George M. Shaw
University of Pennsylvania · Rehabilitation Medicine
Active 1975–2025
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About
George M. Shaw, M.D., Ph.D., is a Professor of Medicine (Hematology-Oncology) at the University of Pennsylvania and a member of the Abramson Cancer Center and the PENN Center for AIDS Research. His laboratory has a longstanding interest in the molecular biology and immunopathogenesis of human immunodeficiency virus (HIV-1) and hepatitis C virus (HCV). His research has included the first molecular clones of HIV-1, the discovery of the quasispecies nature of HIV-1 in vivo, and the investigation of viral replication dynamics and persistence in vivo. Shaw's work extends to the molecular identification and biological characterization of transmitted/founder HIV-1 genomes, as well as studies on simian immunodeficiency virus (SIV) infection in rhesus macaques and HCV infection in humans. His recent efforts focus on developing novel strategies for constructing SHIV chimeras that replicate efficiently in rhesus macaques and induce broadly neutralizing antibodies, serving as models for HIV-1 vaccine development. His projects aim to elucidate HIV-1 transmission, persistence, and pathogenesis, as well as the development of vaccine strategies and understanding viral-host interactions that underpin immune responses and virus evolution.
Research topics
- Biology
- Immunology
- Virology
- Cell biology
- Computational biology
- Molecular biology
- Computer Science
- Anatomy
- Genetics
- Evolutionary biology
Selected publications
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
Nature reviews. Immunology · 2022 · 346 citations
Senior authorCorrespondingNature Medicine · 2020 · 168 citations
T cells. We propose that cellular immune responses reduce the threshold of nAbs required to confer superior and durable protection.
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
Science · 2020 · 99 citations
Senior authorCorrespondingNeutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertio…
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies
Cell · 2021 · 90 citations
Journal of Virology · 2021 · 43 citations
Senior authorCorrespondingSHIV infection of Indian rhesus macaques is an important animal model for studying HIV-1 transmission, prevention, immunopathogenesis and cure. Such research is timely, given recent progress with active and passive immunization and novel approaches to HIV-1 cure. Given the multifaceted roles of HIV-1 Env in cell tropism and virus entry, and as a target for neutralizing and non-neutralizing antibodies, Envs selected for SHIV construction are of paramount importance. Until recently, it has been im…
Recent grants
NIH · $1.4M · 1997
NIH · $1.1M · 1998
Targeting 5' leader-encoded defective ribosomal products for HIV T cell vaccines
NIH · $3.6M · 2016–2022
Frequent coauthors
- 538 shared
Beatrice H. Hahn
University of Pennsylvania
- 268 shared
Frédéric Bibollet‐Ruche
University of Pennsylvania
- 264 shared
Brandon F. Keele
Frederick National Laboratory for Cancer Research
- 249 shared
Paul M. Sharp
University of Edinburgh
- 214 shared
Martine Peeters
- 192 shared
Yingying Li
University of Pennsylvania
- 191 shared
Elizabeth Bailes
University of Nottingham
- 168 shared
Mario L. Santiago
University of Colorado Anschutz Medical Campus
Labs
Shaw LabPI
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