About

Henry A. Ferreyra is a Clinical Professor of Ophthalmology at UC San Diego School of Medicine, located in La Jolla, CA. He completed his undergraduate studies at UC Berkeley with a BA in Molecular and Cell Biology in December 1993. He earned his MD from UC San Diego School of Medicine in June 2000, followed by a General Surgery Internship at UC San Francisco in 2001. His residency in Ophthalmology was completed at UC San Diego in June 2007, and he further specialized with a Vitreoretinal Fellowship at the Kellogg Eye Center, University of Michigan, in October 2007. His research focuses on various aspects of ophthalmology, including inherited retinal degenerations, macular diseases, and retinal imaging, with numerous publications in these fields.

Research topics

• Medicine
• Ophthalmology
• Computational biology
• Genetics
• Biology
• Pathology
• Internal medicine

Selected publications

• Faricimab for treatment-resistant choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD): seven-months results using artificial intelligence and OCTA

  International Journal of Retina and Vitreous · 2025-06-17 · 8 citations

  articleOpen access

  BACKGROUND: To analyze the therapeutic response to faricimab 6 mg/0.05 ml in eyes with neovascular AMD (nAMD) with refractory intra- and/or subretinal fluid due to choroidal neovascularization (CNV), previously unresponsive to 4 mg monthly aflibercept and combination therapy with anti-VEGF and long-acting steroids. METHODS: A retrospective case series study of 22 eyes with unresponsive CNV, despite monthly intravitreal treatment (mean number of pre-faricimab injections: 35.52 ± 17.12). We evaluated therapeutic response in eyes with persistent intra/subretinal fluid (IRF/SRF) unresponsive to anti-VEGF double-dose (DD) monotherapy (4-mg aflibercept) and/or simultaneous DD anti-VEGF (4-mg aflibercept) with steroids (triamcinolone). Best-corrected visual acuity (BCVA), intraocular pressure (IOP), and optical coherence tomography (OCT) measurements of central retinal thickness (CRT) were recorded for 7 follow-ups. Baseline and follow-up OCTs were examined by an AI-developed platform (Discovery OCT Fluid and Biomarker Detector, RetinAI AG, Switzerland) to measure the volume of IRF, SRF, and pigment epithelium detachment (PED) in nanoliters (nL) and CRT in micrometers (μm). Paired t-test compared these parameters at baseline and after treatment. OCTA analysis of CNV before and after treatment with faricimab was conducted using Angio-Tool software. RESULTS: Anatomic outcomes included mean CRT reduction of -25.3 μm (p = 0.0118) at month-1, -16.15 μm (p = 0.0414) at month-4, and -26.36 μm (p = 0.0129) after the 7th follow-up. AI-assisted software analysis showed a significant reduction of IRF, SRF, and PED volume at multiple time points after initiating faricimab. There was a non-significant improvement in BCVA. CONCLUSIONS: Switching to faricimab improved anatomy in highly treatment-resistant CNV eyes, indicating its potential when other therapeutic options have failed.

  PublisherOA PDFDOI

• Evaluating the clinical utility of multimodal large language models in rare maculopathy

  Scientific Reports · 2025-12-03

  articleOpen access

  This study aimed to assess how multimodal large language models (MLLM) diagnose and differentiate Pentosan Polysulfate (PPS) Maculopathy from other phenotypic mimics. A retrospective review of clinical records and multimodal retinal imaging was conducted with patients from the Shiley Eye Institute and Casey Eye Institute. Four MLLMs (ChatGPT-4o, Claude 3.5 Sonnet, Google Gemini 1.5 Pro, Perplexity Llama 3.1 Sonar/Default) along with human retinal specialists answered prompts based on retinal imaging and demographic data. Performance was evaluated using accuracy, sensitivity and specificity estimates. The study included 126 eyes from 63 patients, with 36 eyes with PPS maculopathy, 50 eyes with Stargardt disease, and 40 eyes with PRPH2-associated multifocal pattern dystrophy. MLLMs showed improved accuracy and sensitivity when answer choices were restricted, with ChatGPT consistently performing best when all imaging modalities were prompted together. The inclusion of demographic data further enhanced performance in prompts with limited answer choices. Human retinal specialist evaluations aligned with MLLM performance trends and also improved with demographic data. While MLLMs show diagnostic potential, further refinement is needed before clinical implementation. These findings highlight the importance of prompt design and demographic data to optimize MLLM performance with retinal imaging modalities.

  PublisherOA PDFDOI

• Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries

  Nature Genetics · 2024-12-01 · 35 citations

  articleOpen access
  PublisherOA PDFDOI

• Atypical choroidal neovascular membrane

  American Journal of Ophthalmology Case Reports · 2024-10-05 · 1 citations

  articleOpen access

  Purpose: To report the course of atypical choroidal neovascularization (CNV) in a middle-aged woman experiencing sudden vision loss. Observations: A middle-aged female presented with sudden onset vision loss. Following in depth investigations an initial diagnosis of presumed idiopathic CNV was made in her right eye. Multimodal imaging confirmed the presence of CNV, while the left eye remained unaffected. The CNV initially responded well to intravitreal Aflibercept injections, resulting in significant visual improvement. However, the patient later developed punctate inner choroidopathy (PIC), which eventually responded to systemic but not local corticosteroids. Recurrent CNV became incompletely controlled by Aflibercept. Switching to Faricimab resulted in sustained visual acuity improvement and CNV resolution. Conclusions and Importance: The therapeutic efficacy of anti-VEGF treatments has long been underscored in the management of CNV. However, CNV in younger patients often points to a different causation and sometimes requires different management. Our case underscores the significance of inflammatory causes of CNV and including anti-inflammatories in the treatment of CNV management and outlines differences in anti-VEGF efficacy in control of CNV.

  PublisherDOI

• RETINAL STRUCTURAL CHANGES AFTER CESSATION OF PENTOSAN POLYSULFATE SODIUM

  Retina · 2024-07-05 · 4 citations

  article

  PURPOSE: To quantify baseline and longitudinal structural changes post-cessation in patients with pentosan polysulfate sodium retinopathy. METHODS: This is a retrospective cohort study. Retinal thickness and volume of choroidal and hyperreflective retinal pigment epithelium excrescences were manually segmented from optical coherence tomography volume scans. Baseline measurements were compared against age-matched control subjects. Longitudinal measurements were performed on patients with follow-up data. RESULTS: Twenty-four eyes of 13 patients were included. At baseline, the mean total retinal thickness was lower in the pentosan polysulfate sodium retinopathy cohort than in age- and sex-matched control subjects (269.1 µ m vs. 290.2 µ m, P = 0.006). The median (range) of follow-up was 18.6 (4.1-34.7) months, with the mean last follow-up of 35.2 months after cessation. During the follow-up period, the thickness of the retina decreased significantly by 11.3 µ m (CI: 16.8, 5.8) ( P < 0.001), with an annual mean decrease of 6.70 µ m. However, the mean hyperreflective retinal pigment epithelium excrescence volume did not change significantly ( P = 0.140) over the follow-up period. CONCLUSION: After pentosan polysulfate sodium discontinuation, although retinal pigment epithelium excrescence volume do not change significantly, there continues to be a progressive long-term thinning of the retina, which continues at a rate greater than that associated with normal aging. Consequently, long-term follow-up is suggested to monitor patients with pentosan polysulfate sodium retinopathy.

  PublisherDOI

• Microperimetry Findings in Pentosan Polysulfate Maculopathy

  Ophthalmology Retina · 2023-08-22 · 4 citations

  article
  PublisherDOI

• The Sensitivity of Ultra-Widefield Fundus Photography Versus Scleral Depressed Examination for Detection of Retinal Horseshoe Tears

  American Journal of Ophthalmology · 2023-07-17 · 16 citations

  articleOpen access

  PURPOSE: Ultra-widefield (UWF) imaging is commonly used in ophthalmology in tandem with scleral depressed examinations (SDE) to evaluate peripheral retinal disease. Because of the increased reliance on this technology in tele-ophthalmology, it is critical to evaluate its efficacy for detecting the peripheral retina when performed in isolation. Therefore, we sought to evaluate UWF imaging sensitivity in detecting retinal horseshoe tears (HSTs). STUDY DESIGN: Retrospective clinical validity and reliability study. METHODS: A single-institutional retrospective analysis was performed on patients at the Shiley Eye Institute, University of California, San Diego. Patients with HSTs seen on SDE who underwent treatment with laser were included in the study. A total of 140 patients with HSTs in the right and/or left eyes met the inclusion criteria. Those with concomitant ruptured globes, retinal detachments, and vitreous hemorrhages were excluded. A total of 123 patients with 135 HSTs were included in the final analysis. The primary outcome was the number of HSTs detected by UWF imaging. A secondary outcome was HST location. Sensitivity was measured with respect to HST location, and statistical significance was calculated by Fisher exact testing. RESULTS: A total of 69 (51.1%) HSTs were visualized on UWF images and 66 (48.9%) were not visualized. The sensitivity of UWF imaging in capturing HSTs was 7 of 41 (17.1%), 8 of 25 (32.0%), 7 of 14 (50.0%), and 47 of 55 (85.5%) for the superior, inferior, nasal, and temporal quadrants, respectively. Sensitivities between HST visibility and location were statistically significant (P < .001). CONCLUSIONS: Nearly half of HSTs were missed by UWF imaging. This study demonstrates that UWF imaging alone is not sufficiently sensitive to exclude the presence of HSTs.

  PublisherOA PDFDOI

• PENTOSAN POLYSULFATE SODIUM (ELMIRON) MACULOPATHY

  Retina · 2023-03-30 · 4 citations

  articleCorresponding

  PURPOSE: To assess genetic associations for pentosan polysufate sodium maculopathy. METHODS: Genetic testing for inherited retinal dystrophy genes using exome testing and for 14 age-related macular degeneration-associated single nucleotide polymorphisms (SNPs) using panel testing were performed. In addition, full-field electroretinograms (ffERG) were obtained to identify any cone-rod dystrophy. RESULTS: Eleven of 15 patients were women, with a mean age of 69 (range 46-85). Inherited retinal dystrophy exome testing in five patients revealed six pathogenic variants, but failed to confirm inherited retinal dystrophy in any patient genetically. FfERG performed in 12 patients demonstrated only nonspecific a- and b-wave abnormalities in 11 cases and was normal in one case. For age-related macular degeneration single nucleotide polymorphisms, CFH rs3766405 ( P = 0.003) and CETP ( P = 0.027) were found to be statistically significantly associated with pentosan polysulfate maculopathy phenotype compared with the control population. CONCLUSION: Pentosan polysulfate maculopathy is not associated with Mendelian inherited retinal dystrophy genes. However, several age-related macular degeneration risk alleles were identified to be associated with maculopathy compared with their frequency in the normal population. This suggests a role for genes in disease pathology, particularly the alternative complement pathway. These findings would benefit from further investigation to understand the risk of developing maculopathy in taking pentosan polysulfate.

  PublisherDOI

• Investigating the associations of macular edema in retinitis pigmentosa

  Scientific Reports · 2023-08-30 · 9 citations

  articleOpen access

  Macular edema (ME), the accumulation of intraretinal fluid in the macula, is a common sight affecting sequelae of retinitis pigmentosa (RP). However, it is unclear why some patients develop ME, and others do not. This study aims to identify associations between clinical-genetic factors in RP with ME. Patients with clinically confirmed RP cases were identified from the inherited retinal disease database at a large tertiary referral academic center. Demographic and genetic testing findings were noted. Additionally, optical coherence tomography volume scans were graded using a validated grading system. One hundred and six patients (73.1%) were found to have ME in at least one eye (OD = 88, mean = 37.9%, OS = 98, mean = 31.7%). Structurally, the presence of epiretinal membrane (ERM) (p < 0.007) and vitreo-macular traction (VMT) (p < 0.003) were significantly associated with ME. Additionally, X-linked (p < 0.032) and autosomal dominant inheritance (p < 0.039) demonstrated a significant association with ME, with RP1 (p < 0.045) and EYS (p < 0.017) pathogenic variants also significantly associated with ME. This study, in a large cohort of RP patients, confirms previous retinal structural associations for ME in RP and identifies potential new genetic associations.

  PublisherOA PDFDOI

• Detection of Nonglaucomatous Macula Findings With Ganglion Cell Analysis Printouts vs Full Macular Cube Scans

  JAMA Ophthalmology · 2022-09-08 · 1 citations

  articleOpen access

  Importance: Ganglion cell analysis (GCA) of ocular coherence tomography (OCT) imaging is routinely used to detect and monitor glaucomatous damage of the ganglion cell complex in the macula. The GCA printout provides qualitative and quantitative data about the macular ganglion cell-inner plexiform layer and a single B-scan of the retina through the fovea. However, the full macular cube scan, including all 128 B-scans, is available for review. The macular cube scan provides considerable information about nonglaucomatous ocular pathology that may be missed if clinicians review only the GCA printout. Objective: To determine the frequency and type of nonglaucomatous macular findings that are observable in the full macular cube scan but not the GCA printout. Design, Setting, and Participants: A retrospective cross-sectional analysis of GCA printouts and full macular cube scans to detect nonglaucomatous macular pathology at a tertiary care academic center. Consecutive patients undergoing ganglion cell complex imaging during routine glaucoma evaluations over a 1-week period in a multi-clinician glaucoma clinic. Main Outcomes and Measures: The prevalence and type of nonglaucomatous macular pathology visible on the GCA printout or macular cube scan. Results: Among 105 patients (mean (SD) age, 67 (15.46) years; 63 [60%] female and 42 [40%] male) 201 eyes were imaged (64 [31.7%] with suspected glaucoma, 126 [62.4%] with open-angle glaucoma, 6 [3.0%] with closed-angle glaucoma, and 6 [3.0%] with other glaucoma). GCA printouts and macular cube scans revealed nonglaucomatous macular pathology in 65 eyes (32.2%). Of these, 25 eyes (38.5%) included findings that were not visible on the GCA printout. Of the cases not visible on the printout, 16 eyes (64.0% ) included macular pathology that required further evaluation. Conclusions and Relevance: The findings indicate that nonglaucomatous macular pathology may be missed based on GCA printouts alone. While it may be beneficial to review the full macular cube to detect potentially vision-threatening disease and ensure proper patient care, this study cannot determine if this missed pathology affects clinical outcomes.

  PublisherDOI

Frequent coauthors

• William R. Freeman

  Jacobs (United States)

  35 shared

• Shyamanga Borooah

  Jacobs (United States)

  29 shared

• Eric Nudleman

  29 shared

• Emily Y. Chew

  National Eye Institute

  26 shared

• Kang Zhang

  Southern Medical University

  26 shared

• Dirk‐Uwe Bartsch

  Jacobs (United States)

  21 shared

• Kevin C. Chen

  Vantage View (United States)

  20 shared

• Daniel L. Chao

  Janssen (United States)

  18 shared

Education

• M.D., Ophthalmology

  University of California, San Diego

  1996

• B.S., Biology

  University of California, San Diego

  1992