Haim H. Bau
· Richard H. & S. L. Gabel Professor of Mechanical EngineeringUniversity of Pennsylvania · Aerospace Engineering and Engineering Mechanics
Active 1966–2025
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About
Professor Haim H. Bau is a principal investigator in the field of Micro and Nano Fluidics at the University of Pennsylvania. The webpage indicates his association with the department and his role as a leading researcher in this specialized area. The page also lists his colleagues, students, and research personnel, highlighting his active involvement in guiding research and academic activities within this domain. No additional biographical details, research focus, or background information are provided on the page.
Research topics
- Virology
- Biology
- Pathology
- Medicine
- Genetics
- Molecular biology
- Computer Science
- Immunology
- Chemistry
- Bioinformatics
Selected publications
2020 · 153 citations
The 2019 novel coronavirus (COVID-19) is a newly emerged strain that has never been found in humans before. At present, the laboratory-based reverse transcription-polymerase chain reaction (RT-PCR) is the main method to confirm COVID-19 infection. The intensification of the COVID-19 epidemic overwhelms limited clinical resources in particular, but not only, in developing countries, resulting in many patients not being tested for the infection and in large queues of potentially infected individua…
Nucleic Acids Research · 2019-12-03 · 144 citations
articleOpen accessSenior authorCorrespondingDetection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with abundant wild-type nucleic acids. We describe a novel approach, dubbed NAVIGATER, for increasing the fractions of Nucleic Acids of clinical interest Via DNA-Guided Argonaute from Thermus thermophilus (TtAgo). TtAgo cleaves specifically guide-compl…
Single- and Two-Stage, Closed-Tube, Point-of-Care, Molecular Detection of SARS-CoV-2
Analytical Chemistry · 2021 · 62 citations
Senior authorCorrespondingShort of a vaccine, frequent and rapid testing, preferably at home, is the most effective strategy to contain the COVID-19 pandemic. Herein, we report on single-stage and two-stage molecular diagnostic tests that can be carried out with simple or no instrumentation. Our single-stage amplification is reverse transcription-loop mediated isothermal amplification (RT-LAMP) with custom-designed primers targeting the ORF1ab and the N gene regions of the virus genome. Our new two-stage amplification, d…
2020 · 54 citations
<p>The 2019 novel coronavirus (COVID-19) is a newly emerged strain that has never been found in humans before. At present, the laboratory-based reverse transcription-polymerase chain reaction (RT-PCR) is the main method to confirm COVID-19 infection. The intensification of the COVID-19 epidemic overwhelms limited clinical resources in particular, but not only, in developing countries, resulting in many patients not being tested for the infection and in large queues of potentially infected…
Lab on a Chip · 2021-01-01 · 48 citations
articleOpen accessSenior authorThe porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) are emerging/reemerging coronaviruses (CoVs) of neonatal pigs that cause great economic losses to pig farms and pork processors. Specific, rapid, and simple multiplex detection of these viruses is critical to enable prompt implementation of appropriate control measures. Conventional methods for molecular diagnosis require skilled personnel and relatively sophisticated equi…
Recent grants
Multiplexed point-of-care molecular detection for multiple infections in co-endemic settings
NIH · $443k · 2017–2021
NIH · $443k · 2019
GOALI: Real Time, Nanoscale Imaging of Electrochemistry and Electroplating in Liquid Media
NSF · $282k · 2011–2014
Frequent coauthors
- 73 shared
Michael G. Mauk
University of Pennsylvania
- 40 shared
David M. Raizen
University of Pennsylvania
- 39 shared
Changchun Liu
UConn Health
- 39 shared
Jinzhao Song
- 39 shared
Jinzhou Yuan
Research Institute of Dallas
- 31 shared
Mohamed El‐Tholoth
Higher Colleges of Technology
- 26 shared
Joseph M. Grogan
Griffith University
- 21 shared
Howard H. Hu
Labs
Education
- 1989
Ph.D., Mechanical Engineering
University of California, Berkeley
- 1985
M.S., Mechanical Engineering
University of California, Berkeley
- 1983
B.S., Mechanical Engineering
University of California, Berkeley
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