Guosong Hong

About

Guosong Hong is an Assistant Professor of Materials Science and Engineering at Stanford University. His research integrates materials science, physics, and chemistry to address fundamental challenges in biology and medicine. The Hong Lab is internationally recognized for pioneering technologies in in vivo optical transparency, deep-tissue light delivery, and biophotonics-enabled neurotechnology. In 2024, the Hong Lab reported the world’s first live transparent mice in Science, demonstrating that optical transparency in living animals can be achieved transiently and reversibly through materials-based control of light-tissue interactions. This discovery has since catalyzed a wave of follow-up studies worldwide, enabling new approaches to deep-tissue imaging, neural modulation, and light-based therapeutic applications. Dr. Hong’s contributions have been recognized with several major honors, including the Presidential Early Career Award for Scientists and Engineers (PECASE), the Vilcek Prize for Creative Promise in Biomedical Science, the Sloan Research Fellowship in Physics, and the Walter J. Gores Award for Excellence in Teaching.

Research topics

• Nanotechnology
• Materials science
• Chemistry
• Optoelectronics
• Biology
• Anatomy
• Internal medicine
• Organic chemistry
• Neuroscience
• Physics

Selected publications

• Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window

  Nature Biomedical Engineering · 2022 · 216 citations

  Senior authorCorresponding
  DOI

• Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

  Nano-Micro Letters · 2021 · 116 citations

  Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment. Herein, we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the "precise strike" of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid (HA) and hypoxia-dependent factor carbonic anhydrase IX (CA IX)-inhibitor acetazolamide (AZ). The core of nanobullets is the special zinc (II) phthalocyanine aggregates (ZPA) whi…

  DOI

• Sub-10-nm graphene nanoribbons with atomically smooth edges from squashed carbon nanotubes

  Nature Electronics · 2021 · 105 citations

  DOI

• Thermal Processing Creates Water‐Stable PEDOT:PSS Films for Bioelectronics

  Advanced Materials · 2025-03-03 · 39 citations

  articleOpen access

  Organic mixed ionic-electronic conductors have emerged as a key material for the development of bioelectronic devices due to their soft mechanical properties, biocompatibility, and high volumetric capacitance. In particular, PEDOT:PSS has become a choice material because it is highly conductive, easily processible, and commercially available. However, PEDOT:PSS is dispersible in water, leading to delamination of films when exposed to biological environments. For this reason, chemical cross-linki…

  PublisherOA PDFDOI

• Aging-dependent evolving electrochemical potentials of biomolecular condensates regulate their physicochemical activities

  Nature Chemistry · 2025-03-12 · 32 citations

  articleCorresponding
  PublisherDOI

Recent grants

• Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable Electronics

  NIH · $128k · 2017–2018

• EAGER: Neuromodulation in the second near-infrared window

  NSF · $300k · 2022–2024

• Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable Electronics

  NIH · $128k · 2017–2019

Frequent coauthors

• Xiang Wu

  Stanford University

  61 shared

• Nicholas J. Rommelfanger

  Neurosciences Institute

  57 shared

• Limin Qi

  Peking University

  54 shared

• Hongjie Dai

  Southwest University

  50 shared

• Alexander L. Antaris

  Intuitive Surgical (United States)

  34 shared

• Fan Yang

  Stanford University

  34 shared

• Zihao Ou

  Stanford University

  33 shared

• Shuo Diao

  Southwest University

  32 shared

Education

• Ph.D., Materials Science and Engineering

  Stanford University

  2014

• M.S., Materials Science and Engineering

  University of California, Berkeley

  2009

• B.S., Materials Science and Engineering

  University of Science and Technology of China

  2007

Awards & honors

• Presidential Early Career Award for Scientists and Engineers…
• Vilcek Prize for Creative Promise in Biomedical Science
• Sloan Research Fellowship in Physics
• Walter J.. Gores Award for Excellence in Teaching

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