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Francisco J. Diaz

· Associate Professor of Reproductive Biology

Pennsylvania State University · Animal Sciences

Active 1971–2025

h-index26
Citations2.6k
Papers10314 last 5y
Funding$322k

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Francisco J. Diaz is an Associate Professor of Reproductive Biology at the Pennsylvania State University Department of Animal Science. His research focuses on reproductive biology, contributing to the understanding of animal reproductive processes. As a faculty member, he is involved in advancing the sciences related to animal reproduction, supporting education and research within the department.

Research topics

  • Genetics
  • Biology
  • Internal medicine
  • Cell biology
  • Chemistry
  • Endocrinology
  • Andrology
  • Neuroscience
  • Ecology

Selected publications

  • Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

    PLoS Biology · 2020 · 150 citations

    Mutations create genetic variation for other evolutionary forces to operate on and cause numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly understood. Progress in the area is hindered by the fact that error rates of conventional sequencing technologies (1 in 100 or 1,000 base pairs) are several orders of magnitude higher than de novo mutation rates (1 in 10,000,000 or 100,000,000 base pairs per generation). Moreover, previous analyses of germline de novo mutatio…

    PublisherOA PDFDOI

  • Role of zinc in female reproduction

    Biology of Reproduction · 2021 · 109 citations

    Senior authorCorresponding

    Zinc is a critical component in a number of conserved processes that regulate female germ cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular concentration of zinc in the oocyte maintains meiotic arrest at prophase I until the germ cell is ready to undergo maturation. An adequate supply of zinc is necessary for the oocyte to form a fertilization-competent egg as dietary zinc deficiency or chelation of zinc disrupts maturation and reduces the oocyte qual…

    PublisherOA PDFDOI

  • Ovulatory signals alter granulosa cell behavior through YAP1 signaling

    Reproductive Biology and Endocrinology · 2019-12-01 · 68 citations

    articleOpen accessSenior authorCorresponding

    BACKGROUND: The Hippo pathway plays critical roles in regulating cell proliferation, differentiation and survival among species. Hippo pathway proteins are expressed in the ovary and are involved in ovarian function. Deletion of Lats1 causes germ cell loss, ovarian stromal tumors and reduced fertility. Ovarian fragmentation induces nuclear YAP1 accumulation and increased follicular development. At ovulation, follicular cells stop proliferating and terminally differentiate, but the mechanisms con…

    PublisherOA PDFDOI

  • Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues

    Proceedings of the National Academy of Sciences · 2022 · 34 citations

    Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new mtDNA mutations arise and accumulate with age remains understudied because of the high error rates of current sequencing technologies. Duplex sequencing reduces error rates by several orders of magnitude via independently tagging and analyzing each of the two template DNA strands. Here, using duplex sequencing, we obtained high-quality mtDNA sequences for somatic tissues (liver and skeletal muscle) and singl…

    PublisherOA PDFDOI

  • Zinc deficiency reduces fertility in C. elegans hermaphrodites and disrupts oogenesis and meiotic progression

    Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · 2016-09-21 · 24 citations

    articleSenior authorCorresponding
    PublisherDOI

Recent grants

Frequent coauthors

  • S. Guerchicoff

    University of Bern

    16 shared

  • Saúl Drajer

    16 shared

  • H. J. Dengler

    16 shared

  • H. Kunik

    Federal Government of Germany

    16 shared

  • F. Gross

    University of Zurich

    16 shared

  • M Olle

    MVZ - Kurfürstendamm

    16 shared

  • Barry G. Woodcock

    16 shared

  • Larry J. Siegel

    16 shared

Education

  • B.S.

    University of Vermont

    1994

  • M.S.

    University of Wisconsin-Madison

    1999

  • Ph.D.

    University of Wisconsin-Madison

    2003

  • Other

    The Jackson Laboratory

    2007

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