medicine, University of Illinois Urbana-Champaign. She is involved in teaching courses such as Reproductive Physiology, Animal Sciences Seminar, and Structure and Function III. Her research focus includes biomedical and translational sciences, with recent news indicating her involvement in developing tools to track inflammation in human tissue in collaboration with the Chan Zuckerberg Biohub Chicago Investigators. She contributes to the college's mission of reengineering medicine through her academic and research activities, supporting innovation and translational research in health sciences.
Research topics
- Biology
- Endocrinology
- Genetics
- Physiology
- Chemistry
- Cell biology
- Cancer research
- Medicine
- Bioinformatics
- Internal medicine
Selected publications
Placental outcomes of phthalate exposure
Reproductive Toxicology · 2021 · 77 citations
Proceedings of the National Academy of Sciences · 2022 · 70 citations
In humans, the uterus undergoes a dramatic transformation to form an endometrial stroma-derived secretory tissue, termed decidua, during early pregnancy. The decidua secretes various factors that act in an autocrine/paracrine manner to promote stromal differentiation, facilitate maternal angiogenesis, and influence trophoblast differentiation and development, which are critical for the formation of a functional placenta. Here, we investigated the mechanisms by which decidual cells communicate wi…
Proceedings of the National Academy of Sciences · 2020 · 45 citations
Senior authorCorrespondingImplantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in the endometrium. These events are followed by the formation of an extensive vascular network in the stroma that supports embryonic growth and ensures successful implantation. Interestingly, in many mammalian species, these processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying maternal adaptation to…
Cells · 2023 · 33 citations
There are several critical events that occur in the uterus during early pregnancy which are necessary for the establishment and maintenance of pregnancy. These events include blastocyst implantation, uterine decidualization, uterine neoangiogenesis, differentiation of trophoblast stem cells into different trophoblast cell lineages, and formation of a placenta. These processes involve several different cell types within the pregnant uterus. Communication between these cell types must be intricate…
Cell Death Discovery · 2024-06-15 · 30 citations
articleOpen accessAs the mean age of first-time mothers increases in the industrialized world, inquiries into causes of human reproductive senescence have followed. Rates of ovulatory dysfunction and oocyte aneuploidy parallel chronological age, but poor reproductive outcomes in women older than 35 years are also attributed to endometrial senescence. The current studies, using primary human endometrial stromal cell (ESC) cultures as an in vitro model for endometrial aging, characterize the proinflammatory cytokin…
Recent grants
Role of Hypoxia in Regulating Stromal-Epithelial Communication during Pregnancy
NIH · $1.6M · 2018–2024
NIH · $55.5M · 2017
NIH · $1.3M · 2004
Frequent coauthors
- 179 shared
Milan K. Bagchi
- 47 shared
Quanxi Li
Gansu Agricultural University
- 42 shared
Athilakshmi Kannan
- 36 shared
Francesco J. DeMayo
National Institute of Environmental Health Sciences
- 35 shared
Mary J. Laws
University of Illinois Urbana-Champaign
- 31 shared
Robert N. Taylor
Jacobs (United States)
- 31 shared
John P. Lydon
Baylor College of Medicine
- 15 shared
Li-Ji Zhu
Merck & Co., Inc., Rahway, NJ, USA (United States)
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