Gina Brown-Guedira

About

Gina Brown-Guedira is a Professor in the Department of Crop and Soil Sciences at NC State University, affiliated with the College of Agriculture and Life Sciences. Her research focuses on plant genetics, with particular emphasis on wheat and other crops, leveraging multi-omics data and machine learning to improve crop yield predictions and resistance traits. She has contributed to the discovery of major QTLs for disease resistance, fine mapping of rust resistance genes, and the development of high-yielding, disease-resistant wheat cultivars adapted to the southeastern United States. Her work aims to enhance crop resilience and productivity through advanced genetic and genomic approaches.

Selected publications

• Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

  Nature Biotechnology · 2021-11-01 · 286 citations

  articleOpen access

  Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern…

  PublisherOA PDFDOI

• Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat

  Nature Communications · 2022-02-11 · 101 citations

  articleOpen access

  Allopolyploidy greatly expands the range of possible regulatory interactions among functionally redundant homoeologous genes. However, connection between the emerging regulatory complexity and expression and phenotypic diversity in polyploid crops remains elusive. Here, we use diverse wheat accessions to map expression quantitative trait loci (eQTL) and evaluate their effects on the population-scale variation in homoeolog expression dosage. The relative contribution of cis- and trans-eQTL to hom…

  PublisherOA PDFDOI

• Updated guidelines for gene nomenclature in wheat

  Theoretical and Applied Genetics · 2023-03-23 · 100 citations

  articleOpen access

  KEY MESSAGE: Here, we provide an updated set of guidelines for naming genes in wheat that has been endorsed by the wheat research community. The last decade has seen a proliferation in genomic resources for wheat, including reference- and pan-genome assemblies with gene annotations, which provide new opportunities to detect, characterise, and describe genes that influence traits of interest. The expansion of genetic information has supported growth of the wheat research community and catalysed s…

  PublisherDOI

• Discovery of a major QTL for resistance to the guava root-knot nematode (Meloidogyne enterolobii) in ‘Tanzania’, an African landrace sweetpotato (Ipomoea batatas)

  Theoretical and Applied Genetics · 2024-09-26 · 5 citations

  articleOpen access

  Sweetpotato, Ipomoea batatas (L.) Lam. (2n = 6x = 90), is among the world's most important food crops and is North Carolina's most important vegetable crop. The recent introduction of Meloidogyne enterolobii poses a significant economic threat to North Carolina's sweetpotato industry and breeding resistance into new varieties has become a high priority for the US sweetpotato industry. Previous studies have shown that 'Tanzania', a released African landrace, is resistant to M. enterolobii. We scr…

  PublisherOA PDFDOI

• Fine mapping of stem rust resistance derived from soft red winter wheat cultivar AGS2000 to an NLR gene cluster on chromosome 6D

  Theoretical and Applied Genetics · 2024-08-19 · 4 citations

  articleOpen accessSenior author

  The Puccinia graminis f. sp. tritici (Pgt) Ug99-emerging virulent races present a major challenge to global wheat production. To meet present and future needs, new sources of resistance must be found. Identification of markers that allow tracking of resistance genes is needed for deployment strategies to combat highly virulent pathogen races. Field evaluation of a DH population located a QTL for stem rust (Sr) resistance, QSr.nc-6D from the breeding line MD01W28-08-11 to the distal region of chr…

  PublisherOA PDFDOI

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