Igor Slukvin

About

Igor Slukvin is the Henry Pitot Professor in Pathology and Laboratory Medicine at the University of Wisconsin School of Medicine and Public Health. His research interests focus on understanding the cellular and molecular pathways that lead to the development of hematopoietic and vascular cells from human pluripotent stem cells (hPSCs). He works on advancing induced pluripotent stem cell (iPSC) technologies for hematopoietic stem cell (HSC) transplantation and immunotherapies. His work also aims to establish next-generation animal models and tools for assessing precision stem cell therapies, which are vital for developing novel sources of cells for bone marrow transplantation, transfusion, and immunotherapies for cancer and AIDS.

Research topics

• Biology
• Genetics
• Pathology
• Cell biology
• Medicine
• Internal medicine
• Ophthalmology
• Immunology
• Neuroscience
• Biochemistry

Selected publications

• Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study

  Nature Medicine · 2020 · 284 citations

  DOI

• Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies

  Stem Cell Reports · 2023 · 86 citations

  Senior authorCorresponding

  Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for treating solid tumors. However, genetic engineering and scalable production of somatic macrophages remains significant challenges. Here, we used CRISPR-Cas9 gene editing methods to integrate an anti-GD2 CAR into the AAVS1 locus of human pluripotent stem cells (hPSCs). We then established a serum- and feeder-free differentiation protocol for generating CAR macrophages (CAR-Ms) through arterial endothelial-to-…

  PublisherOA PDFDOI

• 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration

  Cell stem cell · 2021 · 64 citations

  DOI

• The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor

  Nature Communications · 2024-08-07 · 18 citations

  articleOpen access

  Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR-knockout screens with multiple arteriviruses. Using a panel of cell lines and divergent arteriviruses, we demonstrate that FcRn is required for the entry step of arterivirus infection and serves as a molecular barrier to arterivirus cross-species infec…

  PublisherDOI

• PTP1B phosphatase puts a brake on iPSC-derived neutrophil motility and antimicrobial function

  bioRxiv (Cold Spring Harbor Laboratory) · 2023-06-07 · 17 citations

  preprintOpen access

  Abstract Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Neutropenic patients are at high risk for fungal and bacterial infections and can benefit from granulocyte transfusion therapy. Human induced pluripotent stem cells (iPSCs) could provide a robust source of neutrophil-like cells for infusion as they can be generated in large quantities and do not require a donor. However, dampened intracellular signaling limits their cellular activation and r…

  PublisherOA PDFDOI

Recent grants

• Nonhuman Primate Model for Preclinical Evaluation of Haplotype-Based iPSC Banking for HLA-matched Blood Products

  NIH · $2.5M · 2016–2021

• NIH Grant P51RR000167

  NIH · $61.8M · 2013

• iPSC-based blood regenerative therapies for AIDS

  NIH · $3.4M · 2013–2019

Frequent coauthors

• James A. Thomson

  Morgridge Institute for Research

  98 shared

• Maxim A. Vodyanik

  University of Wisconsin–Madison

  55 shared

• Kran Suknuntha

  Ramathibodi Hospital

  38 shared

• Thomas R. Jerrells

  33 shared

• Akhilesh Kumar

  Fortis Escorts Heart Institute

  30 shared

• James Thomson

  29 shared

• Ron Stewart

  Morgridge Institute for Research

  26 shared

• Thaddeus G. Golos

  University of Wisconsin–Madison

  24 shared

Education

• M.D.

  University of Wisconsin School of Medicine and Public Health

• Ph.D.

  University of Wisconsin School of Medicine and Public Health

Awards & honors

• The Henry Pitot Professor in Pathology and Laboratory Medici…

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