Guangying Chen

· Assistant Professor of Marketing

University of Southern California · Marketing

Active 2005–2023

h-index35

Citations4.9k

Papers786 last 5y

Funding$1.5M

Faculty page Website

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About

My research primarily focuses on two areas. The first examines the interactions between recommender systems and social media user behavior—specifically content consumption, production, and privacy protection—using field experiments and structural models. The second applies statistical and machine learning approaches to develop novel causal inference methods addressing identification challenges in business research, such as instrumental variable estimation in randomized encouragement designs when the exclusion restriction is violated.

Research topics

Physics
Chemistry
Bioinformatics
Astrophysics
Oncology
Medicine
Genetics
Radiochemistry
Organic chemistry
Astrobiology
Biology
Physical chemistry
Atomic physics
Internal medicine
Quantum mechanics

Selected publications

Data from Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos
2023-03-31
preprintOpen access
<div>AbstractBackground: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos.Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10−4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894).Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10−6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I: OR = 1.45; P = 7.01 × 10−5 and stage II: OR = 1.58; P = 3.05 × 10−7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10−25 and OR = 1.07; P = 1.02 × 10−16 for Japanese and Latinos, respectively).Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev; 21(11); 2048–58. ©2012 AACR.</div>
Publisher DOI
Supplementary Table 1 from Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos
2023-03-31
supplementary-materialsOpen access
PDF file, 204K, Quantile-quantile plots of test comparison for genotype frequencies in cases vs controls.
Publisher OA PDF DOI
Data from Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos
2023-03-31
preprintOpen access
<div>AbstractBackground: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos.Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10−4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894).Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10−6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I: OR = 1.45; P = 7.01 × 10−5 and stage II: OR = 1.58; P = 3.05 × 10−7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10−25 and OR = 1.07; P = 1.02 × 10−16 for Japanese and Latinos, respectively).Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev; 21(11); 2048–58. ©2012 AACR.</div>
Publisher DOI
Supplementary Table 1 from Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos
2023-03-31
supplementary-materialsOpen access
PDF file, 204K, Quantile-quantile plots of test comparison for genotype frequencies in cases vs controls.
Publisher DOI
Stochastic Epigenetic Mutations Influence Parkinson’s Disease Risk, Progression, and Mortality
Journal of Parkinson s Disease · 2021 · 14 citations
1st authorCorresponding
- Oncology
- Medicine
- Internal medicine
BACKGROUND: Stochastic epigenetic mutations (SEM) reflect a deviation from normal site-specific methylation patterns. Epigenetic mutation load (EML) captures the accumulation of SEMs across an individual's genome and may reflect dysfunction of the epigenetic maintenance system in response to epigenetic challenges. OBJECTIVE: We investigate whether EML is associated with PD risk and time to events (i.e., death and motor symptom decline). METHODS: We employed logistic regression and Cox proportional hazards regression to assess the association between EML and several outcomes. Our analyses are based on 568 PD patients and 238 controls from the Parkinson's disease, Environment and Genes (PEG) study, for whom blood-based methylation data was available. RESULTS: We found an association for PD onset and EML in all genes (OR = 1.90; 95%CI 1.52-2.37) and PD-related genes (OR = 1.87; 95%CI 1.50-2.32). EML was also associated with time to a minimum score of 35 points on the motor UPDRS exam (OR = 1.28; 95%CI 1.06-1.56) and time to death (OR = 1.29, 95%CI 1.11-1.49). An analysis of PD related genes only revealed five intragenic hotspots of high SEM density associated with PD risk. CONCLUSION: Our findings suggest an enrichment of methylation dysregulation in PD patients in general and specifically in five PD related genes. EML may also be associated with time to death and motor symptom progression in PD patients.
Publisher OA PDF DOI
The Potential for Enhancing the Power of Genetic Association Studies in African Americans through the Reuse of Existing Genotype Data
UNC Libraries · 2021-06-24
articleOpen access
We consider the feasibility of reusing existing control data obtained in genetic association studies in order to reduce costs for new studies. We discuss controlling for the population differences between cases and controls that are implicit in studies utilizing external control data. We give theoretical calculations of the statistical power of a test due to Bourgain et al (Am J Human Genet 2003), applied to the problem of dealing with case-control differences in genetic ancestry related to population isolation or population admixture. Theoretical results show that there may exist bounds for the non-centrality parameter for a test of association that places limits on study power even if sample sizes can grow arbitrarily large. We apply this method to data from a multi-center, geographically-diverse, genome-wide association study of breast cancer in African-American women. Our analysis of these data shows that admixture proportions differ by center with the average fraction of European admixture ranging from approximately 20% for participants from study sites in the Eastern United States to 25% for participants from West Coast sites. However, these differences in average admixture fraction between sites are largely counterbalanced by considerable diversity in individual admixture proportion within each study site. Our results suggest that statistical correction for admixture differences is feasible for future studies of African-Americans, utilizing the existing controls from the African-American Breast Cancer study, even if case ascertainment for the future studies is not balanced over the same centers or regions that supplied the controls for the current study.
Publisher DOI
Isomer-specific kinetics of the C + + H 2 O reaction at the temperature of interstellar clouds
Science Advances · 2021 · 29 citations
- Astrobiology
- Chemistry
- Physics
followed by isomerization of products with internal energy over the isomerization barrier.
Publisher DOI
Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry
UNC Libraries · 2021-06-24
articleOpen access
Adult height is a classic polygenic trait of high heritability (h 2 ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10−12 and 2p14-rs4315565, P = 1.2×10−8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10−4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits.
Publisher DOI
Determining reaction pathways at low temperatures by isotopic substitution: the case of BeD + + H2O
New Journal of Physics · 2021 · 5 citations
- Physics
- Atomic physics
- Chemistry
Trapped Be+ ions are a leading platform for quantum information science (Gaebler et al 2016 Phys. Rev. Lett. 117 060505), but reactions with background gas species, such as H2 and H2O, result in qubit loss. Our experiment reveals that the BeOH+ ion is the final trapped ion species when both H2 and H2O exist in a vacuum system with cold, trapped Be+. The BeH+ product in the Be+ + H2 reaction further reacts with H2O to form BeOH+. To understand the loss mechanism, low-temperature reactions between sympathetically cooled BeD+ ions and H2O molecules have been investigated using an integrated, laser-cooled Be+ ion trap and high-resolution time-of-flight mass spectrometer (Schneider et al 2014 Phys. Rev. Appl. 2 034013). Among all the possible products, BeH2O+, H2DO+, BeOD+, and BeOH+, only the BeOH+ molecular ion was observed experimentally, with the assumed co-product of HD. Theoretical analyses based on explicitly correlated restricted coupled cluster singles, doubles, and perturbative triples (RCCSD(T)-F12) method with the augmented correlation-consistent polarized triple zeta (AVTZ) basis set reveal that two intuitive direct abstraction product channels, Be + H2DO+ and D + BeH2O+, are not energetically accessible at the present reaction temperature (∼150 K). Instead, a double displacement BeOH+ + HD product channel is accessible due to a large exothermicity of 1.885 eV through a submerged barrier in the reaction pathway. While the BeOD+ + H2 product channel has a similar exothermicity, the reaction pathway is dynamically unfavourable, as suggested by a sudden vector projection analysis. This work sheds light on the origin of the loss and contaminations of the laser-cooled Be+ ions in quantum-information experiments.
Publisher OA PDF DOI
Determining Reaction Pathways at Low Temperatures by Isotopic Substitution: The Case of BeD+ + H2O
arXiv (Cornell University) · 2021-08-11
preprintOpen access
Trapped Be+ ions are a leading platform for quantum information science [1], but reactions with background gas species, such as H2 and H2O, result in qubit loss. Our experiment reveals that the BeOH+ ion is the final trapped ion species when both H2 and H2O exist in a vacuum system with cold, trapped Be+. To understand the loss mechanism, low-temperature reactions between sympathetically cooled BeD+ ions and H2O molecules have been investigated using an integrated, laser-cooled Be+ ion trap and high-resolution Time-of-Flight (TOF) mass spectrometer (MS) [2]. Among all the possible products,BeH2O+, H2DO+, BeOD+, and BeOH+, only the BeOH+ molecular ion was observed experimentally, with the assumed co-product of HD. Theoretical analyses based on explicitly correlated restricted coupled cluster singles, doubles, and perturbative triples (RCCSD(T)-F12) method with the augmented correlation-consistent polarized triple zeta (AVTZ) basis set reveal that two intuitive direct abstraction product channels, Be + H2DO+ and D + BeH2O+, are not energetically accessible at the present reaction temperature (~150 K). Instead, a double displacement BeOH+ + HD product channel is accessible due to a large exothermicity of 1.885 eV through a submerged barrier in the reaction pathway. While the BeOD+ + H2 product channel has a similar exothermicity, the reaction pathway is dynamically unfavourable, as suggested by a Sudden Vector Projection analysis. This work sheds light on the origin of the loss and contaminations of the laser-cooled Be+ ions in quantum-information experiments.
Publisher OA PDF DOI

Recent grants

NIH Grant R01MH100879
NIH · $1.5M · 2017

Frequent coauthors

Loı̈c Le Marchand
Cancer Center of Hawaii
150 shared
Laurence N. Kolonel
110 shared
Brian E. Henderson
108 shared
Christopher A. Haiman
106 shared
Daniel O. Stram
67 shared
Iona Cheng
UCSF Helen Diller Family Comprehensive Cancer Center
60 shared
Kristine R. Monroe
University of Southern California
50 shared
Peggy Wan
50 shared

Education

Ph.D., Marketing
Olin Business School, Washington University in St. Louis
M.A., Economics
Tsinghua University
B.A., Economics
Peking University
B.S., Statistics
Peking University

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