Hydar Ali

About

Hydar Ali, Ph.D., is a faculty member in the Biomedical Graduate Studies at the Perelman School of Medicine, University of Pennsylvania. His research focuses on utilizing pre-clinical humanized mouse models to investigate how novel G Protein Coupled Receptor (GPCR) signaling in mast cells influences neurogenic inflammation and immune-mediated disorders. His lab aims to delineate the mechanisms by which biased signaling through GPCRs, particularly MRGPRX2, contributes to innate immunity, host defense, and various inflammatory conditions such as anaphylaxis, drug hypersensitivity, neurogenic inflammation, asthma, skin inflammation, ulcerative colitis, and periodontitis. Dr. Ali's work involves developing humanized mouse models to study receptor mutations and expression modulation, advancing understanding of mast cell activation and its role in allergic and inflammatory diseases. His contributions include identifying the role of MRGPRX2 in mast cell activation, developing antagonists, and exploring its implications in diseases, with a particular emphasis on biased signaling pathways and their therapeutic potential.

Research topics

• Biology
• Cell biology
• Chemistry
• Immunology
• Biochemistry

Selected publications

• Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease

  Journal of Allergy and Clinical Immunology · 2021-05-03 · 161 citations

  reviewOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

  Current Allergy and Asthma Reports · 2021-01-01 · 86 citations

  reviewOpen accessSenior author
  PublisherOA PDFDOI

• MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

  Journal of Investigative Dermatology · 2020-10-12 · 55 citations

  articleOpen access
  PublisherOA PDFDOI

• Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

  International Journal of Molecular Sciences · 2021-05-18 · 41 citations

  articleOpen accessSenior authorCorresponding

  The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain MRGPRX2 agonists activate an additional signaling pathway that involves the recruitment of β-arrestins, which contributes to receptor internalization and desensitization (balanced agonists). We found that SP cause…

  PublisherOA PDFDOI

• Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

  Frontiers in Immunology · 2022-10-06 · 40 citations

  articleOpen accessSenior authorCorresponding

  Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs) contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) approved drugs such as the neuromuscular blocking agent, rocuronium. In addition, activation of MRGPRX2 by the neuropeptide substance P (SP) and the pro-adrenomedullin peptide (PAMP-12) is associated with a variety of cutaneous conditions such as neurogenic inflammation, pain, atopic dermatitis, urticaria, and itch. Thus, sm…

  PublisherOA PDFDOI

Recent grants

• Roles of novel MRGPRX2/MrgprB2 signaling in mast cells on host defense and Inflammation

  NIH · $3.9M · 2019–2030

• NIH Grant R29HL054166

  NIH · $547k · 2001

• NIH Grant R01HL063372

  NIH · $1.1M · 2006

Frequent coauthors

• Ralph Snyderman

  Duke University

  50 shared

• Bodduluri Haribabu

  University of Louisville

  47 shared

• Ricardo M. Richardson

  North Carolina Central University

  34 shared

• Michael A. Beaven

  National Heart Lung and Blood Institute

  25 shared

• Hariharan Subramanian

  University Medical Center Hamburg-Eppendorf

  17 shared

• Saptarshi Roy

  Virginia Commonwealth University

  16 shared

• Alastair J. Barr

  University of Westminster

  13 shared

• Kshitij Gupta

  13 shared

Labs

• Hydar Ali LabPI

Education

• Ph.D., Chemistry

  University College London

  1986

Similar researchers at University of Pennsylvania

• Michael J. Mayh-60
• Michael L. Atchisonh-39
• Nicola J Masonh-33