Gary Schiltz
· Research ProfessorNorthwestern University · Chemistry
Active 2001–2024
Research topics
- Biology
- Cancer research
- Genetics
- Computational biology
- Medicine
- Internal medicine
Selected publications
Going beyond Polycomb: EZH2 functions in prostate cancer
Oncogene · 2021 · 103 citations
- Biology
- Cancer research
- Genetics
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies
Frontiers in Immunology · 2020 · 222 citations
- Medicine
- Computational biology
- Cancer research
study of IDO, we also review current transgenic animal modeling systems while highlighting three new constructs recently created by our group. This work converges on the central premise that maximal immunotherapeutic efficacy in subjects with advanced cancer requires both IDO enzyme- and non-enzyme-neutralization, which is not adequately addressed by available IDO-targeting pharmacologic approaches at this time.
Recent grants
Small molecule CXCR4 modulators as molecular probes for studying AML
NIH · $1.6M · 2015–2018
Discovery of novel small molecule antidepressants
NIH · $1.1M · 2016–2020
IDO1 and Immunotolerance in Glioblastoma
NIH · $4.6M · 2016–2027
Frequent coauthors
- 41 shared
Leonidas C. Platanias
Northwestern University
- 41 shared
Rama K. Mishra
- 36 shared
Derek A. Wainwright
Loyola University Medical Center
- 33 shared
Daniela Matei
University of Medicine and Pharmacy of Craiova
- 31 shared
Craig Horbinski
Northwestern University
- 29 shared
Kristen L. Lauing
- 28 shared
Rimas V. Lukas
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- 28 shared
Lijie Zhai
University of Science and Technology Beijing
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