Federica Accornero

About

Federica Accornero is the George D. Eggleston Professor of Biochemistry at Brown University. She serves as Co-Director of Graduate Studies for the Molecular Biology, Cell Biology, and Biochemistry Graduate Program. She earned her PhD from the University of Turin in 2007. Her research focuses on molecular biology, cell biology, and biochemistry, contributing to the understanding of gene expression regulation. She teaches courses including Introduction to Molecular Research in the Life Sciences and Post–Transcriptional Regulations of Gene Expression.

Research topics

• Medicine
• Internal medicine
• Biology
• Cell biology
• Genetics
• Endocrinology
• Cardiology
• Chemistry
• Pathology
• Biochemistry

Selected publications

• YTHDF2 governs muscle size through a targeted modulation of proteostasis

  Nature Communications · 2024-03-11 · 13 citations

  articleOpen accessSenior author

  Abstract The regulation of proteostasis is fundamental for maintenance of muscle mass and function. Activation of the TGF-β pathway drives wasting and premature aging by favoring the proteasomal degradation of structural muscle proteins. Yet, how this critical post-translational mechanism is kept in check to preserve muscle health remains unclear. Here, we reveal the molecular link between the post-transcriptional regulation of m 6 A-modified mRNA and the modulation of SMAD-dependent TGF-β signa…

  PublisherOA PDFDOI

• YTHDF1 is pivotal for maintenance of cardiac homeostasis

  Journal of Molecular and Cellular Cardiology · 2024-05-18 · 13 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• Nanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism

  Circulation · 2024-04-15 · 10 citations

  letterOpen accessSenior author
  PublisherOA PDFDOI

• Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration

  Pharmacology & Therapeutics · 2024-03-26 · 4 citations

  reviewOpen access
  PublisherOA PDFDOI

• The m⁶A-binding protein YTHDF3 modulates the cardiac response to stress

  RNA · 2025-04-11 · 3 citations

  articleOpen accessSenior author

  Transcriptional regulation of gene expression has long been studied; however, only recently has the impact of chemical mRNA modification on protein synthesis emerged. Among posttranscriptional modifications, methylation of the N 6 -adenosine site of mRNA (m 6 A) is very prevalent in eukaryotes and plays a critical role in the heart. To date, the mechanism through which m 6 A controls cardiac function remains elusive. The fate of m 6 A-modified mRNAs is regulated by members of the YTH domain fami…

  PublisherOA PDFDOI

Recent grants

• Post-transcriptional regulation of cardiac hypertrophy

  NIH · $4.7M · 2017–2027

• Mechanistic characterization of a new master regulator of cardiac virus infections

  NIH · $2.3M · 2020–2025

• BEX1 and the control of protein translation in cardiac hypertrophy

  NIH · $727k · 2013–2020

Frequent coauthors

• Jeffery D. Molkentin

  Cincinnati Children's Hospital Medical Center

  97 shared

• John N. Lorenz

  University of Cincinnati

  57 shared

• Jop H. van Berlo

  University of Minnesota Medical Center

  49 shared

• Allen J. York

  Cincinnati Children's Hospital Medical Center

  40 shared

• Izhak Kehat

  Rappaport Family Institute for Research in the Medical Sciences

  29 shared

• Sanjeewa A. Goonasekera

  Cincinnati Children's Hospital Medical Center

  27 shared

• Jennifer Davis

  Northwestern University

  26 shared

• Marjorie Maillet

  Cincinnati Children's Hospital Medical Center

  25 shared

Education

• Ph.D.

  University of Turin

  2007

Similar researchers at Brown University

• Ellen McCreedyh-30
• Kereen Coulombeh-29
• Sofia Lizarragah-25